6LVM
Crystal structure of FGFR3 in complex with pyrimidine derivative
Experimental procedure
Experimental method | SINGLE WAVELENGTH |
Source type | SYNCHROTRON |
Source details | PHOTON FACTORY BEAMLINE AR-NE3A |
Synchrotron site | Photon Factory |
Beamline | AR-NE3A |
Temperature [K] | 90 |
Detector technology | CCD |
Collection date | 2010-12-13 |
Detector | ADSC QUANTUM 270 |
Wavelength(s) | 1 |
Spacegroup name | P 1 21 1 |
Unit cell lengths | 48.143, 61.225, 59.645 |
Unit cell angles | 90.00, 112.98, 90.00 |
Refinement procedure
Resolution | 29.360 - 2.530 |
R-factor | 0.2109 |
Rwork | 0.207 |
R-free | 0.27890 |
Structure solution method | MOLECULAR REPLACEMENT |
Starting model (for MR) | 3b2t |
RMSD bond length | 0.005 |
RMSD bond angle | 1.603 |
Data reduction software | HKL-2000 |
Data scaling software | HKL-2000 |
Phasing software | PHASER |
Refinement software | REFMAC (5.8.0253) |
Data quality characteristics
Overall | Inner shell | Outer shell | |
Low resolution limit [Å] | 50.000 | 50.000 | 2.580 |
High resolution limit [Å] | 2.530 | 6.890 | 2.540 |
Rmerge | 0.073 | 0.055 | 0.370 |
Number of reflections | 10740 | 536 | 506 |
<I/σ(I)> | 13.9 | ||
Completeness [%] | 99.4 | 94 | 96.4 |
Redundancy | 3.6 | 3.2 | 3 |
Crystallization Conditions
crystal ID | method | pH | temperature | details |
1 | VAPOR DIFFUSION, SITTING DROP | 5 | 296 | Citric Acid, PEG 8000 |