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冠状病毒
冠状病毒,2020. 由David S. Goodsell @ RCSB PDB原图修改

最近爆发的新型冠状病毒传染病(Novel Coronavirus disease 2019: COVID-19)对全世界的人们都构成了严重威胁。 为了尽早了解新病毒(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)以开发出有效的抗病毒药物,已经有很多科研人員开始了相关蛋白结构的研究,并且将所获得的结构数据存储于PDB。 PDBj为用户提供了COVID-19相关数据一览的门户页面,并将于每周三更新当日新发布的相关数据。

有关该病毒蛋白质的解说,请参见下面的“当月的分子”页面。

“所有结构”标签的页面则逐一罗列了所有的结构数据,包括由同一研究组提交的系列数据群。 “代表性结构”标签的页面精选具有相同氨基酸序列的结构数据中的高分辨率数据,不重复选择具同一氨基酸序列的数据,即使该数据可能包含不同配体。 “最新条目”标签内包含本周新更新数据。

Created: 2020-03-11 (last edited: 1 month ago)2020-09-03
所有结构 (502)代表性结构 (209)最新条目 (13)
7K8V
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STRUCTURE OF THE SARS-COV-2 S 2P TRIMER IN COMPLEX WITH THE HUMAN NEUTRALIZING ANTIBODY FAB FRAGMENT, C110
Descriptor:Spike glycoprotein, C110 Fab Heavy Chain, C110 Fab Light Chain, ...
Authors:Dam, K.A., Barnes, C.O., Bjorkman, P.J.
Deposit date:2020-09-27
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 2020
7K8T
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STRUCTURE OF THE SARS-COV-2 S 2P TRIMER IN COMPLEX WITH THE HUMAN NEUTRALIZING ANTIBODY FAB FRAGMENT, C002 (STATE 1)
Descriptor:Spike glycoprotein, C002 Fab Heavy Chain, C002 Fab Light Chain, ...
Authors:Malyutin, A.G., Barnes, C.O., Bjorkman, P.J.
Deposit date:2020-09-27
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 2020
7K8S
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STRUCTURE OF THE SARS-COV-2 S 2P TRIMER IN COMPLEX WITH THE HUMAN NEUTRALIZING ANTIBODY FAB FRAGMENT, C002 (STATE 1)
Descriptor:Spike glycoprotein, C002 Fab Heavy Chain, C002 Fab Light Chain, ...
Authors:Barnes, C.O., Malyutin, A.G., Bjorkman, P.J.
Deposit date:2020-09-27
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 2020
7K9P
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ROOM TEMPERATURE STRUCTURE OF NSP15 ENDORIBONUCLEASE FROM SARS COV-2 SOLVED USING SFX.
Descriptor:Uridylate-specific endoribonuclease, CITRIC ACID
Authors:Botha, S., Jernigan, R., Chen, J., Coleman, M.A., Frank, M., Grant, T.D., Hansen, D.T., Ketawala, G., Logeswaran, D., Martin-Garcia, J., Nagaratnam, N., Raj, A.L.L.X., Shelby, M., Yang, J.-H., Yung, M.C., Fromme, P.
Deposit date:2020-09-29
Release date:2020-10-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Room temperature structure of NendoU (Uridylate-specific endoribonuclease, Nsp15) solved using SFX.
To Be Published
7K8U
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STRUCTURE OF THE SARS-COV-2 S 2P TRIMER IN COMPLEX WITH THE HUMAN NEUTRALIZING ANTIBODY FAB FRAGMENT, C002 (STATE 1)
Descriptor:Spike glycoprotein, C104 Fab Heavy Chain, C104 Fab Light Chain, ...
Authors:Barnes, C.O., Malyutin, A.G., Bjorkman, P.J.
Deposit date:2020-09-27
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies
Nature, 2020
7KDT
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HUMAN TOM70 IN COMPLEX WITH SARS COV2 ORF9B
Descriptor:Mitochondrial import receptor subunit TOM70, ORF9b protein
Authors:QCRG Structural Biology Consortium
Deposit date:2020-10-09
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Comparative Host-Coronavirus Protein Interaction Networks Reveal Pan-Viral Disease Mechanisms
Science, 2020
7K8W
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STRUCTURE OF THE SARS-COV-2 S 2P TRIMER IN COMPLEX WITH THE HUMAN NEUTRALIZING ANTIBODY FAB FRAGMENT, C119
Descriptor:Spike glycoprotein, C119 Fab Heavy Chain, C119 Fab Light Chain, ...
Authors:Sharaf, N.G., Barnes, C.O., Bjorkman, P.J.
Deposit date:2020-09-27
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 2020
7K8Z
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STRUCTURE OF THE SARS-COV-2 S 2P TRIMER IN COMPLEX WITH THE HUMAN NEUTRALIZING ANTIBODY FAB FRAGMENT, C135
Descriptor:Spike glycoprotein, C135 Fab Heavy Chain, C135 Fab Light Chain, ...
Authors:Barnes, C.O., Bjorkman, P.J.
Deposit date:2020-09-27
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies
Nature, 2020
7K8Y
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STRUCTURE OF THE SARS-COV-2 S 2P TRIMER IN COMPLEX WITH THE HUMAN NEUTRALIZING ANTIBODY FAB FRAGMENT, C121 (STATE 2)
Descriptor:Spike glycoprotein, C121 Fab Heavy chain, C121 Fab Light chain, ...
Authors:Abernathy, M.E., Barnes, C.O., Bjorkman, P.J.
Deposit date:2020-09-27
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies
Nature, 2020
7K8X
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STRUCTURE OF THE SARS-COV-2 S 2P TRIMER IN COMPLEX WITH THE HUMAN NEUTRALIZING ANTIBODY FAB FRAGMENT, C121 (STATE 1)
Descriptor:Spike glycoprotein, C121 Fab Heavy chain, C121 Fab Light chain, ...
Authors:Abernathy, M.E., Barnes, C.O., Bjorkman, P.J.
Deposit date:2020-09-27
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies
Nature, 2020
7A29
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CRYO-EM STRUCTURE OF THE SARS-COV-2 SPIKE PROTEIN BOUND TO NEUTRALIZING SYBODIES (SB23) 2-UP CONFORMATION
Descriptor:Spike glycoprotein, Neutralising sybody (Sb23), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Hallberg, B.M., Das, H.
Deposit date:2020-08-16
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2
BiorXiv, 2020
7K8M
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CRYSTAL STRUCTURE OF AN ANTI-SARS-COV-2 HUMAN NEUTRALIZING ANTIBODY FAB FRAGMENT, C110
Descriptor:C102 Fab Heavy Chain, C102 Fab Light Chain, Surface glycoprotein, ...
Authors:Jette, C.A., Barnes, C.O., Bjorkman, P.J.
Deposit date:2020-09-27
Release date:2020-10-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 2020
7K90
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STRUCTURE OF THE SARS-COV-2 S 6P TRIMER IN COMPLEX WITH THE HUMAN NEUTRALIZING ANTIBODY FAB FRAGMENT, C144
Descriptor:Spike glycoprotein, C144 Fab Heavy Chain, C144 Fab Light Chain, ...
Authors:Barnes, C.O., Esswein, S.R., Bjorkman, P.J.
Deposit date:2020-09-27
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 2020
7JX3
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MAPPING NEUTRALIZING AND IMMUNODOMINANT SITES ON THE SARS-COV-2 SPIKE RECEPTOR-BINDING DOMAIN BY STRUCTURE-GUIDED HIGH-RESOLUTION SEROLOGY
Descriptor:Light chain of Fab domain of monoclonal antibody S309, Heavy chain of Fab domain of monoclonal antibody S309, Light chain of Fab domain of monoclonal antibody S2H14, ...
Authors:Snell, G., Czudnochowski, N., Rosen, L.E., Nix, J.C., Corti, D., Veesler, D., Park, Y.J., Walls, A.C., Tortorici, M.A., Cameroni, E., Pinto, D., Beltramello, M.
Deposit date:2020-08-26
Release date:2020-10-14
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7JV4
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S2H13 NEUTRALIZING ANTIBODY (ONE RBD OPEN)
Descriptor:SARS-CoV-2 spike glycoprotein, S2H13 Fab heavy chain, S2H13 Fab light chain, ...
Authors:Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-20
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7JVA
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S2A4 NEUTRALIZING ANTIBODY FAB FRAGMENT (LOCAL REFINEMENT OF THE RECEPTOR-BINDING DOMAIN AND FAB VARIABLE DOMAINS)
Descriptor:S2A4 Fab heavy chain, S2A4 Fab light chain, SARS-CoV-2 spike glycoprotein, ...
Authors:Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-20
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
6XKQ
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CRYSTAL STRUCTURE OF SARS-COV-2 RECEPTOR BINDING DOMAIN IN COMPLEX WITH NEUTRALIZING ANTIBODY CV07-250
Descriptor:Spike protein S1, CV07-250 Heavy Chain, CV07-250 Light Chain, ...
Authors:Yuan, M., Liu, H., Zhu, X., Wu, N.C., Wilson, I.A.
Deposit date:2020-06-26
Release date:2020-10-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model
Cell(Cambridge,Mass.), 2020
6ZPE
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NONSTRUCTURAL PROTEIN 10 (NSP10) FROM SARS COV-2
Descriptor:Replicase polyprotein 1ab, ZINC ION, GLYCEROL, ...
Authors:Fisher, S.Z., Kozielski, F.
Deposit date:2020-07-08
Release date:2020-10-14
Last modified:2020-10-21
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2.
Int J Mol Sci, 21, 2020
7JV2
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S2H13 NEUTRALIZING ANTIBODY FAB FRAGMENT (LOCAL REFINEMENT OF THE RECEPTOR-BINDING MOTIF AND FAB VARIABLE DOMAINS)
Descriptor:S2H13 Fab heavy chain, S2H13 Fab light chain, SARS-CoV-2 spike glycoprotein
Authors:Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-20
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7JV6
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S2H13 NEUTRALIZING ANTIBODY (CLOSED CONFORMATION)
Descriptor:SARS-CoV-2 spike glycoprotein, S2H13 Fab heavy chain, S2H13 Fab light chain, ...
Authors:Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-20
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7JW0
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S304 NEUTRALIZING ANTIBODY FAB FRAGMENT
Descriptor:SARS-CoV-2 spike glycoprotein, S304 Fab light chain, S304 Fab heavy chain, ...
Authors:Walls, A.C., Park, Y.J., Tortorici, M.A., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-24
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7K5I
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SARS-COV-2 NSP1 IN COMPLEX WITH HUMAN 40S RIBOSOME
Descriptor:40S ribosomal protein S17, 40S ribosomal rRNA18S, 40S ribosomal protein S29, ...
Authors:Wang, L., Shi, M., Wu, H.
Deposit date:2020-09-16
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism.
Biorxiv, 2020
7JVC
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S2A4 NEUTRALIZING ANTIBODY FAB FRAGMENT
Descriptor:SARS-CoV-2 spike glycoprotein, S2A4 Fab heavy chain, S2A4 Fab light chain, ...
Authors:Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-20
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
6XKP
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CRYSTAL STRUCTURE OF SARS-COV-2 RECEPTOR BINDING DOMAIN IN COMPLEX WITH NEUTRALIZING ANTIBODY CV07-270
Descriptor:Spike protein S1, CV07-270 Heavy Chain, CV07-270 Light Chain, ...
Authors:Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A.
Deposit date:2020-06-26
Release date:2020-10-14
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model
Cell(Cambridge,Mass.), 2020
7JMW
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CRYSTAL STRUCTURE OF SARS-COV-2 SPIKE PROTEIN RECEPTOR-BINDING DOMAIN IN COMPLEX WITH CROSS-NEUTRALIZING ANTIBODY COVA1-16 FAB
Descriptor:Spike protein S1, COVA1-16 heavy chain, COVA1-16 light chain, ...
Authors:Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A.
Deposit date:2020-08-03
Release date:2020-10-14
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:cross-neutralizing antibody
To Be Published
170172
数据于2020-10-21公开中