PDB形式変換不可の PDB エントリー

9CAQ	Cryo-EM structure of a human MCM2-7 double hexamer formed from independently loaded MCM2-7 single hexamers 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (44-MER), ... 著者 Yang, R, Hunker, O, Bleichert, F. 登録日 2024-06-17 公開日 2024-10-02 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Multiple pathways for licensing human replication origins To Be Published
9CBF	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with m-Aminomethyl Phenylthioketone 分子名称: 1,2-ETHANEDIOL, 1-[3-(aminomethyl)phenyl]-2-sulfanylethan-1-one, PHOSPHATE ION, ... 著者 Goulart Stollmaier, J, Christianson, D.W. 登録日 2024-06-19 公開日 2024-09-11 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Design, Synthesis and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10 To Be Published
9CBG	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with m-Aminoethyl Phenylthioketone 分子名称: 1,2-ETHANEDIOL, 1-[3-(2-aminoethyl)phenyl]-2-sulfanylethan-1-one, PHOSPHATE ION, ... 著者 Goulart Stollmaier, J, Christianson, D.W. 登録日 2024-06-19 公開日 2024-09-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10 To be Published
9CBH	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with p-Aminomethyl Phenylthioketone 分子名称: 1-[4-(aminomethyl)phenyl]-2-sulfanylethan-1-one, PHOSPHATE ION, POTASSIUM ION, ... 著者 Goulart Stollmaier, J, Christianson, D.W. 登録日 2024-06-19 公開日 2024-09-11 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10 To be Published
9CBI	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with p-Aminoethyl Phenylthioketone 分子名称: 1,2-ETHANEDIOL, 1-[4-(2-aminoethyl)phenyl]-2-sulfanylethan-1-one, PHOSPHATE ION, ... 著者 Goulart Stollmaier, J, Christianson, D.W. 登録日 2024-06-19 公開日 2024-09-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10 To be Published
9CBJ	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with p-Aminopropyl Phenylthioketone 分子名称: 1,2-ETHANEDIOL, 1-[4-(3-aminopropyl)phenyl]-2-sulfanylethan-1-one, PHOSPHATE ION, ... 著者 Goulart Stollmaier, J, Christianson, D.W. 登録日 2024-06-19 公開日 2024-09-11 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10 To be Published
9CBK	Crystal Structure of Danio rerio Histone Deacetylase 6 in Complex with p-Aminomethyl Phenylthioketone 分子名称: 1,2-ETHANEDIOL, 1-[4-(aminomethyl)phenyl]-2-sulfanylethan-1-one, Hdac6 protein, ... 著者 Goulart Stollmaier, J, Watson, P.R, Christianson, D.W. 登録日 2024-06-19 公開日 2024-09-11 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10 To be Published
9CC9	Dodecameric state of the NRC4 resistosome 分子名称: ADENOSINE-5'-TRIPHOSPHATE, NLR-required for cell death 4 著者 Liu, F, Yang, Z, Nogales, E, Staskawicz, B.J. 登録日 2024-06-21 公開日 2024-09-11 最終更新日 2024-09-18 実験手法 ELECTRON MICROSCOPY (3.54 Å) 主引用文献 Activation of the helper NRC4 immune receptor forms a hexameric resistosome. Cell, 187, 2024
9CD5	FGFR1 Kinase Domain Soak with Inhibitor TYRA-300 分子名称: (3P)-5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-3-{6-[6-(methanesulfonyl)-2,6-diazaspiro[3.3]heptan-2-yl]pyridin-3-yl}-1H-indazole, 1,2-ETHANEDIOL, Fibroblast growth factor receptor 1, ... 著者 Hoffman, I.H, Nelson, K.J, Rideout, M.C, Frye, C, Bensen, D.C, Hudkins, R.L. 登録日 2024-06-24 公開日 2024-09-25 最終更新日 2024-10-02 実験手法 X-RAY DIFFRACTION (2.939 Å) 主引用文献 Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia. J.Med.Chem., 67, 2024
9CD7	FGFR3 Kinase Domain with Inhibitor TYRA-300 分子名称: (3P)-5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-3-{6-[6-(methanesulfonyl)-2,6-diazaspiro[3.3]heptan-2-yl]pyridin-3-yl}-1H-indazole, Fibroblast growth factor receptor 3, GLYCEROL, ... 著者 Hoffman, I.H, Nelson, K.J, Rideout, M.C, Nix, J.C, Frye, C, Bensen, D.C, Hudkins, R.L. 登録日 2024-06-24 公開日 2024-09-25 最終更新日 2024-10-02 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia. J.Med.Chem., 67, 2024
9CE4	Structure of CHK1 10-pt. mutant complex with LRRK2 indazole inhibitor compound 6 分子名称: (1S,4r)-4-[(1P)-5-chloro-1-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-6-yl]-1-(oxetan-3-yl)piperidin-1-ium, 1,2-ETHANEDIOL, Serine/threonine-protein kinase Chk1 著者 Palte, R.L, Zebisch, M, Henry, C, Barker, J.J. 登録日 2024-06-26 公開日 2024-09-18 最終更新日 2024-10-02 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors. J.Med.Chem., 67, 2024
9CG5	70S initiation complex (tRNA-fMet M1 + UUG start codon) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Mattingly, J.M, Nguyen, H.A, Dunham, C.M. 登録日 2024-06-28 公開日 2024-09-18 実験手法 ELECTRON MICROSCOPY (2.59 Å) 主引用文献 Structural analysis of noncanonical translation initiation complexes. J.Biol.Chem., 2024
9CG6	70S initiation complex (tRNA-fMet M1 + GUG start codon) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Mattingly, J.M, Nguyen, H.A, Dunham, C.M. 登録日 2024-06-28 公開日 2024-09-18 実験手法 ELECTRON MICROSCOPY (2.61 Å) 主引用文献 Structural analysis of noncanonical translation initiation complexes. J.Biol.Chem., 2024
