10AJ
 
 | | Crystal Structure of Human WRN helicase with compound 1 | | Descriptor: | 1,2-ETHANEDIOL, 4-(4-methyl-4H-1,2,4-triazol-3-yl)-1-[4-(1H-pyrrol-1-yl)benzene-1-sulfonyl]piperidine, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ... | | Authors: | Toms, A.V, Caravella, J.A, Sitnikov, N, Bartels, F, Svensson, R, Jacques O'Hagan, S, Borthwick, J, Campos, S, Yin, Y, Zhao, X, Li, L, Talbot, E, Kong, H, Freund, R.R.A, Browning, B, Genung, N.E, Carreiro, S, Brennan, D, Graves, A.P, Loh, C, Tummino, P, Edmonson, S.E, Li, D. | | Deposit date: | 2026-01-08 | | Release date: | 2026-05-13 | | Last modified: | 2026-06-10 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Design of Cyclic Vinyl Sulfones as WRN Covalent Inhibitors from Noncovalent Binders.
J.Med.Chem., 69, 2026
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10AK
 | | Crystal Structure of Human WRN helicase with compound 4 | | Descriptor: | 1,2-ETHANEDIOL, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, CHLORIDE ION, ... | | Authors: | Toms, A.V, Caravella, J.A, Sitnikov, N, Bartels, F, Svensson, R, Jacques O'Hagan, S, Borthwick, J, Yin, Y, Zhoa, X, Li, L, Liu, R, Talbot, E, Kong, H, Freund, R.R.A, Browning, B, Genung, N, Carreiro, S, Brennan, D, Graves, A.P, Loh, C, Tummino, P, Edmondson, S.D, Li, D. | | Deposit date: | 2026-01-08 | | Release date: | 2026-05-13 | | Last modified: | 2026-06-10 | | Method: | X-RAY DIFFRACTION (1.37 Å) | | Cite: | Design of Cyclic Vinyl Sulfones as WRN Covalent Inhibitors from Noncovalent Binders.
J.Med.Chem., 69, 2026
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10AP
 | | Crystal Structure of Human WRN helicase with compound 26 | | Descriptor: | (2R)-N-[(3R)-1,1-dioxo-1lambda~6~-thiolan-3-yl]-N-{[2-(2-hydroxypropan-2-yl)pyridin-4-yl]methyl}-2-methoxy-2-[(1M)-3,3',4'-trifluoro[1,1'-biphenyl]-4-yl]acetamide, 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Toms, A.V, Caravella, J.A, Sitnikov, N, Bartels, F, Svensson, R, Jacques O'Hagan, S, Borthwick, J, Campos, S, Yin, Y, Zhao, X, Li, L, Talbot, E, Kong, H, Freund, R.R.A, Browning, B, Genung, N.E, Carreiro, S, Brennan, D, Graves, A.P, Loh, C, Tummino, P, Edmonson, S.D, Li, D. | | Deposit date: | 2026-01-08 | | Release date: | 2026-05-13 | | Last modified: | 2026-06-10 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | Design of Cyclic Vinyl Sulfones as WRN Covalent Inhibitors from Noncovalent Binders.
J.Med.Chem., 69, 2026
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10EN
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10EV
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10EX
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10EY
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10EZ
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10FD
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10FE
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10FF
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10FL
 | | SK5G-Germline | | Descriptor: | Glutamate receptor ionotropic, NMDA 1, NMDA 2B, ... | | Authors: | Kleeman, S.O, Furukawa, H.F. | | Deposit date: | 2026-01-16 | | Release date: | 2026-03-25 | | Last modified: | 2026-06-10 | | Method: | ELECTRON MICROSCOPY (3.81 Å) | | Cite: | Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity.
