2OH4

Crystal structure of Vegfr2 with a benzimidazole-urea inhibitor

Summary for 2OH4

Entry DOI	10.2210/pdb2oh4/pdb
Related	1vr2 1y6a 1y6b 1ywm
Descriptor	Vascular endothelial growth factor receptor 2, SULFATE ION, METHYL (5-{4-[({[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-1H-BENZIMIDAZOL-2-YL)CARBAMATE, ... (4 entities in total)
Functional Keywords	vascular endothelial growth factor receptor 2, tyrosine-protein kinase, angiogenesis, atp-binding, phosphorylation, kinase insert domain receptor, protein-tyrosine kinase receptor flk-1, transferase
Biological source	Homo sapiens (Human) More
Cellular location	Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
Total number of polymer chains	1
Total formula weight	37104.21
Authors	Nolte, R.T.,Wang, L. (deposition date: 2007-01-09, release date: 2007-09-18, Last modification date: 2023-11-15)
Primary citation	Hasegawa, M.,Nishigaki, N.,Washio, Y.,Kano, K.,Harris, P.A.,Sato, H.,Mori, I.,West, R.I.,Shibahara, M.,Toyoda, H.,Wang, L.,Nolte, R.T.,Veal, J.M.,Cheung, M. Discovery of Novel Benzimidazoles as Potent Inhibitors of TIE-2 and VEGFR-2 Tyrosine Kinase Receptors. J.Med.Chem., 50:4453-4470, 2007 Cited by PubMed: 17676829 DOI: 10.1021/jm0611051 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation