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新型コロナウイルスの構造情報

このページの他言語版もあります: English简体中文繁體中文한국어
コロナウイルス
コロナウイルス, 2020. David S. Goodsell@RCSB PDB による原画を修正

最近、新型コロナウイルス感染症（Novel Coronavirus disease 2019: COVID-19）の拡大が世界中で深刻な問題となっています。早急にこの新型ウイルス（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）を理解し有効な薬を開発するため，関連するタンパク質の構造研究は既に始まっています。そして，解明された構造はPDBに登録されていっています。PDBjでは利用者の利便を図るため，新型コロナウイルス特集ページを作成しました。新たなエントリーが毎週水曜日の週次更新で公開されると、同時にこのページにも追加されます。

またこのウイルスのタンパク質に関する解説記事を以下の「今月の分子」ページに掲載しています。

「全エントリー」のタブでは，同じ著者によるグループ登録のエントリーも全て区別し，すべてのPDB IDを省略せず表示しています。 「代表構造」タブには最も分解能の高い代表構造のみを表示しており，アミノ酸配列が100%同じPDBエントリーはリガンドが異なるものも含め除外してあります。 「最新のエントリー」のタブは，今週公開された最も新しいエントリーです。

作成日: 2020-09-03 (最終更新日: more than 1 year ago)2022-09-02
全エントリー (5197)代表構造 (2266)最新のエントリー (44)
9CPY
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BU of 9cpy by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C11-0860 and CC12.3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C11-0860 Fab heavy chain, C11-0860 Fab light chain, ...
著者Feng, Z, Wilson, I.A.
登録日2024-07-18
公開日2025-06-25
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structures of CR3022-like antibodies
To Be Published
9P0F
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BU of 9p0f by Molmil
Crystal Structure of the C-terminal Cytoplasmic Domain of nsp4 from SARS-CoV-2
分子名称: Non-structural protein 4, SODIUM ION
著者Minasov, G, Shuvalova, L, Brunzelle, J.S, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID)
登録日2025-06-06
公開日2025-06-25
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal Structure of the C-terminal Cytoplasmic Domain of nsp4 from SARS-CoV-2
To Be Published
9CFE
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BU of 9cfe by Molmil
Cryo-EM Local Refinement of Antibody 19-77 in complex with prefusion SARS-CoV-2 Spike glycoprotein RBD
分子名称: Spike protein S1, heavy chain, light chain
著者Casner, R.G, Shapiro, L.
登録日2024-06-27
公開日2025-07-02
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献More SARS-CoV-2 antibodies
To Be Published
9CFF
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BU of 9cff by Molmil
Cryo-EM Refinement of Antibody 19-77 in complex with SARS-CoV-2 HK.3 RBD
分子名称: Spike protein S1, heavy chain, light chain
著者Casner, R.G, Shapiro, L.
登録日2024-06-27
公開日2025-07-02
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献More SARS-CoV-2 antibodies
To Be Published
9CFG
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BU of 9cfg by Molmil
Cryo-EM Refinement of Antibody 19-77 R71V in complex with SARS-CoV-2 HK.3 RBD
分子名称: Spike protein S1, heavy chain, light chain
著者Casner, R.G, Shapiro, L.
登録日2024-06-27
公開日2025-07-02
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献More SARS-CoV-2 antibodies
To Be Published
9CFH
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BU of 9cfh by Molmil
Cryo-EM Refinement of Antibody 19-77 R71V in complex with SARS-CoV-2 JD.1.1 RBD
分子名称: Spike protein S1, heavy chain, light chain
著者Casner, R.G, Shapiro, L.
登録日2024-06-27
公開日2025-07-02
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献More SARS-CoV-2 antibodies
To Be Published
9J8T
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BU of 9j8t by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with Mp-4L2
分子名称: 3C-like proteinase nsp5, TYR-DSG-DLE-DPN-DGN-ARG-DTH-DAS-DTR-DTH-ALO-DGN-DTY-CCJ-GLY-NH2
著者Shi, Y.S, Yang, J.Y, Wang, M.W.
登録日2024-08-21
公開日2025-07-02
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献De novo discovery of a non-covalent cell-penetrating bicyclic peptide inhibitor targeting SARS-CoV-2 main protease
To Be Published
9J8U
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BU of 9j8u by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with Mp-4D7
分子名称: 3C-like proteinase nsp5, DTY-VAL-THR-PHE-HIS-ALO-2TL-2TL-PRO-PHE-LEU-DPR-PRO-CCJ-GLY-NH2
著者Shi, Y.S, Yang, J.Y, Wang, M.W.
登録日2024-08-21
公開日2025-07-02
