9J8T
 
 | |
9J8U
 | |
9P6P
 | | Crystal Structure of the SARS-CoV-2 2'-O-Methyltransferase with (m7GpppA)pUpU (Cap-0) and S-Adenosyl-L-homocysteine (SAH). | | Descriptor: | 2'-O-methyltransferase, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | | Authors: | Minasov, G, Shuvalova, L, Maltseva, N, Kim, Y, Kiryukhina, O, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2025-06-19 | | Release date: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal Structure of the SARS-CoV-2 2'-O-Methyltransferase with (m7GpppA)pUpU (Cap-0) and S-Adenosyl-L-homocysteine (SAH).
To Be Published
|
|
9CJO
 | |
9CJP
 | | X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Nirmatrelvir | | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 1,2-ETHANEDIOL, 3C-like proteinase nsp5, ... | | Authors: | Esler, M.A, Shi, K, Harris, R.S, Aihara, H. | | Deposit date: | 2024-07-07 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Nirmatrelvir
To Be Published
|
|
9CJQ
 | | X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Ensitrelvir | | Descriptor: | 1,2-ETHANEDIOL, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, main protease | | Authors: | Esler, M.A, Shi, K, Harris, R.S, Aihara, H. | | Deposit date: | 2024-07-07 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Ensitrelvir
To Be Published
|
|
9CJR
 | | X-ray crystal structure of SARS-CoV-2 main protease double mutants in complex with Ensitrelvir | | Descriptor: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, CHLORIDE ION, ... | | Authors: | Esler, M.A, Shi, K, Harris, R.S, Aihara, H. | | Deposit date: | 2024-07-07 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | X-ray crystal structure of SARS-CoV-2 main protease double mutants in complex with Ensitrelvir
To Be Published
|
|
9CJS
 | |
9CJT
 | |
9CJU
 | | Structure of SARS-CoV-2 main protease in complex with Bofutrelvir in orthorhombic form | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Non-structural protein 7, ... | | Authors: | Esler, M.A, Shi, K, Harris, R.S, Aihara, H. | | Deposit date: | 2024-07-07 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | To be published
To Be Published
|
|
9CJV
 | | X-ray crystal structure of SARS-CoV-2 main protease complex with Bofutrelvir | | Descriptor: | 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide | | Authors: | Esler, M.A, Shi, K, Aihara, H. | | Deposit date: | 2024-07-07 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | X-ray crystal structure of SARS-CoV-2 main protease complex with Bofutrelvir
To Be Published
|
|
9E9Q
 | |
9FWH
 | | Crystal Structure of SARS-CoV-2 NSP10-ExoN in complex with VT00019 | | Descriptor: | (4R)-4-phenyl-1,2-thiazolidine 1,1-dioxide, Guanine-N7 methyltransferase nsp14, Non-structural protein 10, ... | | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | | Deposit date: | 2024-06-30 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Crystal Structure of SARS-CoV-2 NSP10-ExoN in complex with VT00019
To Be Published
|
|
9FWI
 | | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00025 | | Descriptor: | (3-oxidanylazetidin-1-yl)-phenyl-methanone, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ... | | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | | Deposit date: | 2024-06-30 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.533 Å) | | Cite: | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00025
To Be Published
|
|
9FWJ
 | | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00079 | | Descriptor: | 2-methoxybenzamide, Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, ... | | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | | Deposit date: | 2024-06-30 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.424 Å) | | Cite: | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00079
To Be Published
|
|
9FWL
 | | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00025 | | Descriptor: | 3-phenylthiophene-2-carboxamide, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ... | | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | | Deposit date: | 2024-06-30 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00025
To Be Published
|
|
9FWM
 | | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00180 | | Descriptor: | 1H-indole-3-carboxamide, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ... | | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | | Deposit date: | 2024-06-30 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.574 Å) | | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00180
To Be Published
|
|
9FWN
 | | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00219 | | Descriptor: | 1-methyl-1-(phenylmethyl)urea, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ... | | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | | Deposit date: | 2024-06-30 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.866 Å) | | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00219
To Be Published
|
|
9FWO
 | | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00216 | | Descriptor: | 1-methylpyrrole-2-carboxamide, Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, ... | | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | | Deposit date: | 2024-06-30 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.179 Å) | | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00216
To Be Published
|
|
9FWP
 | | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00198 | | Descriptor: | Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, N-methylbenzamide, ... | | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | | Deposit date: | 2024-06-30 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.381 Å) | | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00198
To Be Published
|
|
9FWQ
 | | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00218 | | Descriptor: | 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine, Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, ... | | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | | Deposit date: | 2024-06-30 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.322 Å) | | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00218
To Be Published
|
|
9FWR
 | | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00249 | | Descriptor: | (4R)-4-phenyl-1,3-oxazolidin-2-one, Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, ... | | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | | Deposit date: | 2024-06-30 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.294 Å) | | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00249
To Be Published
|
|
9FWS
 | | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00258 | | Descriptor: | 7-METHOXY-1H-INDAZOLE, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ... | | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | | Deposit date: | 2024-06-30 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.433 Å) | | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00258
To Be Published
|
|
9FWT
 | | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00259 | | Descriptor: | DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, Non-structural protein 10, ... | | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | | Deposit date: | 2024-06-30 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.639 Å) | | Cite: | Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00259
To Be Published
|
|
9FWU
 | | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00421 | | Descriptor: | DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, N,N-dimethyl-3-oxidanyl-benzamide, ... | | Authors: | Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W. | | Deposit date: | 2024-06-30 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.425 Å) | | Cite: | Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00421
To Be Published
|
|
