登録情報 | データベース: PDB / ID: 6mek |
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タイトル | Crystal structure of Hepatitis C virus envelope glycoprotein E2 core in complex with human antibodies HEPC3 and HEPC46 |
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要素 | - E2 GLYCOPROTEIN
- HEPC3 Heavy Chain
- HEPC3 Light Chain
- HEPC46 Heavy Chain
- HEPC46 Light Chain
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キーワード | IMMUNE SYSTEM / HCV glycoprotein / broadly neutralizing antibodies |
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機能・相同性 | 機能・相同性情報
host cell mitochondrial membrane / host cell lipid droplet / transformation of host cell by virus / serine-type peptidase activity / lipid droplet / nucleoside-triphosphate phosphatase / viral nucleocapsid / clathrin-dependent endocytosis of virus by host cell / membrane => GO:0016020 / RNA helicase activity ...host cell mitochondrial membrane / host cell lipid droplet / transformation of host cell by virus / serine-type peptidase activity / lipid droplet / nucleoside-triphosphate phosphatase / viral nucleocapsid / clathrin-dependent endocytosis of virus by host cell / membrane => GO:0016020 / RNA helicase activity / host cell endoplasmic reticulum membrane / RNA helicase / cysteine-type endopeptidase activity / fusion of virus membrane with host endosome membrane / viral envelope / host cell nucleus / virion attachment to host cell / virion membrane / structural molecule activity / ATP binding / cytoplasm類似検索 - 分子機能 Hepatitis C virus non-structural protein NS2, C-terminal domain / Hepatitis C virus non-structural protein NS2, N-terminal domain / Hepatitis C virus non-structural protein NS2 / Hepatitis C virus, Core protein, N-terminal / Hepatitis C virus capsid protein / Hepatitis C virus, Non-structural protein NS2 / Hepacivirus nonstructural protein 2 (NS2) protease domain profile. / Hepatitis C virus, Core protein, C-terminal / Hepatitis C virus core protein / Hepatitis C virus, Non-structural protein E2/NS1 ...Hepatitis C virus non-structural protein NS2, C-terminal domain / Hepatitis C virus non-structural protein NS2, N-terminal domain / Hepatitis C virus non-structural protein NS2 / Hepatitis C virus, Core protein, N-terminal / Hepatitis C virus capsid protein / Hepatitis C virus, Non-structural protein NS2 / Hepacivirus nonstructural protein 2 (NS2) protease domain profile. / Hepatitis C virus, Core protein, C-terminal / Hepatitis C virus core protein / Hepatitis C virus, Non-structural protein E2/NS1 / Hepatitis C virus non-structural protein E2/NS1 / Hepatitis C virus, Envelope glycoprotein E1 / Hepatitis C virus envelope glycoprotein E1 / Hepatitis C virus, NS3 protease, Peptidase S29 / Hepatitis C virus NS3 protease / Hepacivirus/Pegivirus NS3 protease domain profile. / DEAD box, Flavivirus / Flavivirus DEAD domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / Immunoglobulins / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Immunoglobulin-like / Sandwich / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Hepacivirus C (ウイルス) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 3.1 Å |
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データ登録者 | Flyak, A.I. / Bjorkman, P.J. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | AI127469 | 米国 |
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引用 | ジャーナル: Cell Host Microbe / 年: 2018 タイトル: HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design. 著者: Flyak, A.I. / Ruiz, S. / Colbert, M.D. / Luong, T. / Crowe Jr., J.E. / Bailey, J.R. / Bjorkman, P.J. |
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履歴 | 登録 | 2018年9月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年11月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年11月28日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name |
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改定 1.2 | 2019年11月6日 | Group: Data collection / Structure summary / カテゴリ: struct / Item: _struct.title |
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改定 1.3 | 2019年12月18日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 2.0 | 2020年7月29日 | Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Derived calculations / Source and taxonomy / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / entity_src_gen / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_validate_close_contact / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_validate_close_contact.auth_asym_id_2 / _pdbx_validate_close_contact.auth_seq_id_2 / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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