6Y2E

Crystal structure of the free enzyme of the SARS-CoV-2 (2019-nCoV) main protease

Summary for 6Y2E

Entry DOI	10.2210/pdb6y2e/pdb
Descriptor	3C-like proteinase (2 entities in total)
Functional Keywords	novel coronavirus, alpha-ketoamide, antiviral, drug design, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
Total number of polymer chains	1
Total formula weight	33825.55
Authors	Zhang, L.,Sun, X.,Hilgenfeld, R. (deposition date: 2020-02-15, release date: 2020-03-04, Last modification date: 2024-01-24)
Primary citation	Zhang, L.,Lin, D.,Sun, X.,Curth, U.,Drosten, C.,Sauerhering, L.,Becker, S.,Rox, K.,Hilgenfeld, R. Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors. Science, 368:409-412, 2020 Cited by PubMed: 32198291 DOI: 10.1126/science.abb3405 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation