新型コロナウイルスの構造情報

コロナウイルス, 2020. David S. Goodsell@RCSB PDB による原画を修正

最近、新型コロナウイルス感染症（Novel Coronavirus disease 2019: COVID-19）の拡大が世界中で深刻な問題となっています。早急にこの新型ウイルス（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）を理解し有効な薬を開発するため，関連するタンパク質の構造研究は既に始まっています。そして，解明された構造はPDBに登録されていっています。PDBjでは利用者の利便を図るため，新型コロナウイルス特集ページを作成しました。新たなエントリーが毎週水曜日の週次更新で公開されると、同時にこのページにも追加されます。

またこのウイルスのタンパク質に関する解説記事を以下の「今月の分子」ページに掲載しています。

「全エントリー」のタブでは，同じ著者によるグループ登録のエントリーも全て区別し，すべてのPDB IDを省略せず表示しています。 「代表構造」タブには最も分解能の高い代表構造のみを表示しており，アミノ酸配列が100%同じPDBエントリーはリガンドが異なるものも含め除外してあります。 「最新のエントリー」のタブは，今週公開された最も新しいエントリーです。

作成日: 2020-09-03 (最終更新日: more than 1 year ago)

全エントリー (4406)代表構造 (1944)最新のエントリー (19)

7GNI

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with EDG-MED-b1ef7fe3-1 (Mpro-P2660)
分子名称:	2-[(3'S)-6-chloro-1'-(6-chloroisoquinolin-4-yl)-1,2'-dioxo-1H-spiro[isoquinoline-4,3'-pyrrolidin]-2(3H)-yl]-N-methylacetamide, 3C-like proteinase, CHLORIDE ION, ...
著者	Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
登録日	2023-08-11
公開日	2023-11-08
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.644 Å)
主引用文献	Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

7GNJ

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with EDJ-MED-976a33d5-1 (Mpro-P2724)
分子名称:	1-[(3'S)-6-chloro-1'-(isoquinolin-4-yl)-1,2'-dioxo-1H-spiro[isoquinoline-4,3'-pyrrolidin]-2(3H)-yl]-N-methylcyclopropane-1-carboxamide, 3C-like proteinase, CHLORIDE ION, ...
著者	Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
登録日	2023-08-11
公開日	2023-11-08
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.45 Å)
主引用文献	Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

7GNK

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with ALP-POS-ecbed2ba-12 (Mpro-P2730)
分子名称:	2-[(3'S)-6-chloro-1'-(isoquinolin-4-yl)-2'-oxo-1H-spiro[isoquinoline-4,3'-pyrrolidin]-2(3H)-yl]-N-(cyclopropylmethyl)acetamide, 3C-like proteinase, CHLORIDE ION, ...
著者	Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
登録日	2023-08-11
公開日	2023-11-08
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.72 Å)
主引用文献	Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

7GNL

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with NIR-WEI-dcc3321b-1 (Mpro-P2757)
分子名称:	(4S)-6-chloro-2-{2-[4-(4-ethylpiperazin-1-yl)anilino]-2-oxoethyl}-N-(isoquinolin-4-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide, 3C-like proteinase, CHLORIDE ION, ...
著者	Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
登録日	2023-08-11
公開日	2023-11-08
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.681 Å)
主引用文献	Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

7GNM

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with NIR-WEI-dcc3321b-2 (Mpro-P2761)
分子名称:	(4S)-6-chloro-N-(isoquinolin-4-yl)-2-{2-[3-(morpholin-4-yl)anilino]-2-oxoethyl}-1,2,3,4-tetrahydroisoquinoline-4-carboxamide, 3C-like proteinase, CHLORIDE ION, ...
著者	Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
登録日	2023-08-11
公開日	2023-11-08
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

7GNN

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with NIR-WEI-dcc3321b-3 (Mpro-P2775)
分子名称:	(4S)-2-{2-[(1,3-benzothiazol-5-yl)amino]-2-oxoethyl}-6-chloro-N-(isoquinolin-4-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide, 3C-like proteinase, CHLORIDE ION, ...
著者	Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
登録日	2023-08-11
公開日	2023-11-08
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.81 Å)
主引用文献	Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