Nature, 653, 2026
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10FN
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10FO
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10YN
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11AD
 | | Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B | | Descriptor: | (7R)-8-cyclopentyl-2-(3,5-dichloro-4-hydroxyanilino)-5-methyl-7-[(pyridin-2-yl)methyl]-7,8-dihydropteridin-6(5H)-one, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION | | Authors: | He, Z, Ha, Y. | | Deposit date: | 2026-02-13 | | Release date: | 2026-04-29 | | Last modified: | 2026-06-10 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B.
Acta Crystallogr D Struct Biol, 82, 2026
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11UE
 | | Structure of PDGFRb Kinase Domain Bound to JNJ-PDGFRBi-1 | | Descriptor: | N-[2-(2,2-dimethylpyrrolidin-1-yl)ethyl]-6-methyl-5-({1-methyl-6-[(1-methyl-1H-pyrazol-4-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}amino)pyridine-3-carboxamide, Platelet-derived growth factor receptor beta | | Authors: | Shaffer, P.L, Duda, D. | | Deposit date: | 2026-03-13 | | Release date: | 2026-05-20 | | Last modified: | 2026-06-10 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | Identification of an Inhaled Pulmonary Selective PDGFR Inhibitor with Sustained Target Engagement.
J Aerosol Med Pulm Drug Deliv, 2026
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11YE
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11ZC
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21CI
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21FT
 | | GABA aminotransferase from Arabidopsis thaliana | | Descriptor: | Gamma-aminobutyrate transaminase POP2, mitochondrial | | Authors: | Okoda, N, Okuda, S, Tsutsumi, K, Sano, K, Kobata, K, Nagata, K. | | Deposit date: | 2025-12-12 | | Release date: | 2026-06-03 | | Last modified: | 2026-06-10 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of the plant GABA aminotransferase AtGABA-T from Arabidopsis thaliana.
Acta Crystallogr.,Sect.F, 82, 2026
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23IV
 | | Cannabinoid Receptor 1-Gi Complex | | Descriptor: | Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Liao, Y, Zhang, Y. | | Deposit date: | 2026-02-07 | | Release date: | 2026-05-20 | | Last modified: | 2026-06-10 | | Method: | ELECTRON MICROSCOPY (2.42 Å) | | Cite: | Rational design of G i -biased CB1 agonist with reduced side effects.
Cell, 189, 2026
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23IW
 | | Cannabinoid Receptor 1-Gi Complex | | Descriptor: | Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Liao, Y, Zhang, Y. | | Deposit date: | 2026-02-07 | | Release date: | 2026-05-20 | | Last modified: | 2026-06-10 | | Method: | ELECTRON MICROSCOPY (2.42 Å) | | Cite: | Rational design of G i -biased CB1 agonist with reduced side effects.
Cell, 189, 2026
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23VK
 | | Crystal structure of full-length of APS kinase from Entamoeba histolytica | | Descriptor: | SULFATE ION, adenylyl-sulfate kinase | | Authors: | Hatanaka, R, Yuasa, H, Inoguchi, A, Matsui, H, Osumi, Y, Mi-ichi, F, Kishikawa, J, Shiba, T. | | Deposit date: | 2026-02-20 | | Release date: | 2026-06-03 | | Last modified: | 2026-06-10 | | Method: | X-RAY DIFFRACTION (2.595 Å) | | Cite: | Structural insights into interdomain interactions in Entamoeba histolytica APS kinase.
J Struct Biol X, 13, 2026
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23VL
 | | Crystal structure of AS-like domain of APS kinase from Entamoeba histolytica | | Descriptor: | adenylyl-sulfate kinase | | Authors: | Hatanaka, R, Yuasa, H, Inoguchi, A, Matsui, H, Osumi, Y, Mi-ichi, F, Kishikawa, J, Shiba, T. | | Deposit date: | 2026-02-20 | | Release date: | 2026-06-03 | | Last modified: | 2026-06-10 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural insights into interdomain interactions in Entamoeba histolytica APS kinase.
J Struct Biol X, 13, 2026
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