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신종 코로나바이러스 특집 콘텐츠

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코로나 바이러스
코로나 바이러스, 2020. David S. Goodsell @ RCSB PDB에 의한 오리지널 일러스트를 수정

신종 코로나바이러스 감염증 (Novel Coronavirus disease 2019:COVID-19)의 확산이 세계적으로 매우 큰 문제가 되고 있습니다. 시급히 새로운 바이러스(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)를 이해하고 효과적인 약을 개발하기 위해, 신속하게 구조 생물학 연구가 시작되고 있습니다. PDBj는 사용자의 편의를 도모하기 위해 신종 코로나바이러스의 특집 페이지를 제공하고 있습니다. 매주 수요일에 최신 항목이 추가됩니다.

바이러스 단백질에 관한 해설기사는 아래의 「이달의 분자」 페이지를 참조하십시오.

「전체 엔트리」 탭에는, 모든 PDB ID가 포함되어 있습니다. 이용자가 전체의 독립된 엔트리를 검색하고 싶을 때 사용하실 수 있으며, 동일 저자에 의한 그룹등록의 엔트리도 전부 구별되어 있습니다. 「대표구조」 탭에는, 분해능이 가장 높은 대표구조만을 표지하고 있습니다. 아미노산 서열이 100 % 일치하는 PDB 엔트리의 경우, 다른 리간드를 포함하여도 대표구조에는 제외됩니다. 「최신 엔트리」 탭은, 이번주 공개된 가장 최근의 엔트리 입니다.


