10AJ
 
 | | Crystal Structure of Human WRN helicase with compound 1 | | 分子名称: | 1,2-ETHANEDIOL, 4-(4-methyl-4H-1,2,4-triazol-3-yl)-1-[4-(1H-pyrrol-1-yl)benzene-1-sulfonyl]piperidine, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ... | | 著者 | Toms, A.V, Caravella, J.A, Sitnikov, N, Bartels, F, Svensson, R, Jacques O'Hagan, S, Borthwick, J, Campos, S, Yin, Y, Zhao, X, Li, L, Talbot, E, Kong, H, Freund, R.R.A, Browning, B, Genung, N.E, Carreiro, S, Brennan, D, Graves, A.P, Loh, C, Tummino, P, Edmonson, S.E, Li, D. | | 登録日 | 2026-01-08 | | 公開日 | 2026-05-13 | | 最終更新日 | 2026-06-10 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Design of Cyclic Vinyl Sulfones as WRN Covalent Inhibitors from Noncovalent Binders.
J.Med.Chem., 69, 2026
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10AK
 | | Crystal Structure of Human WRN helicase with compound 4 | | 分子名称: | 1,2-ETHANEDIOL, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, CHLORIDE ION, ... | | 著者 | Toms, A.V, Caravella, J.A, Sitnikov, N, Bartels, F, Svensson, R, Jacques O'Hagan, S, Borthwick, J, Yin, Y, Zhoa, X, Li, L, Liu, R, Talbot, E, Kong, H, Freund, R.R.A, Browning, B, Genung, N, Carreiro, S, Brennan, D, Graves, A.P, Loh, C, Tummino, P, Edmondson, S.D, Li, D. | | 登録日 | 2026-01-08 | | 公開日 | 2026-05-13 | | 最終更新日 | 2026-06-10 | | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | | 主引用文献 | Design of Cyclic Vinyl Sulfones as WRN Covalent Inhibitors from Noncovalent Binders.
J.Med.Chem., 69, 2026
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10AP
 | | Crystal Structure of Human WRN helicase with compound 26 | | 分子名称: | (2R)-N-[(3R)-1,1-dioxo-1lambda~6~-thiolan-3-yl]-N-{[2-(2-hydroxypropan-2-yl)pyridin-4-yl]methyl}-2-methoxy-2-[(1M)-3,3',4'-trifluoro[1,1'-biphenyl]-4-yl]acetamide, 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Toms, A.V, Caravella, J.A, Sitnikov, N, Bartels, F, Svensson, R, Jacques O'Hagan, S, Borthwick, J, Campos, S, Yin, Y, Zhao, X, Li, L, Talbot, E, Kong, H, Freund, R.R.A, Browning, B, Genung, N.E, Carreiro, S, Brennan, D, Graves, A.P, Loh, C, Tummino, P, Edmonson, S.D, Li, D. | | 登録日 | 2026-01-08 | | 公開日 | 2026-05-13 | | 最終更新日 | 2026-06-10 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Design of Cyclic Vinyl Sulfones as WRN Covalent Inhibitors from Noncovalent Binders.
J.Med.Chem., 69, 2026
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10EN
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10EV
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10EX
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10EY
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10EZ
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10FD
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10FE
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10FF
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10FL
 | | SK5G-Germline | | 分子名称: | Glutamate receptor ionotropic, NMDA 1, NMDA 2B, ... | | 著者 | Kleeman, S.O, Furukawa, H.F. | | 登録日 | 2026-01-16 | | 公開日 | 2026-03-25 | | 最終更新日 | 2026-06-10 | | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | | 主引用文献 | Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity.
Nature, 653, 2026
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10FN
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10FO
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10YN
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11AD
 | | Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B | | 分子名称: | (7R)-8-cyclopentyl-2-(3,5-dichloro-4-hydroxyanilino)-5-methyl-7-[(pyridin-2-yl)methyl]-7,8-dihydropteridin-6(5H)-one, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION | | 著者 | He, Z, Ha, Y. | | 登録日 | 2026-02-13 | | 公開日 | 2026-04-29 | | 最終更新日 | 2026-06-10 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B.
Acta Crystallogr D Struct Biol, 82, 2026
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11UE
 | | Structure of PDGFRb Kinase Domain Bound to JNJ-PDGFRBi-1 | | 分子名称: | N-[2-(2,2-dimethylpyrrolidin-1-yl)ethyl]-6-methyl-5-({1-methyl-6-[(1-methyl-1H-pyrazol-4-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}amino)pyridine-3-carboxamide, Platelet-derived growth factor receptor beta | | 著者 | Shaffer, P.L, Duda, D. | | 登録日 | 2026-03-13 | | 公開日 | 2026-05-20 | | 最終更新日 | 2026-06-10 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Identification of an Inhaled Pulmonary Selective PDGFR Inhibitor with Sustained Target Engagement.
J Aerosol Med Pulm Drug Deliv, 2026
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11YE
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11ZC
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21CI
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21FT
 | | GABA aminotransferase from Arabidopsis thaliana | | 分子名称: | Gamma-aminobutyrate transaminase POP2, mitochondrial | | 著者 | Okoda, N, Okuda, S, Tsutsumi, K, Sano, K, Kobata, K, Nagata, K. | | 登録日 | 2025-12-12 | | 公開日 | 2026-06-03 | | 最終更新日 | 2026-06-10 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the plant GABA aminotransferase AtGABA-T from Arabidopsis thaliana.
Acta Crystallogr.,Sect.F, 82, 2026
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23IV
 | | Cannabinoid Receptor 1-Gi Complex | | 分子名称: | Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liao, Y, Zhang, Y. | | 登録日 | 2026-02-07 | | 公開日 | 2026-05-20 | | 最終更新日 | 2026-06-10 | | 実験手法 | ELECTRON MICROSCOPY (2.42 Å) | | 主引用文献 | Rational design of G i -biased CB1 agonist with reduced side effects.
Cell, 189, 2026
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23IW
 | | Cannabinoid Receptor 1-Gi Complex | | 分子名称: | Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liao, Y, Zhang, Y. | | 登録日 | 2026-02-07 | | 公開日 | 2026-05-20 | | 最終更新日 | 2026-06-10 | | 実験手法 | ELECTRON MICROSCOPY (2.42 Å) | | 主引用文献 | Rational design of G i -biased CB1 agonist with reduced side effects.
Cell, 189, 2026
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23VK
 | | Crystal structure of full-length of APS kinase from Entamoeba histolytica | | 分子名称: | SULFATE ION, adenylyl-sulfate kinase | | 著者 | Hatanaka, R, Yuasa, H, Inoguchi, A, Matsui, H, Osumi, Y, Mi-ichi, F, Kishikawa, J, Shiba, T. | | 登録日 | 2026-02-20 | | 公開日 | 2026-06-03 | | 最終更新日 | 2026-06-10 | | 実験手法 | X-RAY DIFFRACTION (2.595 Å) | | 主引用文献 | Structural insights into interdomain interactions in Entamoeba histolytica APS kinase.
J Struct Biol X, 13, 2026
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23VL
 | | Crystal structure of AS-like domain of APS kinase from Entamoeba histolytica | | 分子名称: | adenylyl-sulfate kinase | | 著者 | Hatanaka, R, Yuasa, H, Inoguchi, A, Matsui, H, Osumi, Y, Mi-ichi, F, Kishikawa, J, Shiba, T. | | 登録日 | 2026-02-20 | | 公開日 | 2026-06-03 | | 最終更新日 | 2026-06-10 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural insights into interdomain interactions in Entamoeba histolytica APS kinase.
J Struct Biol X, 13, 2026
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