5TQW
 
 | | CryoEM reconstruction of human IKK1, open conformation 1 | | 分子名称: | Inhibitor of nuclear factor kappa-B kinase subunit alpha | | 著者 | Lyumkis, D, Ghosh, G, Polley, S, Biswas, T, Huang, D, Passos, D.O. | | 登録日 | 2016-10-24 | | 公開日 | 2016-11-09 | | 最終更新日 | 2026-02-25 | | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | | 主引用文献 | Structural Basis for the Activation of IKK1/ alpha.
Cell Rep, 17, 2016
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5TQX
 | | CryoEM reconstruction of human IKK1, intermediate conformation 2 | | 分子名称: | Inhibitor of nuclear factor kappa-B kinase subunit alpha | | 著者 | Lyumkis, D, Ghosh, G, Polley, S, Biswas, T, Huang, D, Passos, D.O. | | 登録日 | 2016-10-24 | | 公開日 | 2016-11-09 | | 最終更新日 | 2026-02-25 | | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | | 主引用文献 | Structural Basis for the Activation of IKK1/ alpha.
Cell Rep, 17, 2016
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5TQY
 | | CryoEM reconstruction of human IKK1, closed conformation 3 | | 分子名称: | Inhibitor of nuclear factor kappa-B kinase subunit alpha | | 著者 | Lyumkis, D, Ghosh, G, Polley, S, Biswas, T, Huang, D, Passos, D.O. | | 登録日 | 2016-10-24 | | 公開日 | 2016-11-09 | | 最終更新日 | 2026-02-25 | | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | | 主引用文献 | Structural Basis for the Activation of IKK1/ alpha.
Cell Rep, 17, 2016
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5TVL
 | | Crystal structure of foldase protein PrsA from Streptococcus pneumoniae str. Canada MDR_19A | | 分子名称: | CHLORIDE ION, Foldase protein PrsA, GLYCEROL, ... | | 著者 | Borek, D, Yim, V, Kudritska, M, Wawrzak, Z, Stogios, P.J, Otwinowski, Z, Savchenko, A, Anderson, W, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2016-11-09 | | 公開日 | 2016-11-23 | | 最終更新日 | 2026-02-25 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Structural analysis of extracellular ATP-independent chaperones of streptococcal species and protein substrate interactions.
Msphere, 10, 2025
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5VGC
 | | Crystal structure of the NleG5-1 effector (C200A) from Escherichia coli O157:H7 str. Sakai | | 分子名称: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | | 著者 | Borek, D, Valleau, D, Skarina, T, Jobin, M.C, Wawrzak, Z, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2017-04-10 | | 公開日 | 2018-04-18 | | 最終更新日 | 2026-02-25 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Functional diversification of the NleG effector family in enterohemorrhagic Escherichia coli.
Proc.Natl.Acad.Sci.USA, 115, 2018
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6K4I
 | | The partially disordered conformation of ubiquitin (Q41N variant) | | 分子名称: | ubiquitin | | 著者 | Wakamoto, T, Ikeya, T, Kitazawa, S, Baxter, N.J, Williamson, M.P, Kitahara, R. | | 登録日 | 2019-05-24 | | 公開日 | 2019-10-30 | | 最終更新日 | 2026-02-25 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Paramagnetic relaxation enhancement-assisted structural characterization of a partially disordered conformation of ubiquitin.
Protein Sci., 28, 2019
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6OKZ
 | | Structure of VcINDY bound to Fumarate | | 分子名称: | FUMARIC ACID, SODIUM ION, Transporter, ... | | 著者 | Sauer, D.B, Marden, J, Wang, D.N. | | 登録日 | 2019-04-15 | | 公開日 | 2020-10-28 | | 最終更新日 | 2026-02-25 | | 実験手法 | X-RAY DIFFRACTION (3.292 Å) | | 主引用文献 | Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter.
Proc.Natl.Acad.Sci.USA, 123, 2026
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6OL0
 | | Structure of VcINDY bound to Malate | | 分子名称: | (2S)-2-hydroxybutanedioic acid, SODIUM ION, Transporter, ... | | 著者 | Sauer, D.B, Marden, J.J, Wang, D.N. | | 登録日 | 2019-04-15 | | 公開日 | 2020-10-28 | | 最終更新日 | 2026-02-25 | | 実験手法 | X-RAY DIFFRACTION (3.502 Å) | | 主引用文献 | Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter.
