9J8T
 
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9J8U
 
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9P6P
 
 | Crystal Structure of the SARS-CoV-2 2'-O-Methyltransferase with (m7GpppA)pUpU (Cap-0) and S-Adenosyl-L-homocysteine (SAH). | Descriptor: | 2'-O-methyltransferase, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | Authors: | Minasov, G, Shuvalova, L, Maltseva, N, Kim, Y, Kiryukhina, O, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID) | Deposit date: | 2025-06-19 | Release date: | 2025-07-02 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of the SARS-CoV-2 2'-O-Methyltransferase with (m7GpppA)pUpU (Cap-0) and S-Adenosyl-L-homocysteine (SAH). To Be Published
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9CJO
 
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9CJP
 
 | X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Nirmatrelvir | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 1,2-ETHANEDIOL, 3C-like proteinase nsp5, ... | Authors: | Esler, M.A, Shi, K, Harris, R.S, Aihara, H. | Deposit date: | 2024-07-07 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Nirmatrelvir To Be Published
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9CJQ
 
 | X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Ensitrelvir | Descriptor: | 1,2-ETHANEDIOL, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, main protease | Authors: | Esler, M.A, Shi, K, Harris, R.S, Aihara, H. | Deposit date: | 2024-07-07 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Ensitrelvir To Be Published
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9CJR
 
 | X-ray crystal structure of SARS-CoV-2 main protease double mutants in complex with Ensitrelvir | Descriptor: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, CHLORIDE ION, ... | Authors: | Esler, M.A, Shi, K, Harris, R.S, Aihara, H. | Deposit date: | 2024-07-07 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | X-ray crystal structure of SARS-CoV-2 main protease double mutants in complex with Ensitrelvir To Be Published
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9CJS
 
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9CJT
 
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9CJU
 
 | Structure of SARS-CoV-2 main protease in complex with Bofutrelvir in orthorhombic form | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Non-structural protein 7, ... | Authors: | Esler, M.A, Shi, K, Harris, R.S, Aihara, H. | Deposit date: | 2024-07-07 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | To be published To Be Published
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9CJV
 
 | X-ray crystal structure of SARS-CoV-2 main protease complex with Bofutrelvir | Descriptor: | 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide | Authors: | Esler, M.A, Shi, K, Aihara, H. | Deposit date: | 2024-07-07 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | X-ray crystal structure of SARS-CoV-2 main protease complex with Bofutrelvir To Be Published
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9E9Q
 
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9FWH
 
 | Crystal Structure of SARS-CoV-2 NSP10-ExoN in complex with VT00019 | Descriptor: | (4R)-4-phenyl-1,2-thiazolidine 1,1-dioxide, Guanine-N7 methyltransferase nsp14, Non-structural protein 10, ... | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | Deposit date: | 2024-06-30 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal Structure of SARS-CoV-2 NSP10-ExoN in complex with VT00019 To Be Published
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9FWI
 
 | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00025 | Descriptor: | (3-oxidanylazetidin-1-yl)-phenyl-methanone, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ... | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | Deposit date: | 2024-06-30 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (1.533 Å) | Cite: | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00025 To Be Published
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9FWJ
 
 | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00079 | Descriptor: | 2-methoxybenzamide, Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, ... | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | Deposit date: | 2024-06-30 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (2.424 Å) | Cite: | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00079 To Be Published
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9FWL
 
 | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00025 | Descriptor: | 3-phenylthiophene-2-carboxamide, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ... | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | Deposit date: | 2024-06-30 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00025 To Be Published
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9FWM
 
 | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00180 | Descriptor: | 1H-indole-3-carboxamide, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ... | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | Deposit date: | 2024-06-30 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (1.574 Å) | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00180 To Be Published
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9FWN
 
 | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00219 | Descriptor: | 1-methyl-1-(phenylmethyl)urea, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ... | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | Deposit date: | 2024-06-30 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (1.866 Å) | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00219 To Be Published
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9FWO
 
 | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00216 | Descriptor: | 1-methylpyrrole-2-carboxamide, Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, ... | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | Deposit date: | 2024-06-30 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (2.179 Å) | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00216 To Be Published
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9FWP
 
 | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00198 | Descriptor: | Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, N-methylbenzamide, ... | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | Deposit date: | 2024-06-30 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (2.381 Å) | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00198 To Be Published
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9FWQ
 
 | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00218 | Descriptor: | 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine, Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, ... | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | Deposit date: | 2024-06-30 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (2.322 Å) | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00218 To Be Published
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9FWR
 
 | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00249 | Descriptor: | (4R)-4-phenyl-1,3-oxazolidin-2-one, Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, ... | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | Deposit date: | 2024-06-30 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (2.294 Å) | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00249 To Be Published
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9FWS
 
 | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00258 | Descriptor: | 7-METHOXY-1H-INDAZOLE, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ... | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | Deposit date: | 2024-06-30 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (1.433 Å) | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00258 To Be Published
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9FWT
 
 | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00259 | Descriptor: | DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, Non-structural protein 10, ... | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | Deposit date: | 2024-06-30 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (1.639 Å) | Cite: | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00259 To Be Published
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9FWU
 
 | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00421 | Descriptor: | DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, N,N-dimethyl-3-oxidanyl-benzamide, ... | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | Deposit date: | 2024-06-30 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (1.425 Å) | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00421 To Be Published
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