Created: 2020-09-03 (last edited: more than 1 year ago)2022-09-02
7M71
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BU of 7m71 by Molmil
SARS-CoV-2 Spike:5A6 Fab complex I focused refinement
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 5A6 Fab heavy chain, Antibody 5A6 Fab light chain, ...
Authors:Asarnow, D, Cheng, Y.
Deposit date:2021-03-26
Release date:2021-05-26
Last modified:2021-06-23
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.
Cell, 184, 2021
7M7B
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BU of 7m7b by Molmil
SARS-CoV-2 Spike:Fab 3D11 complex focused refinement
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab 3D11 heavy chain, Antibody Fab 3D11 light chain, ...
Authors:Asarnow, D, Cheng, Y.
Deposit date:2021-03-27
Release date:2021-05-26
Last modified:2021-06-23
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.
Cell, 184, 2021
7MKB
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BU of 7mkb by Molmil
Human leukocyte antigen A*0201 in complex with SARS-CoV-2 epitope YLQPRTFLL
Descriptor: Beta-2-microglobulin, GLYCEROL, MHC class I antigen, ...
Authors:Nyovanie, S.T, Patskovsky, Y, Krogsgaard, M.
Deposit date:2021-04-22
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Human leukocyte antigen A*0201 in complex with SARS-CoV-2 epitope YLQPRTFLL
To be Published
7MKY
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BU of 7mky by Molmil
SARS-CoV-2 frameshifting pseudoknot RNA
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, COBALT HEXAMMINE(III), MAGNESIUM ION, ...
Authors:Jones, C.P, Ferre-D'Amare, A.R.
Deposit date:2021-04-27
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot.
Rna, 28, 2022
7MSW
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BU of 7msw by Molmil
Full length SARS-CoV-2 Nsp2
Descriptor: Non-structural protein 2, ZINC ION
Authors:QCRG Structural Biology Consortium
Deposit date:2021-05-12
Release date:2021-05-26
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
To Be Published
7MSX
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BU of 7msx by Molmil
SARS-CoV-2 Nsp2
Descriptor: Non-structural protein 2, ZINC ION
Authors:QCRG Structural Biology Consortium
Deposit date:2021-05-12
Release date:2021-05-26
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
To Be Published
7BAJ
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BU of 7baj by Molmil
Crystal structure of ligand-free SARS-CoV-2 main protease
Descriptor: Main Protease
Authors:Amporndanai, K, O'Neill, P.M, Hasnain, S.S.
Deposit date:2020-12-15
Release date:2021-06-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives.
Nat Commun, 12, 2021
7BAK
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BU of 7bak by Molmil
Crystal structure of SARS-CoV-2 main protease treated with ebselen
Descriptor: Main Protease, SELENIUM ATOM
Authors:Amporndanai, K, O'Neill, P.M, Hasnain, S.S.
Deposit date:2020-12-15
Release date:2021-06-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives.
Nat Commun, 12, 2021
7BAL
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BU of 7bal by Molmil
Crystal structure of SARS-CoV-2 main protease treated with ebselen derivative of MR6-31-2
Descriptor: Main Protease, SELENIUM ATOM
Authors:Amporndanai, K, O'Neill, P.M, Hasnain, S.S.
Deposit date:2020-12-15
Release date:2021-06-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives.
Nat Commun, 12, 2021
7DZW
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BU of 7dzw by Molmil
Apo spike protein from SARS-CoV2
Descriptor: Spike glycoprotein
Authors:Liu, Y, Soh, W.T, Li, S, Kishikawa, J, Hirose, M, Kato, T, Standley, D, Okada, M, Arase, H.
Deposit date:2021-01-26
Release date:2021-06-02
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies.
Cell, 184, 2021
7DZX
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BU of 7dzx by Molmil
Spike protein from SARS-CoV2 with Fab fragment of enhancing antibody 8D2
Descriptor: Fab Heavy chain of enhancing antibody, Fab light chain of enhancing antibody, Spike glycoprotein
Authors:Liu, Y, Soh, W.T, Li, S, Kishikawa, J, Hirose, M, Kato, T, Standley, D, Okada, M, Arase, H.
Deposit date:2021-01-26
Release date:2021-06-02
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies.
Cell, 184, 2021
7DZY
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BU of 7dzy by Molmil
Spike protein from SARS-CoV2 with Fab fragment of enhancing antibody 2490
Descriptor: Fab Heavy chain of enhancing antibody 2490, Fab light chain of enhancing antibody 2490, Spike glycoprotein
Authors:Liu, Y, Soh, W.T, Li, S, Kishikawa, J, Hirose, M, Kato, T, Standley, D, Okada, M, Arase, H.
Deposit date:2021-01-26
Release date:2021-06-02
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies.
Cell, 184, 2021
7MFU
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BU of 7mfu by Molmil
Crystal structure of synthetic nanobody (Sb14+Sb68) complexes with SARS-CoV-2 receptor binding domain
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Spike protein S1, ...
Authors:Jiang, J, Ahmad, J, Natarajan, K, Boyd, L.F, Margulies, D.H.
Deposit date:2021-04-11
Release date:2021-06-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of synthetic nanobody-SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interaction.
J.Biol.Chem., 297, 2021
7N06
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BU of 7n06 by Molmil
SARS-CoV-2 Nsp15 endoribonuclease post-cleavage state
Descriptor: RNA (5'-R(*AP*UP*A)-3'), Uridylate-specific endoribonuclease
Authors:Frazier, M.N, Dillard, L.B, Krahn, J.M, Stanley, R.E.
Deposit date:2021-05-25
Release date:2021-06-02
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U.