9CG7	70S initiation complex (tRNA-fMet M1 + AUG start codon) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Mattingly, J.M, Nguyen, H.A, Dunham, C.M. 登録日 2024-06-28 公開日 2024-09-18 実験手法 ELECTRON MICROSCOPY (2.75 Å) 主引用文献 Structural analysis of noncanonical translation initiation complexes. J.Biol.Chem., 2024
9CGL	Pikromycin Thioesterase Doubly Protected DAP 分子名称: 2-{[(1R)-1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethyl]sulfanyl}ethyl formate, Narbonolide/10-deoxymethynolide synthase PikA4, module 6 著者 McCullough, T.M, Smith, J.L. 登録日 2024-06-29 公開日 2024-09-18 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation Acs Catalysis, 14, 2024
9CGM	The Structure of Spiroplasma Virus 4 分子名称: Capsid protein VP1, DNA binding protein ORF8 著者 Mietzsch, M, McKenna, R. 登録日 2024-06-30 公開日 2024-07-17 最終更新日 2024-08-07 実験手法 ELECTRON MICROSCOPY (2.52 Å) 主引用文献 The Structure of Spiroplasma Virus 4 : Exploring the Capsid Diversity of the Microviridae. Viruses, 16, 2024
9CGN	Pikromycin Thioesterase with heptaketide adduct 分子名称: (2S,4R,5S,6S,8R,12R,13R)-5,13-dihydroxy-2,4,6,8,12-pentamethyl-3,9-dioxopentadecanal, Narbonolide/10-deoxymethynolide synthase PikA4, module 6 著者 Smith, J.L, Choudhary, V. 登録日 2024-06-30 公開日 2024-09-18 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation Acs Catalysis, 14, 2024
9CIH	Crystal structure of human polymerase eta with incoming dCMPnPP nucleotide across O4-methyl threofuranosyl thymidine in DNA template at extension stage 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), DNA (5'-D(*CP*AP*TP*GP*(A1A0L)P*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Tomar, R, Stone, M.P, Egli, M. 登録日 2024-07-03 公開日 2024-09-18 最終更新日 2024-09-25 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta. Biochemistry, 2024
9CIQ	Crystal structure of human polymerase eta with incoming threofuranosyl thymine nucleoside triphosphate opposite template dA 分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... 著者 Patra, A, Tomar, R, Stone, M.P, Egli, M. 登録日 2024-07-04 公開日 2024-09-18 最終更新日 2024-09-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta. Biochemistry, 2024
9CIW	Penguinpox cGAMP PDE H72A mutant in complex with 2'3'-cGAMP 分子名称: Penguinpox cGAMP PDE, [(2~{R},3~{R},4~{R},5~{S})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl [(2~{R},3~{R},4~{S},5~{R})-2-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-5-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl] hydrogen phosphate 著者 Hobbs, S.J, Nomburg, J, Doudna, J.A, Kranzusch, P.J. 登録日 2024-07-05 公開日 2024-09-04 最終更新日 2024-09-11 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Animal and bacterial viruses share conserved mechanisms of immune evasion. Cell, 2024
9CJ9	Crystal structure of human polymerase eta with incoming dAMPnPP nucleotide opposite O4-methyl threofuranosyl thymidine in DNA template at insertion stage 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(TFT)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Tomar, R, Stone, M.P, Egli, M. 登録日 2024-07-05 公開日 2024-09-18 最終更新日 2024-09-25 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta. Biochemistry, 2024
9CL9	WT 12C IM fraction, B-b3 with RluB bound 分子名称: 23S rRNA, Large ribosomal subunit protein bL20, Large ribosomal subunit protein bL21, ... 著者 Lee, J, Sheng, K, Williamson, J.R. 登録日 2024-07-10 公開日 2024-07-24 実験手法 ELECTRON MICROSCOPY (5.04 Å) 主引用文献 50S ribosome assembly intermediates at low temperature reveal bound RluB To Be Published
9CMZ	Crystal Structure of Cdk-related protein kinase 6 (PK6) from Plasmodium falciparum in complex with inhibitor KG2-051 分子名称: (4-{[5-chloro-4-(5-chlorothiophen-2-yl)pyrimidin-2-yl]amino}phenyl)[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone, CHLORIDE ION, Protein kinase 6, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2024-07-15 公開日 2024-07-24 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal Structure of Cdk-related protein kinase 6 (PK6) from Plasmodium falciparum in complex with inhibitor KG2-051 To be published
9CP9	Crystal structure of DHPS-3-dehydrogenase, HpsN H319A variant from Cupriavidus pinatubonensis in complex with substrate (R-DHPS) and NADH 分子名称: (2R)-2,3-dihydroxypropane-1-sulfonic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, SULFATE ION, ... 著者 Lee, M. 登録日 2024-07-18 公開日 2024-09-25 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.013 Å) 主引用文献 Structural and kinetic insights into the stereospecific oxidation of R -2,3-dihydroxypropanesulfonate by DHPS-3-dehydrogenase from Cupriavidus pinatubonensis. Chem Sci, 15, 2024
9CPG	Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1 分子名称: 4-carbamimidamidophenyl 4-carbamimidamidobenzoate, RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') 著者 Chen, J.L, Taghavi, A, Disney, M.D, Fountain, M.A, Childs-Disney, J.L. 登録日 2024-07-18 公開日 2024-08-07 実験手法 SOLUTION NMR 主引用文献 Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1. Bioorg.Med.Chem.Lett., 2024

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