Proc.Natl.Acad.Sci.USA, 123, 2026
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6OL1
 | | Structure of VcINDY in complex with Succinate | | 分子名称: | SODIUM ION, SUCCINIC ACID, Transporter, ... | | 著者 | Sauer, D.B, Marden, J.J, Wang, D.N. | | 登録日 | 2019-04-15 | | 公開日 | 2020-10-28 | | 最終更新日 | 2026-02-25 | | 実験手法 | X-RAY DIFFRACTION (3.088 Å) | | 主引用文献 | Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter.
Proc.Natl.Acad.Sci.USA, 123, 2026
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6SG2
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6UQF
 | | Human HCN1 channel in a hyperpolarized conformation | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, MERCURY (II) ION, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | 著者 | Lee, C.-H, MacKinnon, R. | | 登録日 | 2019-10-19 | | 公開日 | 2019-12-11 | | 最終更新日 | 2026-02-25 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Voltage Sensor Movements during Hyperpolarization in the HCN Channel.
Cell, 179, 2019
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7QVD
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7UUJ
 | | Crystal structure of aminoglycoside resistance enzyme ApmA, complex with gentamicin | | 分子名称: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, ... | | 著者 | Stogios, P.J, Evdokimova, E, Osipiuk, J, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID) | | 登録日 | 2022-04-28 | | 公開日 | 2023-04-19 | | 最終更新日 | 2026-02-25 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
Nat.Chem.Biol., 20, 2024
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7UUK
 | | Crystal structure of aminoglycoside resistance enzyme ApmA, complex with tobramycin | | 分子名称: | Aminocyclitol acetyltransferase ApmA, CHLORIDE ION, TOBRAMYCIN | | 著者 | Stogios, P.J, Evdokimova, E, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID) | | 登録日 | 2022-04-28 | | 公開日 | 2023-04-19 | | 最終更新日 | 2026-02-25 | | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | | 主引用文献 | Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
Nat.Chem.Biol., 20, 2024
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7UUL
 | | Crystal structure of aminoglycoside resistance enzyme ApmA, complex with kanamycin B and coenzyme A | | 分子名称: | (1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL 2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE, 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, ... | | 著者 | Stogios, P.J, Evdokimova, E, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID) | | 登録日 | 2022-04-28 | | 公開日 | 2022-11-02 | | 最終更新日 | 2026-02-25 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
Nat.Chem.Biol., 20, 2024
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7UUM
 | | Crystal structure of aminoglycoside resistance enzyme ApmA, complex with paromomycin and coenzyme A | | 分子名称: | Aminocyclitol acetyltransferase ApmA, COENZYME A, GLYCEROL, ... | | 著者 | Stogios, P.J, Evdokimova, E, Osipiuk, J, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID) | | 登録日 | 2022-04-28 | | 公開日 | 2022-11-02 | | 最終更新日 | 2026-02-25 | | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | | 主引用文献 | Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
Nat.Chem.Biol., 20, 2024
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7UUN
 | | Crystal structure of aminoglycoside resistance enzyme ApmA, complex with neomycin | | 分子名称: | 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, NEOMYCIN | | 著者 | Stogios, P.J, Evdokimova, E, Di Leo, R, Osipiuk, J, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID) | | 登録日 | 2022-04-28 | | 公開日 | 2022-11-02 | | 最終更新日 | 2026-02-25 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
Nat.Chem.Biol., 20, 2024
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7UUO
 | | Crystal structure of aminoglycoside resistance enzyme ApmA H135A mutant, complex with tobramycin and coenzyme A | | 分子名称: | 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, COENZYME A, ... | | 著者 | Stogios, P.J, Evdokimova, E, Michalska, K, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID) | | 登録日 | 2022-04-28 | | 公開日 | 2022-11-02 | | 最終更新日 | 2026-02-25 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
Nat.Chem.Biol., 20, 2024
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8BA7
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8BA8
 | | CryoEM structure of GroEL-ADP.BeF3-Rubisco. | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chaperonin GroEL, ... | | 著者 | Gardner, S, Saibil, H.R. | | 登録日 | 2022-10-11 | | 公開日 | 2023-12-27 | | 最終更新日 | 2026-02-25 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis of substrate progression through the bacterial chaperonin cycle.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8BA9
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8BAA
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8BJ7
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8BJ8
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8EZR
 | | Crystal structure of the HipS(Lp)-HipT(Lp) complex from Legionella pneumophila, native protein | | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, HipS(Lp), ... | | 著者 | Stogios, P.J, Skarina, T, Michalska, K, Di Leo, R, Lin, J, Ensminger, A, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2022-11-01 | | 公開日 | 2023-09-27 | | 最終更新日 | 2026-02-25 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Functional diversification despite structural congruence in the HipBST toxin-antitoxin system of Legionella pneumophila.
Mbio, 14, 2023
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