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코로나 바이러스
코로나 바이러스, 2020. David S. Goodsell @ RCSB PDB에 의한 오리지널 일러스트를 수정

신종 코로나바이러스 감염증 (Novel Coronavirus disease 2019:COVID-19)의 확산이 세계적으로 매우 큰 문제가 되고 있습니다. 시급히 새로운 바이러스(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)를 이해하고 효과적인 약을 개발하기 위해, 신속하게 구조 생물학 연구가 시작되고 있습니다. PDBj는 사용자의 편의를 도모하기 위해 신종 코로나바이러스의 특집 페이지를 제공하고 있습니다. 매주 수요일에 최신 항목이 추가됩니다.

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Created: 2020-03-11 (last edited: 3 days ago)2020-06-30
대표구조 (98)전체 엔트리
6XE1
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STRUCTURE OF SARS-COV-2 SPIKE PROTEIN RECEPTOR BINDING DOMAIN IN COMPLEX WITH A POTENT NEUTRALIZING ANTIBODY, CV30 FAB
Descriptor:CV30 Fab Heavy chain, CV30 Fab Kappa chain, Spike protein S1, ...
Authors:Hurlburt, N.K., Pancera, M.
Deposit date:2020-06-11
Release date:2020-07-01
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation
To Be Published
6XIP
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THE 1.5 A CRYSTAL STRUCTURE OF THE CO-FACTOR COMPLEX OF NSP7 AND THE C-TERMINAL DOMAIN OF NSP8 FROM SARS COV-2
Descriptor:Non-structural protein 7, Non-structural protein 8, 1,2-ETHANEDIOL
Authors:Wilamowski, M., Kim, Y., Jedrzejczak, R., Maltseva, N., Endres, M., Godzik, A., Michalska, K., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-06-20
Release date:2020-07-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The 1.5 A Crystal Structure of the Co-factor Complex of NSP7 and the C-terminal Domain of NSP8 from SARS CoV-2
To Be Published
6XCM
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STRUCTURE OF THE SARS-COV-2 SPIKE GLYCOPROTEIN IN COMPLEX WITH THE C105 NEUTRALIZING ANTIBODY FAB FRAGMENT (STATE 1)
Descriptor:Spike glycoprotein, C105 Fab Heavy Chain, C105 Fab Light Chain, ...
Authors:Barnes, C.O., Bjorkman, P.J.
Deposit date:2020-06-08
Release date:2020-07-01
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies
Cell(Cambridge,Mass.), 2020
7C2L
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S PROTEIN OF SARS-COV-2 IN COMPLEX BOUND WITH 4A8
Descriptor:Spike glycoprotein, heavy chain of 4A8, light chain of 4A8, ...
Authors:Yan, R.H., Zhang, Y.Y., Guo, Y.Y., Li, Y.N., Xia, L., Zhou, Q.
Deposit date:2020-05-08
Release date:2020-07-01
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2
Science, 2020
6Z97
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STRUCTURE OF THE PREFUSION SARS-COV-2 SPIKE GLYCOPROTEIN
Descriptor:Spike glycoprotein,Fibritin, N-ACETYL-D-GLUCOSAMINE
Authors:Duyvesteyn, H.M.E., Ren, J., Zhao, Y., Zhou, D., Huo, J., Carrique, L., Malinauskas, T., Ruza, R.R., Shah, P.N.M., Fry, E.E., Owens, R., Stuart, D.I.
Deposit date:2020-06-03
Release date:2020-07-01
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Neutralization of SARS-CoV-2 by destruction of the prefusion Spike
To Be Published
6ZDH
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SARS-COV-2 SPIKE GLYCOPROTEIN IN COMPLEX WITH A NEUTRALIZING ANTIBODY EY6A FAB
Descriptor:Spike glycoprotein, EY6A heavy chain, EY6A light chain, ...
Authors:Duyvesteyn, H.M.E., Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I.
Deposit date:2020-06-14
Release date:2020-07-01
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient
To Be Published
6ZCO
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CRYSTAL STRUCTURE OF C-TERMINAL DIMERIZATION DOMAIN OF NUCLEOCAPSID PHOSPHOPROTEIN FROM SARS-COV-2, CRYSTAL FORM II
Descriptor:Nucleoprotein
Authors:Zinzula, L., Basquin, J., Nagy, I., Bracher, A.
Deposit date:2020-06-11
Release date:2020-07-01
Method:X-RAY DIFFRACTION (1.361 Å)
Cite:Crystal Structure of C-terminal Dimerization Domain of Nucleocapsid Phosphoprotein from SARS-CoV-2, crystal form II
To Be Published
6ZGI
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FURIN CLEAVED SPIKE PROTEIN OF SARS-COV-2 IN CLOSED CONFORMATION
Descriptor:Spike glycoprotein, N-ACETYL-D-GLUCOSAMINE
Authors:Wrobel, A.G., Benton, D.J., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-06-18
Release date:2020-07-01
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Evolution of SARS-CoV-2 spike glycoprotein
To be published
6ZGE
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UNCLEAVABLE SPIKE PROTEIN OF SARS-COV-2 IN CLOSED CONFORMATION
Descriptor:Spike glycoprotein, N-ACETYL-D-GLUCOSAMINE
Authors:Wrobel, A.G., Benton, D.J., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-06-18
Release date:2020-07-01
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Evolution of SARS-CoV-2 spike glycoprotein
To be published
7CAN
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STRUCTURE OF SYBODY MR17-K99Y IN COMPLEX WITH THE SARS-COV-2 S RECEPTOR-BINDING DOMAIN (RBD)
Descriptor:sybody MR17-K99Y, Spike glycoprotein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Li, T., Yao, H., Cai, H., Qin, W., Li, D.
Deposit date:2020-06-09
Release date:2020-06-24
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Potent synthetic nanobodies against SARS-CoV-2 and molecular basis for neutratlization
To Be Published
6XDG
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COMPLEX OF SARS-COV-2 RECEPTOR BINDING DOMAIN WITH THE FAB FRAGMENTS OF TWO NEUTRALIZING ANTIBODIES
Descriptor:Spike glycoprotein, REGN10933 antibody Fab fragment light chain, REGN10933 antibody Fab fragment heavy chain, ...
Authors:Franklin, M.C., Saotome, K., Romero Hernandez, A., Zhou, Y.
Deposit date:2020-06-10
Release date:2020-06-24
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail.
Science, 2020
6ZER
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CRYSTAL STRUCTURE OF RECEPTOR BINDING DOMAIN OF SARS-COV-2 SPIKE GLYCOPROTEIN IN COMPLEX WITH EY6A FAB
Descriptor:RBD, heavy chain, light chain, ...
Authors:Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I.
Deposit date:2020-06-16
Release date:2020-06-24
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient
To Be Published
7C8W
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STRUCTURE OF SYBODY MR17 IN COMPLEX WITH THE SARS-COV-2 S RECEPTOR-BINDING DOMAIN (RBD)
Descriptor:Synthetic nanobody MR17, Spike glycoprotein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Li, T., Cai, H., Yao, H., Qin, W., Li, D.
Deposit date:2020-06-03
Release date:2020-06-24
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Rapid selection of synthetic nanobodies against the receptor binding domain of SARS-CoV-2 S protein
To Be Published
6ZCZ
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CRYSTAL STRUCTURE OF RECEPTOR BINDING DOMAIN OF SARS-COV-2 SPIKE GLYCOPROTEIN IN TERNARY COMPLEX WITH EY6A FAB AND A NANOBODY.
Descriptor:Spike glycoprotein, Nanobody, EY6A heavy chain, ...
Authors:Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I.
Deposit date:2020-06-12
Release date:2020-06-24
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient
To Be Published
6ZCT
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NONSTRUCTURAL PROTEIN 10 (NSP10) FROM SARS COV-2
Descriptor:nsp10, ZINC ION
Authors:Fisher, S.Z., Kozielski, F.
Deposit date:2020-06-12
Release date:2020-06-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:not published
To Be Published
7C8V
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STRUCTURE OF SYBODY SR4 IN COMPLEX WITH THE SARS-COV-2 S RECEPTOR BINDING DOMAIN (RBD)
Descriptor:Synthetic nanobody SR4, Spike glycoprotein, GLYCEROL, ...
Authors:Li, T., Yao, H., Cai, H., Qin, W., Li, D.
