9J8U

Crystal structure of SARS-CoV-2 main protease in complex with Mp-4D7

Summary for 9J8U

• Entry DOI: 10.2210/pdb9j8u/pdb
• Descriptor: 3C-like proteinase nsp5, DTY-VAL-THR-PHE-HIS-ALO-2TL-2TL-PRO-PHE-LEU-DPR-PRO-CCJ-GLY-NH2 (3 entities in total)
• Functional Keywords: inhibitor, sars-cov-2, complex, main protease, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 2
• Total formula weight: 35563.52

Authors

Shi, Y.S.,Yang, J.Y.,Wang, M.W. (deposition date: 2024-08-21, release date: 2025-07-02)

• Primary citation: Yin, Y.Y.,Shi, Y.S.,Qi, J.Q.,Tan, Y.T.,Yang, J.Y.,Wang, M.W.,Peng, Q.P.,Li, Y.L.,Fu, L.F.,Zhang, M.Z.,Zhang, Y.Z.; De novo discovery of a non-covalent cell-penetrating bicyclic pep-tide inhibitor targeting SARS-CoV-2 main protease; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.71 Å)