2OH4
Crystal structure of Vegfr2 with a benzimidazole-urea inhibitor
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | APS BEAMLINE 17-ID |
| Synchrotron site | APS |
| Beamline | 17-ID |
| Temperature [K] | 100 |
| Detector technology | CCD |
| Collection date | 2001-02-01 |
| Detector | MAR CCD 165 mm |
| Wavelength(s) | 1.0 |
| Spacegroup name | P 21 21 21 |
| Unit cell lengths | 38.370, 94.250, 95.754 |
| Unit cell angles | 90.00, 90.00, 90.00 |
Refinement procedure
| Resolution | 47.670 - 2.050 |
| R-factor | 0.189 |
| Rwork | 0.187 |
| R-free | 0.23100 |
| Structure solution method | MOLECULAR REPLACEMENT |
| Starting model (for MR) | 1ywn |
| RMSD bond length | 0.010 |
| RMSD bond angle | 1.163 |
| Data reduction software | DENZO |
| Data scaling software | SCALEPACK |
| Phasing software | AMoRE |
| Refinement software | REFMAC |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 47.670 | 2.120 |
| High resolution limit [Å] | 2.050 | 2.050 |
| Rmerge | 0.064 | 0.179 |
| Number of reflections | 22437 | |
| <I/σ(I)> | 24.6 | 2.029 |
| Completeness [%] | 99.5 | 93.6 |
| Redundancy | 6.7 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, HANGING DROP | 7.2 | 277 | pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 277K |
