- PDB-6qiu: Crystal structure of 14-3-3 sigma in complex with Ataxin-1 Ser776... -
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Basic information
Entry
Database: PDB / ID: 6qiu
Title
Crystal structure of 14-3-3 sigma in complex with Ataxin-1 Ser776 phosphopeptide
Components
14-3-3 protein sigma
Ataxin-1 phosphopeptide
Keywords
PROTEIN BINDING / phosphoprotein binding anti-aggregation
Function / homology
Function and homology information
poly(G) binding / nuclear inclusion body / poly(U) RNA binding / nuclear export / regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / keratinization / social behavior ...poly(G) binding / nuclear inclusion body / poly(U) RNA binding / nuclear export / regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / keratinization / social behavior / Regulation of localization of FOXO transcription factors / keratinocyte proliferation / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / negative regulation of keratinocyte proliferation / establishment of skin barrier / RNA processing / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / negative regulation of stem cell proliferation / RHO GTPases activate PKNs / protein kinase A signaling / protein sequestering activity / negative regulation of innate immune response / protein export from nucleus / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / positive regulation of protein export from nucleus / release of cytochrome c from mitochondria / learning / stem cell proliferation / Translocation of SLC2A4 (GLUT4) to the plasma membrane / TP53 Regulates Metabolic Genes / negative regulation of protein kinase activity / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / brain development / memory / nuclear matrix / : / intrinsic apoptotic signaling pathway in response to DNA damage / nervous system development / positive regulation of cell growth / regulation of cell cycle / cadherin binding / negative regulation of DNA-templated transcription / nucleolus / protein kinase binding / negative regulation of transcription by RNA polymerase II / signal transduction / DNA binding / extracellular space / extracellular exosome / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function
Ataxin-1, N-terminal / ATAXIN1-like / Ataxin-1 like family / Ataxin, AXH domain / Ataxin, AXH domain superfamily / Ataxin-1 and HBP1 module (AXH) / AXH domain profile. / domain in Ataxins and HMG containing proteins / 14-3-3 protein sigma / 14-3-3 proteins signature 2. ...Ataxin-1, N-terminal / ATAXIN1-like / Ataxin-1 like family / Ataxin, AXH domain / Ataxin, AXH domain superfamily / Ataxin-1 and HBP1 module (AXH) / AXH domain profile. / domain in Ataxins and HMG containing proteins / 14-3-3 protein sigma / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein Similarity search - Domain/homology
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