7GNO

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with NIR-WEI-dcc3321b-4 (Mpro-P2838)
分子名称:	(4S)-6-chloro-N-(isoquinolin-4-yl)-2-(2-{[(1S)-1-(4-nitrophenyl)ethyl]amino}-2-oxoethyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide, 3C-like proteinase, CHLORIDE ION, ...
著者	Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
登録日	2023-08-11
公開日	2023-11-08
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.661 Å)
主引用文献	Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

7GNP

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with NIR-WEI-dcc3321b-5 (Mpro-P2889)
分子名称:	(4S)-6-chloro-2-(2-{[(1r,3R,5R,7S)-3-hydroxyadamantan-1-yl]amino}-2-oxoethyl)-N-(isoquinolin-4-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide, 3C-like proteinase, CHLORIDE ION, ...
著者	Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
登録日	2023-08-11
公開日	2023-11-08
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.55 Å)
主引用文献	Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

7GNQ

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with NIR-WEI-dcc3321b-6 (Mpro-P2916)
分子名称:	(4S)-2-[2-(4-acetamidoanilino)-2-oxoethyl]-6-chloro-N-(isoquinolin-4-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide, 3C-like proteinase, CHLORIDE ION, ...
著者	Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
登録日	2023-08-11
公開日	2023-11-08
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.531 Å)
主引用文献	Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

7GNR

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with MAT-POS-e48723dc-2 (Mpro-P3038)
分子名称:	1-[(3'S)-6-chloro-1'-(isoquinolin-4-yl)-1,2'-dioxo-1H-spiro[isoquinoline-4,3'-pyrrolidin]-2(3H)-yl]-N-methylcyclopropane-1-carboxamide, 3C-like proteinase, CHLORIDE ION, ...
著者	Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
登録日	2023-08-11
公開日	2023-11-08
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.819 Å)
主引用文献	Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

7GNS

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with MAT-POS-50a80394-1 (Mpro-P3050)
分子名称:	1-{[(3'S,4'R)-6-chloro-1'-(isoquinolin-4-yl)-4'-methyl-2'-oxo-1H-spiro[isoquinoline-4,3'-pyrrolidine]-2(3H)-sulfonyl]methyl}cyclopropane-1-carbonitrile, 3C-like proteinase, CHLORIDE ION, ...
著者	Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
登録日	2023-08-11
公開日	2023-11-08
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.617 Å)
主引用文献	Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

7GNT

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with MAT-POS-50a80394-2 (Mpro-P3054)
分子名称:	1-{[(3'S,4'R)-6-chloro-4'-ethyl-1'-(isoquinolin-4-yl)-2'-oxo-1H-spiro[isoquinoline-4,3'-pyrrolidine]-2(3H)-sulfonyl]methyl}cyclopropane-1-carbonitrile, 3C-like proteinase, CHLORIDE ION, ...
著者	Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
登録日	2023-08-11
公開日	2023-11-08
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.561 Å)
主引用文献	Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

7GNU

Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with ALP-POS-133e7cd9-2 (Mpro-P3074)
分子名称:	1-{[(3'S)-6-chloro-1'-(isoquinolin-4-yl)-2'-oxo-1H-spiro[isoquinoline-4,3'-piperidine]-2(3H)-sulfonyl]methyl}cyclopropane-1-carbonitrile, 3C-like proteinase, CHLORIDE ION, ...
著者	Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
登録日	2023-08-11
公開日	2023-11-08
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.48 Å)
主引用文献	Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science, 382, 2023

7XQS

The structure of FLA-K*00701/KP-CoV-9
分子名称:	Beta-2-microglobulin, MHC class I antigen alpha chain, peptide from Spike glycoprotein
著者	Qiao, P.W, Yue, C, Peng, W.Y, Liu, K.F, Huo, S.T, Zhang, D, Chai, Y, Qi, J.X, Sun, Z.Y, Gao, G.F, Liu, W.J, Wu, G.Z.
登録日	2022-05-08
公開日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.69 Å)
主引用文献	Analysis of the characteristics of feline major histocompatibility complex class I molecules cross-presenting coronavirus peptides To Be Published

8BFO

Structure of the apo form of Mpro from SARS-CoV-2
分子名称:	3C-like proteinase nsp5
著者	Medrano, F.J, Romero, A.
登録日	2022-10-26
公開日	2023-11-08
実験手法	X-RAY DIFFRACTION (1.99 Å)
主引用文献	Peptidyl Nitroalkenes Inhibit SARS-CoV-2 Main Protease and Block Virus Replication To Be Published

