2OH4
Crystal structure of Vegfr2 with a benzimidazole-urea inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Vascular endothelial growth factor receptor 2 | polymer | 316 | 36408.7 | 1 | UniProt (P35968) Pfam (PF07714) In PDB | Homo sapiens (Human) | VEGFR-2,Fetal liver kinase 1,FLK-1,Kinase insert domain receptor,KDR,Protein-tyrosine kinase receptor flk-1 |
2 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
3 | A | METHYL (5-{4-[({[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-1H-BENZIMIDAZOL-2-YL)CARBAMATE | non-polymer | 503.4 | 1 | Chemie (GIG) | |||
4 | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
A: 804 - 989 (UniProt: P35968)
A: 990 - 1169 (UniProt: P35968)
PDB | External Database | Details |
---|---|---|
His 803 | - | expression tag |
Asn 833 | Lys 835 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36408.7 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 695.5 | |
All* | Total formula weight | 37104.2 |