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新型コロナウイルスの構造情報

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コロナウイルス
コロナウイルス, 2020. David S. Goodsell@RCSB PDB による原画を修正

最近、新型コロナウイルス感染症(Novel Coronavirus disease 2019: COVID-19)の拡大が世界中で深刻な問題となっています。早急にこの新型ウイルス(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)を理解し有効な薬を開発するため,関連するタンパク質の構造研究は既に始まっています。そして,解明された構造はPDBに登録されていっています。PDBjでは利用者の利便を図るため,新型コロナウイルス特集ページを作成しました。新たなエントリーが毎週水曜日の週次更新で公開されると、同時にこのページにも追加されます。

またこのウイルスのタンパク質に関する解説記事を以下の「今月の分子」ページに掲載しています。

「全エントリー」のタブでは,同じ著者によるグループ登録のエントリーも全て区別し,すべてのPDB IDを省略せず表示しています。 「代表構造」タブには最も分解能の高い代表構造のみを表示しており,アミノ酸配列が100%同じPDBエントリーはリガンドが異なるものも含め除外してあります。 「最新のエントリー」のタブは,今週公開された最も新しいエントリーです。


作成日: 2020-09-03 (最終更新日: more than 1 year ago)2022-09-02
8C0Y
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BU of 8c0y by Molmil
SARS-CoV2 Omicron BA.1 RBD in complex with CAB-A17 antibody
分子名称: CAB-A17 antibody (variable), Spike protein S2'
著者Das, H, Hallberg, B.M.
登録日2022-12-19
公開日2024-06-19
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.68 Å)
主引用文献Structural basis of broad SARS-CoV-2 cross-neutralization by affinity-matured public antibodies.
Cell Rep Med, 5, 2024
8QH0
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BU of 8qh0 by Molmil
Crystal structure of the SARS-CoV-2 RBD with the antibody Cv2.3194
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cv2.3194 Heavy chain, GLYCEROL, ...
著者Fernandez, I, Rey, F.A.
登録日2023-09-06
公開日2024-06-19
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献A broadly neutralizing antibody against SARS-CoV-2 Omicron variants
To Be Published
8QH1
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BU of 8qh1 by Molmil
Crystal structure of the SARS-CoV-2 RBD from the Omicron BA4 variant with the antibody Cv2.3194
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cv2.3194 heavy chain, IGK@ protein, ...
著者Fernandez, I, Rey, F.A.
登録日2023-09-06
公開日2024-06-19
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Pan-neutralizing antibody isolated from a COVID patient
To Be Published
8UKD
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SARS-CoV-2 Omicron-XBB.1.5 3-RBD down Spike Protein Trimer consensus (S-GSAS-Omicron-XBB.1.5)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Zhang, Q.E, Acharya, P.
登録日2023-10-12
公開日2024-06-19
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献SARS-CoV-2 Omicron-XBB.1.5 3-RBD down Spike Protein Trimer consensus (S-GSAS-Omicron-XBB.1.5)
To Be Published
8UKF
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BU of 8ukf by Molmil
SARS-CoV-2 Omicron-EG.5 3-RBD down Spike Protein Trimer consensus (S-GSAS-Omicron-EG.5)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Zhang, Q.E, Acharya, P.
登録日2023-10-12
公開日2024-06-19
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献SARS-CoV-2 Omicron-EG.5 3-RBD down Spike Protein Trimer consensus (S-GSAS-Omicron-EG.5)
To Be Published
8XBF
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BU of 8xbf by Molmil
Cryo-EM structure of SARS-CoV-2 S-BQ.1 in complex with antibody O5C2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, O5C2, heavy chain, ...
著者Hsu, H.F, Wu, M.H, Chang, Y.C, Hsu, S.T.D.
登録日2023-12-06
公開日2024-06-19
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Functional and structural investigation of a broadly neutralizing SARS-CoV-2 antibody.
JCI Insight, 9, 2024
8XXW
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BU of 8xxw by Molmil
Fab M2-7 complexed with SARS-Cov2 RBD and human ACE2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, M2-7-Heavy chain, M2-7-Light chain, ...
著者Liu, C, Xie, Y.
登録日2024-01-19
公開日2024-06-19
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献Mosaic RBD nanoparticle elicits immunodominant antibody responses across sarbecoviruses.
Cell Rep, 43, 2024
8YB5
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BU of 8yb5 by Molmil
SARS-CoV-2 DMV nsp3-4 pore complex (consensus-pore, C6 symmetry)