8BFQ

Structure of the apo form of Mpro from SARS-CoV-2
分子名称:	3C-like proteinase nsp5
著者	Medrano, F.J, Romero, A.
登録日	2022-10-26
公開日	2023-11-08
実験手法	X-RAY DIFFRACTION (1.863 Å)
主引用文献	Peptidyl Nitroalkenes Inhibit SARS-CoV-2 Main Protease and Block Virus Replication To Be Published

8BG2

Crystal structure of the SARS-CoV-2 S RBD in complex with pT1580 scFV
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, pT1375 single-chain Fv
著者	Hansen, G, Ssebyatika, G.L, Krey, T.
登録日	2022-10-27
公開日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

8BG3

Crystal structure of the SARS-CoV-2 S RBD in complex with pT1610 scFV
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, pT1610 single-chain Fv
著者	Hansen, G, Ssebyatika, G.L, Krey, T.
登録日	2022-10-27
公開日	2023-11-08
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

8BG4

Crystal structure of the SARS-CoV-2 S RBD in complex with pT1611 scFV
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, pT1611 single-chain Fv
著者	Hansen, G, Ssebyatika, G.L, Krey, T.
登録日	2022-10-27
公開日	2023-11-08
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

8BG5

Crystal structure of the SARS-CoV-2 S RBD in complex with pT1631 scFV
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, pT1631 single-chain Fv
著者	Hansen, G, Ssebyatika, G.L, Krey, T.
登録日	2022-10-27
公開日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

8BG6

SARS-CoV-2 S protein in complex with pT1644 Fab
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, pT1644 Fab heavy chain, ...
著者	Stroeh, L, Hansen, G, Vollmer, B, Krey, T, Benecke, T, Gruenewald, K.
登録日	2022-10-27
公開日	2023-11-08
実験手法	ELECTRON MICROSCOPY (4.11 Å)
主引用文献	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

8BG8

SARS-CoV-2 S protein in complex with pT1696 Fab
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, pT1696 Fab heavy chain, ...
著者	Hansen, G, Benecke, T, Vollmer, B, Gruenewald, K, Krey, T.
登録日	2022-10-27
公開日	2023-11-08
実験手法	ELECTRON MICROSCOPY (3.64 Å)
主引用文献	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

8BGA

Structure of Mpro in complex with FGA146
分子名称:	3C-like proteinase nsp5, 4-methoxy-~{N}-[(2~{S})-4-methyl-1-[[(2~{S})-4-nitro-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]butan-2-yl]amino]-1-oxidanylidene-pentan-2-yl]-1~{H}-indole-2-carboxamide
著者	Medrano, F.J, Romero, A.
登録日	2022-10-27
公開日	2023-11-08
最終更新日	2024-03-27
実験手法	X-RAY DIFFRACTION (1.982 Å)
主引用文献	Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2. Commun Chem, 7, 2024

8BGD

Structure of Mpro from SARS-CoV-2 in complex with FGA147
分子名称:	(phenylmethyl) ~{N}-[(2~{S})-4-methyl-1-[[(2~{S})-4-nitro-1-[(3~{R})-2-oxidanylidenepyrrolidin-3-yl]butan-2-yl]amino]-1-oxidanylidene-pentan-2-yl]carbamate, 3C-like proteinase nsp5
著者	Medrano, F.J, Romero, A.
登録日	2022-10-27
公開日	2023-11-08
実験手法	X-RAY DIFFRACTION (1.621 Å)
主引用文献	Peptidyl Nitroalkenes Inhibit SARS-CoV-2 Main Protease and Block Virus Replication To Be Published

8HES

Crystal structure of SARS-CoV-2 RBD and NIV-10 complex
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, NIV-10 Fab H-chain, NIV-10 Fab L-chain, ...
著者	Moriyama, S, Anraku, Y, Taminishi, S, Adachi, Y, Kuroda, D, Higuchi, Y, Kotaki, R, Tonouchi, K, Yumoto, K, Suzuki, T, Kita, S, Someya, T, Fukuhara, H, Kuroda, Y, Yamamoto, T, Onodera, T, Fukushi, S, Maeda, K, Nakamura-Uchiyama, F, Hashiguchi, T, Hoshino, A, Maenaka, K, Takahashi, Y.
登録日	2022-11-08
公開日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants. Nat Commun, 14, 2023

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全ヒット件数:	4406
表示件数:	25
表示順	公開日の古い順