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Yorodumi- PDB-7lek: Crystal structure of the second bromodomain (BD2) of human BRDT b... -
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-Basic information
Entry | Database: PDB / ID: 7lek | ||||||
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Title | Crystal structure of the second bromodomain (BD2) of human BRDT bound to ERK5-IN-1 | ||||||
Components | Bromodomain testis-specific protein | ||||||
Keywords | GENE REGULATION / BRDT / BET / PLK1 / testis specific / Bromodomain | ||||||
Function / homology | Function and homology information sperm DNA condensation / male meiotic nuclear division / male meiosis I / regulation of RNA splicing / histone reader activity / RNA splicing / lysine-acetylated histone binding / mRNA processing / histone binding / transcription coactivator activity ...sperm DNA condensation / male meiotic nuclear division / male meiosis I / regulation of RNA splicing / histone reader activity / RNA splicing / lysine-acetylated histone binding / mRNA processing / histone binding / transcription coactivator activity / chromatin remodeling / regulation of DNA-templated transcription / positive regulation of gene expression / nucleus Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 2.75 Å | ||||||
Authors | Chan, A. / Karim, M.R. / Schonbrunn, E. | ||||||
Citation | Journal: J.Med.Chem. / Year: 2021 Title: Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. Authors: Karim, R.M. / Bikowitz, M.J. / Chan, A. / Zhu, J.Y. / Grassie, D. / Becker, A. / Berndt, N. / Gunawan, S. / Lawrence, N.J. / Schonbrunn, E. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7lek.cif.gz | 210.7 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7lek.ent.gz | 169.3 KB | Display | PDB format |
PDBx/mmJSON format | 7lek.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/le/7lek ftp://data.pdbj.org/pub/pdb/validation_reports/le/7lek | HTTPS FTP |
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-Related structure data
Related structure data | 5v67C 5vboC 5vbpC 5vbqC 5vbrC 7bjyC 7k6gC 7k6hC 7ko0C 7l6dC 7l72C 7l73C 7l9gC 7l9jC 7l9kC 7l9lC 7lahC 7laiC 7lajC 7lakC 7lauC 7layC 7lazC 7lb4C 7lbtC 7lejC 7lelC 7lemC 3vbqS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
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-Assembly
Deposited unit |
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Unit cell |
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Components on special symmetry positions |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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