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献De novo discovery of a non-covalent cell-penetrating bicyclic pep-tide inhibitor targeting SARS-CoV-2 main protease
To Be Published
9P6P
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BU of 9p6p by Molmil
Crystal Structure of the SARS-CoV-2 2'-O-Methyltransferase with (m7GpppA)pUpU (Cap-0) and S-Adenosyl-L-homocysteine (SAH).
分子名称: 2'-O-methyltransferase, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
著者Minasov, G, Shuvalova, L, Maltseva, N, Kim, Y, Kiryukhina, O, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID)
登録日2025-06-19
公開日2025-07-02
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal Structure of the SARS-CoV-2 2'-O-Methyltransferase with (m7GpppA)pUpU (Cap-0) and S-Adenosyl-L-homocysteine (SAH).
To Be Published
9CJP
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BU of 9cjp by Molmil
X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Nirmatrelvir
分子名称: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 1,2-ETHANEDIOL, 3C-like proteinase nsp5, ...
著者Esler, M.A, Shi, K, Harris, R.S, Aihara, H.
登録日2024-07-07
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Nirmatrelvir
To Be Published
9CJQ
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BU of 9cjq by Molmil
X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Ensitrelvir
分子名称: 1,2-ETHANEDIOL, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, main protease
著者Esler, M.A, Shi, K, Harris, R.S, Aihara, H.
登録日2024-07-07
公開日2025-07-09
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Ensitrelvir
To Be Published
9CJR
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BU of 9cjr by Molmil
X-ray crystal structure of SARS-CoV-2 main protease double mutants in complex with Ensitrelvir
分子名称: 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, CHLORIDE ION, ...
著者Esler, M.A, Shi, K, Harris, R.S, Aihara, H.
登録日2024-07-07
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献X-ray crystal structure of SARS-CoV-2 main protease double mutants in complex with Ensitrelvir
To Be Published
9CJS
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BU of 9cjs by Molmil
X-ray crystal structure of SARS-CoV-2 main protease triple mutants in complex with Bofutrelvir
分子名称: 3C-like proteinase nsp5, ~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide
著者Esler, M.A, Shi, K, Harris, R.S, Aihara, H.
登録日2024-07-07
公開日2025-07-09
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献X-ray crystal structure of SARS-CoV-2 main protease triple mutants in complex with Bofutrelvir
To Be Published
9E9Q
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BU of 9e9q by Molmil
SARS-CoV-2 SL5 crystal structure native
分子名称: MAGNESIUM ION, RNA (101-MER)
著者Jones, C.P, Ferre-D'Amare, A.R.
登録日2024-11-08
公開日2025-07-09
実験手法X-RAY DIFFRACTION (3.33 Å)
主引用文献Crystallographic and cryoEM analyses reveal SARS-CoV-2 SL5 is a mobile T-shaped four-way junction with deep pockets.
Rna, 31, 2025
9MPW
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BU of 9mpw by Molmil
SARS-CoV2 Spike S2 Subunit in complex with M15 Antibody Fragment
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab M15 Heavy Chain, ...
著者Sapse, I.A, Bajic, G.
登録日2024-12-31
公開日2025-07-09
実験手法ELECTRON MICROSCOPY (3.37 Å)
主引用文献SARS-CoV2 Spike S2 Subunit in complex with M15 Antibody Fragment
To Be Published
9RCZ
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BU of 9rcz by Molmil
Structure of the N-terminal domain of non-structural protein 1 (Nsp1) from SARS-CoV-2
分子名称: ORF1a polyprotein
著者Lennartz, F, Weiss, M.S.
登録日2025-05-30
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Crystallographic fragment screening against SARS-CoV-2 Nsp1 using the F2X-Entry Screen and a newly developed fragment library.
To Be Published

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件を2025-07-09に公開中

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