Deposit date:2020-06-03
Release date:2020-06-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Potent synthetic nanobodies against SARS-CoV-2 and molecular basis for neutratlization
To Be Published
6XDH
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CRYSTAL STRUCTURE OF NENDOU (URIDYLATE-SPECIFIC ENDORIBONUCLEASE, NSP15) FROM BETACORONAVIRUS SARS-COV-2
Descriptor:Uridylate-specific endoribonuclease, ACETATE ION, CITRIC ACID, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-06-10
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure of NendoU (Uridylate-specific endoribonuclease, nsp15) from Betacoronavirus SARS-CoV-2
to be published
6XAA
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SARS COV-2 PLPRO IN COMPLEX WITH UBIQUITIN PROPARGYLAMIDE
Descriptor:Papain-like protease, Ubiquitin-propargylamide, ZINC ION
Authors:Klemm, T., Calleja, D.J., Richardson, L.W., Lechtenberg, B.C., Komander, D.
Deposit date:2020-06-04
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:SARS CoV-2 PLpro in complex with ubiquitin propargylamide
To Be Published
6XBG
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CRYSTAL STRUCTURE OF THE SARS-COV-2 (COVID-19) MAIN PROTEASE IN COMPLEX WITH INHIBITOR UAW246
Descriptor:main protease, inhibitor UAW246, GLYCEROL, ...
Authors:Sacco, M., Ma, C., Wang, J., Chen, Y.
Deposit date:2020-06-05
Release date:2020-06-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW246
To Be Published
6Z4U
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X-RAY CRYSTALLOGRAPHIC STRUCTURE OF ORF9B FROM SARS-COV-2
Descriptor:Protein 9b, POLYETHYLENE GLYCOL (N=34)
Authors:Weeks, S.D., De Graef, S., Munawar, A.
Deposit date:2020-05-25
Release date:2020-06-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:X-ray Crystallographic Structure of Orf9b from SARS-CoV-2
To Be Published
6XBI
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CRYSTAL STRUCTURE OF THE SARS-COV-2 (COVID-19) MAIN PROTEASE IN COMPLEX WITH INHIBITOR UAW248
Descriptor:main protease, inhibitor UAW248, GLYCEROL, ...
Authors:Sacco, M., Ma, C., Wang, J., Chen, Y.
Deposit date:2020-06-06
Release date:2020-06-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW248
To Be Published
6XA4
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CRYSTAL STRUCTURE OF THE SARS-COV-2 (COVID-19) MAIN PROTEASE IN COMPLEX WITH UAW241
Descriptor:main protease, inhibitor UAW241, GLYCEROL
Authors:Sacco, M., Ma, C., Wang, J., Chen, Y.
Deposit date:2020-06-03
Release date:2020-06-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with UAW241
To Be Published
7BQ7
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CRYSTAL STRUCTURE OF 2019-NCOV NSP16-NSP10 COMPLEX
Descriptor:SARS-CoV-2 nsp16, SARS-CoV-2 nsp10, S-ADENOSYLMETHIONINE, ...
Authors:Yan, L.M., Huang, Y.C., Lou, Z.Y., Rao, Z.H.
Deposit date:2020-03-24
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Crystal structure of 2019-nCoV nsp16-nsp10 complex
To Be Published
6XA9
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SARS COV-2 PLPRO IN COMPLEX WITH ISG15 C-TERMINAL DOMAIN PROPARGYLAMIDE
Descriptor:Papain-like protease, ISG15 CTD-propargylamide, GLYCEROL, ...
Authors:Klemm, T., Calleja, D.J., Richardson, L.W., Lechtenberg, B.C., Komander, D.
Deposit date:2020-06-04
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:SARS CoV-2 PLpro in complex with ISG15 C-terminal domain propargylamide
To Be Published
6M5I
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CRYSTAL STRUCTURE OF 2019-NCOV NSP7-NSP8C COMPLEX
Descriptor:SARS-CoV-2 nsp8, SARS-CoV-2 nsp7
Authors:Yan, L.M., Ge, J., Zhao, Y., Lou, Z.Y., Rao, Z.H.
Deposit date:2020-03-10
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2.496 Å)
Cite:Crystal structure of 2019-nCoV nsp7-nsp8c complex
To Be Published