Nucleic Acids Res., 49, 2021
7N0G
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BU of 7n0g by Molmil
CryoEm structure of SARS-CoV-2 spike protein (S-6P, 1-up) in complex with sybodies (Sb45)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Jiang, J, Huang, R, Margulies, D.
Deposit date:2021-05-25
Release date:2021-06-02
Last modified:2021-10-20
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:Structures of synthetic nanobody-SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interaction.
J.Biol.Chem., 297, 2021
7N0H
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BU of 7n0h by Molmil
CryoEM structure of SARS-CoV-2 spike protein (S-6P, 2-up) in complex with sybodies (Sb45)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Jiang, J, Huang, R, Margulies, D.
Deposit date:2021-05-25
Release date:2021-06-02
Last modified:2021-10-20
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Structures of synthetic nanobody-SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interaction.
J.Biol.Chem., 297, 2021
7N0R
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BU of 7n0r by Molmil
Structure of the SARS-CoV-2 N protein RNA-binding domain bound to single-domain antibody C2
Descriptor: Nucleoprotein, SULFATE ION, Single-domain antibody C2
Authors:Ye, Q, Corbett, K.D.
Deposit date:2021-05-25
Release date:2021-06-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structural Basis for SARS-CoV-2 Nucleocapsid Protein Recognition by Single-Domain Antibodies.
Front Immunol, 12, 2021
7O7Y
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BU of 7o7y by Molmil
Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution)
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ...
Authors:Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N.
Deposit date:2021-04-14
Release date:2021-06-02
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Science, 372, 2021
7O7Z
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BU of 7o7z by Molmil
Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot)
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ...
Authors:Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N.
Deposit date:2021-04-14
Release date:2021-06-02
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Science, 372, 2021
7O80
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BU of 7o80 by Molmil
Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ...
Authors:Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N.
Deposit date:2021-04-14
Release date:2021-06-02
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Science, 372, 2021
7O81
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BU of 7o81 by Molmil
Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ...
Authors:Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N.
Deposit date:2021-04-14
Release date:2021-06-02
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Science, 372, 2021
5SA4
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BU of 5sa4 by Molmil
PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NendoU in complex with Z239136710
Descriptor: N-(5-methyl-1H-pyrazol-3-yl)acetamide, Uridylate-specific endoribonuclease
Authors:Godoy, A.S, Douangamath, A, Nakamura, A.M, Dias, A, Krojer, T, Noske, G.D, Gawiljuk, V.O, Fernandes, R.S, Fairhead, M, Powell, A, Dunnet, L, Aimon, A, Fearon, D, Brandao-Neto, J, Skyner, R, von Delft, F, Oliva, G.
Deposit date:2021-05-19
Release date:2021-06-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.046 Å)
Cite:Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease.
Nucleic Acids Res., 2023
5SA5
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BU of 5sa5 by Molmil
PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NendoU in complex with Z1530301542
Descriptor: 4-ethyl-2-(1H-imidazol-5-yl)-1,3-thiazole, CITRIC ACID, Uridylate-specific endoribonuclease
Authors:Godoy, A.S, Douangamath, A, Nakamura, A.M, Dias, A, Krojer, T, Noske, G.D, Gawiljuk, V.O, Fernandes, R.S, Fairhead, M, Powell, A, Dunnet, L, Aimon, A, Fearon, D, Brandao-Neto, J, Skyner, R, von Delft, F, Oliva, G.
Deposit date:2021-05-19
Release date:2021-06-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease.
Nucleic Acids Res., 2023
5SA6
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BU of 5sa6 by Molmil
PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NendoU in complex with Z2856434783
Descriptor: N-benzyl-1-(4-fluorophenyl)methanamine, Uridylate-specific endoribonuclease
Authors:Godoy, A.S, Douangamath, A, Nakamura, A.M, Dias, A, Krojer, T, Noske, G.D, Gawiljuk, V.O, Fernandes, R.S, Fairhead, M, Powell, A, Dunnet, L, Aimon, A, Fearon, D, Brandao-Neto, J, Skyner, R, von Delft, F, Oliva, G.
Deposit date:2021-05-19
Release date:2021-06-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.517 Å)
Cite:Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease.
Nucleic Acids Res., 2023
5SA7
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BU of 5sa7 by Molmil
PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NendoU in complex with Z1673618163
Descriptor: 4-amino-N-(2-hydroxyethyl)-N-methylbenzene-1-sulfonamide, Uridylate-specific endoribonuclease
Authors:Godoy, A.S, Douangamath, A, Nakamura, A.M, Dias, A, Krojer, T, Noske, G.D, Gawiljuk, V.O, Fernandes, R.S, Fairhead, M, Powell, A, Dunnet, L, Aimon, A, Fearon, D, Brandao-Neto, J, Skyner, R, von Delft, F, Oliva, G.
Deposit date:2021-05-19
Release date:2021-06-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.222 Å)
Cite:Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease.
Nucleic Acids Res., 2023

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