6LVM

Crystal structure of FGFR3 in complex with pyrimidine derivative

Summary for 6LVM

Entry DOI	10.2210/pdb6lvm/pdb
Related	6LVK 6LVL
Descriptor	Fibroblast growth factor receptor 3, 2-[[5-[2-(3,5-dimethoxyphenyl)ethyl]-2-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]pyrimidin-4-yl]amino]-N-ethyl-benzenesulfonamide (3 entities in total)
Functional Keywords	protein kinase, signaling protein, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36409.68
Authors	Echizen, Y.,Tateishi, Y.,Amano, Y. (deposition date: 2020-02-04, release date: 2020-04-08, Last modification date: 2023-11-29)
Primary citation	Kuriwaki, I.,Kameda, M.,Hisamichi, H.,Kikuchi, S.,Iikubo, K.,Kawamoto, Y.,Moritomo, H.,Kondoh, Y.,Amano, Y.,Tateishi, Y.,Echizen, Y.,Iwai, Y.,Noda, A.,Tomiyama, H.,Suzuki, T.,Hirano, M. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg.Med.Chem., 28:115453-115453, 2020 Cited by PubMed: 32278710 DOI: 10.1016/j.bmc.2020.115453 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.53 Å)

Structure validation