- PDB-4qli: A novel phospho-switch in the linker region of the snail zinc fin... -
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Basic information
Entry
Database: PDB / ID: 4qli
Title
A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
Components
14-3-3 protein sigma
Zinc finger protein SNAI1
Keywords
SIGNALING PROTEIN / 14-3-3 / adapter protein / protein-protein interaction
Function / homology
Function and homology information
negative regulation of cell differentiation involved in embryonic placenta development / cartilage morphogenesis / left/right pattern formation / negative regulation of vitamin D biosynthetic process / Regulation of CDH11 gene transcription / epithelial cell migration / epithelial to mesenchymal transition involved in endocardial cushion formation / trophoblast giant cell differentiation / Epithelial-Mesenchymal Transition (EMT) during gastrulation / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ...negative regulation of cell differentiation involved in embryonic placenta development / cartilage morphogenesis / left/right pattern formation / negative regulation of vitamin D biosynthetic process / Regulation of CDH11 gene transcription / epithelial cell migration / epithelial to mesenchymal transition involved in endocardial cushion formation / trophoblast giant cell differentiation / Epithelial-Mesenchymal Transition (EMT) during gastrulation / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / aortic valve morphogenesis / regulation of bicellular tight junction assembly / hair follicle morphogenesis / roof of mouth development / regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / keratinization / E-box binding / negative regulation of DNA damage response, signal transduction by p53 class mediator / Regulation of localization of FOXO transcription factors / mesoderm formation / keratinocyte proliferation / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / negative regulation of keratinocyte proliferation / epithelial to mesenchymal transition / canonical Wnt signaling pathway / establishment of skin barrier / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / pericentric heterochromatin / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / heterochromatin organization / positive regulation of epithelial to mesenchymal transition / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / negative regulation of stem cell proliferation / RHO GTPases activate PKNs / Notch signaling pathway / protein kinase A signaling / protein sequestering activity / negative regulation of innate immune response / protein export from nucleus / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / positive regulation of protein export from nucleus / release of cytochrome c from mitochondria / stem cell proliferation / Regulation of PTEN gene transcription / Translocation of SLC2A4 (GLUT4) to the plasma membrane / TP53 Regulates Metabolic Genes / RNA polymerase II transcription regulatory region sequence-specific DNA binding / negative regulation of protein kinase activity / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / fibrillar center / kinase binding / DNA-binding transcription repressor activity, RNA polymerase II-specific / osteoblast differentiation / intrinsic apoptotic signaling pathway in response to DNA damage / sequence-specific double-stranded DNA binding / positive regulation of cell growth / regulation of cell cycle / positive regulation of cell migration / cadherin binding / RNA polymerase II cis-regulatory region sequence-specific DNA binding / intracellular membrane-bounded organelle / regulation of DNA-templated transcription / protein kinase binding / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / signal transduction / extracellular space / extracellular exosome / nucleoplasm / identical protein binding / nucleus / metal ion binding / cytoplasm / cytosol Similarity search - Function
Method to determine structure: MOLECULAR REPLACEMENT / Resolution: 1.45→45.44 Å / Cor.coef. Fo:Fc: 0.967 / Cor.coef. Fo:Fc free: 0.95 / WRfactor Rfree: 0.2122 / WRfactor Rwork: 0.181 / FOM work R set: 0.8917 / SU B: 0.864 / SU ML: 0.035 / SU R Cruickshank DPI: 0.0593 / SU Rfree: 0.0642 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R: 0.059 / ESU R Free: 0.064 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.203
2553
5 %
RANDOM
Rwork
0.1694
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-
-
obs
0.1711
51037
99.42 %
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all
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51053
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-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK
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