分子名称: Non-structural protein 4, Papain-like protease nsp3
著者Huang, Y.X, Zhong, L.J, Zhang, W.X, Ni, T.
登録日2024-02-11
公開日2024-06-19
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Molecular Architecture of Coronavirus Double Membrane Vesicle Pore Complex
To Be Published
9EOW
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BU of 9eow by Molmil
The 5-terminal stem-loop RNA element of SARS-CoV-2 features highly dynamic structural elements that are sensitive to differences in cellular pH
分子名称: RNA (29-MER)
著者Wacker, A, Schwalbe, H.
登録日2024-03-15
公開日2024-06-19
最終更新日2024-07-31
実験手法SOLUTION NMR
主引用文献The 5'-terminal stem-loop RNA element of SARS-CoV-2 features highly dynamic structural elements that are sensitive to differences in cellular pH.
Nucleic Acids Res., 52, 2024
8T7Y
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BU of 8t7y by Molmil
Structure of SARS CoV-2 main protease in complex with Chymostatin.
分子名称: 3C-like proteinase nsp5, Chymostatin A (bound form)
著者Terzyan, S, Yarla, N, Rao, C.V, Mooers, B.
登録日2023-06-21
公開日2024-06-26
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structure of SARS CoV-2 main protease in complex with Chymostatin.
to be published
8WHZ
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BU of 8whz by Molmil
BA.2.86 RBD in complex with hACE2 (local refinement)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Processed angiotensin-converting enzyme 2, ...
著者Yue, C, Liu, P.
登録日2023-09-23
公開日2024-06-26
最終更新日2024-08-14
実験手法ELECTRON MICROSCOPY (3.93 Å)
主引用文献Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity.
Natl Sci Rev, 11, 2024
8X4Z
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BU of 8x4z by Molmil
BA.2.86 Spike Trimer with ins483V mutation (3 RBD down)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Yue, C, Liu, P.
登録日2023-11-16
公開日2024-06-26
最終更新日2024-08-14
実験手法ELECTRON MICROSCOPY (3.49 Å)
主引用文献Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity.
Natl Sci Rev, 11, 2024
8OYT
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BU of 8oyt by Molmil
Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '3 up' RBD conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, H6 nanobody, ...
著者Weckener, M, Naismith, J.H, Owens, R.J.
登録日2023-05-05
公開日2024-07-03
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2.
Open Biology, 14, 2024
8WHU
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BU of 8whu by Molmil
Spike Trimer of BA.2.86 in complex with two hACE2s
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Processed angiotensin-converting enzyme 2, ...
著者Yue, C, Liu, P.
登録日2023-09-23
公開日2024-07-03
最終更新日2024-08-14
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity.
Natl Sci Rev, 11, 2024
8WHV
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BU of 8whv by Molmil
Spike Trimer of BA.2.86 with three RBDs down
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Yue, C, Liu, P.
登録日2023-09-23
公開日2024-07-03
最終更新日2024-08-14
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity.
Natl Sci Rev, 11, 2024
8WP8
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BU of 8wp8 by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 RBD in complex with human ACE2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
著者Li, L.J, Gu, Y.H, Qi, J.X, Gao, G.F.
登録日2023-10-09
公開日2024-07-03
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 RBD in complex with human ACE2
To Be Published
8X5Q
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BU of 8x5q by Molmil
SARS-CoV-2 BA.2.75 Spike with K356T mutation (3 RBD down)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Yue, C, Liu, P.
登録日2023-11-17
公開日2024-07-03
最終更新日2024-08-14
実験手法ELECTRON MICROSCOPY (3.47 Å)
主引用文献Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity.
Natl Sci Rev, 11, 2024
8XLV
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BU of 8xlv by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 spike protein(6P), 1-RBD-up state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
