Entry Database : PDB / ID : 6y1j Structure visualization Downloads & linksTitle 14-3-3 sigma in complex with IkappaBalpha pS63 peptide Components14-3-3 protein sigma NF-kappa-B inhibitor alpha DetailsKeywords PEPTIDE BINDING PROTEIN / 14-3-3 sigma / IkBa / Nf-kBFunction / homology Function and homology informationFunction Domain/homology Component
I-kappaB/NF-kappaB complex / cytoplasmic sequestering of NF-kappaB / negative regulation of myeloid cell differentiation / nucleotide-binding oligomerization domain containing 1 signaling pathway / IkBA variant leads to EDA-ID / molecular sequestering activity / RIP-mediated NFkB activation via ZBP1 / SUMOylation of immune response proteins / nucleotide-binding oligomerization domain containing 2 signaling pathway / transcription regulator inhibitor activity ... I-kappaB/NF-kappaB complex / cytoplasmic sequestering of NF-kappaB / negative regulation of myeloid cell differentiation / nucleotide-binding oligomerization domain containing 1 signaling pathway / IkBA variant leads to EDA-ID / molecular sequestering activity / RIP-mediated NFkB activation via ZBP1 / SUMOylation of immune response proteins / nucleotide-binding oligomerization domain containing 2 signaling pathway / transcription regulator inhibitor activity / cellular response to cold / interleukin-1-mediated signaling pathway / toll-like receptor 4 signaling pathway / nuclear localization sequence binding / negative regulation of NF-kappaB transcription factor activity / regulation of epidermal cell division / protein kinase C inhibitor activity / negative regulation of Notch signaling pathway / response to exogenous dsRNA / positive regulation of epidermal cell differentiation / keratinocyte development / keratinization / non-canonical NF-kappaB signal transduction / TRAF6 mediated NF-kB activation / response to muramyl dipeptide / negative regulation of macrophage derived foam cell differentiation / negative regulation of lipid storage / Regulation of localization of FOXO transcription factors / keratinocyte proliferation / NF-kappaB binding / phosphoserine residue binding / positive regulation of cholesterol efflux / Activation of BAD and translocation to mitochondria / negative regulation of keratinocyte proliferation / positive regulation of transcription initiation by RNA polymerase II / canonical NF-kappaB signal transduction / establishment of skin barrier / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / negative regulation of stem cell proliferation / negative regulation of canonical NF-kappaB signal transduction / RHO GTPases activate PKNs / lipopolysaccharide-mediated signaling pathway / Notch signaling pathway / protein kinase A signaling / tumor necrosis factor-mediated signaling pathway / protein sequestering activity / response to muscle stretch / positive regulation of protein metabolic process / negative regulation of innate immune response / protein export from nucleus / NF-kB is activated and signals survival / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / positive regulation of protein export from nucleus / release of cytochrome c from mitochondria / stem cell proliferation / Translocation of SLC2A4 (GLUT4) to the plasma membrane / TP53 Regulates Metabolic Genes / Activation of NF-kappaB in B cells / B cell receptor signaling pathway / negative regulation of protein kinase activity / TAK1-dependent IKK and NF-kappa-B activation / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / CLEC7A (Dectin-1) signaling / FCERI mediated NF-kB activation / Interleukin-1 signaling / positive regulation of inflammatory response / protein import into nucleus / SARS-CoV-1 activates/modulates innate immune responses / intrinsic apoptotic signaling pathway in response to DNA damage / Downstream TCR signaling / cellular response to tumor necrosis factor / regulation of cell population proliferation / positive regulation of cell growth / Ub-specific processing proteases / regulation of cell cycle / cadherin binding / apoptotic process / ubiquitin protein ligase binding / protein kinase binding / enzyme binding / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular exosome / nucleoplasm / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function Ankyrin repeats (many copies) / 14-3-3 protein sigma / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein ... Ankyrin repeats (many copies) / 14-3-3 protein sigma / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.127 Å DetailsAuthors Wolter, M. / Ottmann, C. Funding support Netherlands, 1items Details Hide detailsOrganization Grant number Country European Commission Netherlands
CitationJournal : Acs Omega / Year : 2020Title : Interaction of an I kappa B alpha Peptide with 14-3-3.Authors : Wolter, M. / Santo, D.L. / Herman, P. / Ballone, A. / Centorrino, F. / Obsil, T. / Ottmann, C. History Deposition Feb 12, 2020 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 4, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Apr 1, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title Revision 1.2 Jan 24, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_conn_type Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr2_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_ptnr1_label_alt_id / _struct_conn.pdbx_ptnr2_label_alt_id / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry / _struct_conn_type.id
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