9C8J
 
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9CAI
 | | High-resolution C. elegans 80S ribosome structure - class 2 | | 分子名称: | 18S rRNA, 28S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | | 著者 | Sehgal, E, Serrao, V.H.B, Arribere, J. | | 登録日 | 2024-06-17 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | | 主引用文献 | High-Resolution Reconstruction of a C. elegans Ribosome Sheds Light on Evolutionary Dynamics and Tissue Specificity.
Rna, 2024
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9CBF
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9CBG
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9CBH
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9CBI
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9CBJ
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9CBK
 | | Crystal Structure of Danio rerio Histone Deacetylase 6 in Complex with p-Aminomethyl Phenylthioketone | | 分子名称: | 1,2-ETHANEDIOL, 1-[4-(aminomethyl)phenyl]-2-sulfanylethan-1-one, Hdac6 protein, ... | | 著者 | Goulart Stollmaier, J, Watson, P.R, Christianson, D.W. | | 登録日 | 2024-06-19 | | 公開日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10
To be Published
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9CC9
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9CGM
 | | The Structure of Spiroplasma Virus 4 | | 分子名称: | Capsid protein VP1, DNA binding protein ORF8 | | 著者 | Mietzsch, M, McKenna, R. | | 登録日 | 2024-06-30 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | | 主引用文献 | The Structure of Spiroplasma Virus 4 : Exploring the Capsid Diversity of the Microviridae.
Viruses, 16, 2024
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9CIW
 | | Penguinpox cGAMP PDE H72A mutant in complex with 2'3'-cGAMP | | 分子名称: | Penguinpox cGAMP PDE, [(2~{R},3~{R},4~{R},5~{S})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl [(2~{R},3~{R},4~{S},5~{R})-2-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-5-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl] hydrogen phosphate | | 著者 | Hobbs, S.J, Nomburg, J, Doudna, J.A, Kranzusch, P.J. | | 登録日 | 2024-07-05 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Animal and bacterial viruses share conserved mechanisms of immune evasion.
Cell, 2024
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9CL9
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9CMZ
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9CPG
 | | Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1 | | 分子名称: | 4-carbamimidamidophenyl 4-carbamimidamidobenzoate, RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') | | 著者 | Chen, J.L, Taghavi, A, Disney, M.D, Fountain, M.A, Childs-Disney, J.L. | | 登録日 | 2024-07-18 | | 公開日 | 2024-08-07 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1.
Bioorg.Med.Chem.Lett., 2024
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9CPI
 | | Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1 | | 分子名称: | 4-[1-(2-aminoethyl)-4,5-dihydro-1H-imidazol-2-yl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]benzamide, RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') | | 著者 | Chen, J.L, Taghavi, A, Disney, M.D, Fountain, M.A, Childs-Disney, J.L. | | 登録日 | 2024-07-18 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-08-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structures of small molecules bound to a model of a CUG RNA repeat expansion.
Bioorg.Med.Chem.Lett., 111, 2024
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9CSG
 | | Human Serum Albumin Bound to Cerastecin Compound 5e | | 分子名称: | 2-(4-butylbenzene-1-sulfonamido)-5-(4-{3-carboxy-4-[4-(2-methoxyethyl)benzene-1-sulfonamido]anilino}-4-oxobutanamido)benzoic acid, Albumin, MYRISTIC ACID | | 著者 | Hruza, A, Klein, D.J, Ishchenko, A. | | 登録日 | 2024-07-23 | | 公開日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.914 Å) | | 主引用文献 | Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii : From Screening Impurity to In Vivo Efficacy.
J.Med.Chem., 2024
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9CSI
 | | A. baumannii MsbA Bound to Cerastecin Compound 5 | | 分子名称: | 3,3'-[(1,4-dioxobutane-1,4-diyl)bis(azanediyl)]bis[(4-butylbenzene-1-sulfonamido)benzoic acid], Lipid A export ATP-binding/permease protein MsbA, MAGNESIUM ION, ... | | 著者 | Klein, D.J, Ishchenko, A, Soisson, S, Cheng, R, Hennig, M. | | 登録日 | 2024-07-23 | | 公開日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii : From Screening Impurity to In Vivo Efficacy.
J.Med.Chem., 2024
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9CTH
 | | Preliminary map of the Prothrombin-prothrombinase complex on nano discs | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated Factor V (FVa) heavy chain, Activated Factor V (FVa) light chain, ... | | 著者 | Stojanovski, B.M, Mohammed, B.M, Di Cera, E. | | 登録日 | 2024-07-25 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (6.47 Å) | | 主引用文献 | The Prothrombin-Prothrombinase Interaction.
Subcell Biochem, 104, 2024
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9CUO
 | | Crystal structure of CRBN with compound 3 | | 分子名称: | (3S)-3-(3-methyl-2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)piperidine-2,6-dione, 1,2-ETHANEDIOL, Protein cereblon, ... | | 著者 | Zheng, X, Ji, N, Campbell, V, Slavin, A, Zhu, X, Chen, D, Rong, H, Enerson, B, Mayo, M, Sharma, K, Browne, C.M, Klaus, C.R, Li, H, Massa, G, McDonald, A.A, Shi, Y, Sintchak, M, Skouras, S, Walther, D.M, Yuan, K, Zhang, Y, Kelleher, J, Guang, L, Luo, X, Mainolfi, N, Weiss, M.M. | | 登録日 | 2024-07-26 | | 公開日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases.
J.Med.Chem., 2024
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9CV0
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9CV9
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9CWS
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9D3E
 | | Cryo-EM structure of CCR6 bound by SQA1 and OXM2 | | 分子名称: | 4-[[3,4-bis(oxidanylidene)-2-[[(1~{R})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{N},~{N}-dimethyl-3-oxidanyl-pyridine-2-carboxamide, CHOLESTEROL, Human CCR6, ... | | 著者 | Wasilko, D.J, Wu, H. | | 登録日 | 2024-08-09 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Structural basis for CCR6 modulation by allosteric antagonists.
Nat Commun, 15, 2024
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9D3G
 | | Cryo-EM structure of CCR6 bound by SQA1 and OXM1 | | 分子名称: | 1-(4-chlorophenyl)-N-{[(2R)-4-(2,3-dihydro-1H-inden-2-yl)-5-oxomorpholin-2-yl]methyl}cyclopropane-1-carboxamide, 4-[[3,4-bis(oxidanylidene)-2-[[(1~{R})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{N},~{N}-dimethyl-3-oxidanyl-pyridine-2-carboxamide, CCR6, ... | | 著者 | Wasilko, D.J, Wu, H. | | 登録日 | 2024-08-10 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Structural basis for CCR6 modulation by allosteric antagonists.
Nat Commun, 15, 2024
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9D5D
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