登録日2023-12-26
公開日2024-07-03
最終更新日2024-08-07
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献Spike structures, receptor binding, and immune escape of recently circulating SARS-CoV-2 Omicron BA.2.86, JN.1, EG.5, EG.5.1, and HV.1 sub-variants.
Structure, 2024
8XM5
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BU of 8xm5 by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron EG.5 spike protein(6P), RBD-closed state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
登録日2023-12-27
公開日2024-07-03
最終更新日2024-08-07
実験手法ELECTRON MICROSCOPY (2.61 Å)
主引用文献Spike structures, receptor binding, and immune escape of recently circulating SARS-CoV-2 Omicron BA.2.86, JN.1, EG.5, EG.5.1, and HV.1 sub-variants.
Structure, 2024
8XMG
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BU of 8xmg by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron HV.1 spike protein(6P), RBD-closed state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
登録日2023-12-27
公開日2024-07-03
最終更新日2024-08-07
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Spike structures, receptor binding, and immune escape of recently circulating SARS-CoV-2 Omicron BA.2.86, JN.1, EG.5, EG.5.1, and HV.1 sub-variants.
Structure, 2024
8XMT
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BU of 8xmt by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron EG.5.1 spike protein(6P), RBD-closed state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
登録日2023-12-28
公開日2024-07-03
最終更新日2024-08-07
実験手法ELECTRON MICROSCOPY (3.31 Å)
主引用文献Spike structures, receptor binding, and immune escape of recently circulating SARS-CoV-2 Omicron BA.2.86, JN.1, EG.5, EG.5.1, and HV.1 sub-variants.
Structure, 2024
8XN2
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BU of 8xn2 by Molmil
SARS-CoV-2 Omicron EG.5.1 RBD in complex with human ACE2 (local refined from the spike protein)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ...
著者Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
登録日2023-12-28
公開日2024-07-03
最終更新日2024-08-07
実験手法ELECTRON MICROSCOPY (2.79 Å)
主引用文献Spike structures, receptor binding, and immune escape of recently circulating SARS-CoV-2 Omicron BA.2.86, JN.1, EG.5, EG.5.1, and HV.1 sub-variants.
Structure, 2024
8XN3
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BU of 8xn3 by Molmil
SARS-CoV-2 Omicron HV.1 RBD in complex with human ACE2 (local refinement from the spike protein)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ...
著者Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
登録日2023-12-28
公開日2024-07-03
最終更新日2024-08-07
実験手法ELECTRON MICROSCOPY (2.64 Å)
主引用文献Spike structures, receptor binding, and immune escape of recently circulating SARS-CoV-2 Omicron BA.2.86, JN.1, EG.5, EG.5.1, and HV.1 sub-variants.
Structure, 2024
8XN5
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BU of 8xn5 by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron EG.5.1 spike protein(6P) in complex with human ACE2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ...
著者Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
登録日2023-12-29
公開日2024-07-03
最終更新日2024-08-07
実験手法ELECTRON MICROSCOPY (2.87 Å)
主引用文献Spike structures, receptor binding, and immune escape of recently circulating SARS-CoV-2 Omicron BA.2.86, JN.1, EG.5, EG.5.1, and HV.1 sub-variants.
Structure, 2024
8XNF
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BU of 8xnf by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 spike protein(6P) in complex with human ACE2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
著者Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
登録日2023-12-29
公開日2024-07-03
最終更新日2024-08-07
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Spike structures, receptor binding, and immune escape of recently circulating SARS-CoV-2 Omicron BA.2.86, JN.1, EG.5, EG.5.1, and HV.1 sub-variants.
Structure, 2024

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件を2024-08-14に公開中

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