6LVM
Crystal structure of FGFR3 in complex with pyrimidine derivative
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Fibroblast growth factor receptor 3 | polymer | 313 | 35664.7 | 1 | UniProt (P22607) Pfam (PF07714) In PDB | Homo sapiens (Human) | FGFR-3 |
2 | A | 2-[[5-[2-(3,5-dimethoxyphenyl)ethyl]-2-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]pyrimidin-4-yl]amino]-N-ethyl-benzenesulfonamide | non-polymer | 744.9 | 1 | Chemie (EVR) | |||
3 | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A: 472 - 759 (UniProt: P22607)
PDB | External Database | Details |
---|---|---|
Gly 447 | - | expression tag |
Ser 448 | - | expression tag |
His 449 | - | expression tag |
Met 450 | - | expression tag |
Leu 451 | - | expression tag |
Ala 452 | - | expression tag |
Gly 453 | - | expression tag |
Val 454 | - | expression tag |
Ser 455 | - | expression tag |
Glu 456 | - | expression tag |
Tyr 457 | - | expression tag |
Glu 458 | - | expression tag |
Leu 459 | - | expression tag |
Pro 460 | - | expression tag |
Glu 461 | - | expression tag |
Asp 462 | - | expression tag |
Pro 463 | - | expression tag |
Lys 464 | - | expression tag |
Trp 465 | - | expression tag |
Glu 466 | - | expression tag |
Phe 467 | - | expression tag |
Pro 468 | - | expression tag |
Arg 469 | - | expression tag |
Asp 470 | - | expression tag |
Lys 471 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35664.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 744.9 | |
All* | Total formula weight | 36409.7 |