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Structure paper

TitleHCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.
Journal, issue, pagesCell Host Microbe, Vol. 24, Page 703-716.e3, Year 2018
Publish dateSep 6, 2018 (structure data deposition date)
AuthorsFlyak, A.I. / Ruiz, S. / Colbert, M.D. / Luong, T. / Crowe Jr., J.E. / Bailey, J.R. / Bjorkman, P.J.
External linksCell Host Microbe / PubMed:30439340
MethodsX-ray diffraction
Resolution1.36 - 3.1 Å
Structure data

PDB-6med:
Crystal structure of broadly neutralizing antibody HEPC3
Method: X-RAY DIFFRACTION / Resolution: 2.04 Å

PDB-6mee:
Crystal structure of broadly neutralizing antibody HEPC74
Method: X-RAY DIFFRACTION / Resolution: 1.36 Å

PDB-6mef:
Crystal structure of broadly neutralizing antibody AR3C
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-6meg:
Crystal structure of human monoclonal antibody HEPC46
Method: X-RAY DIFFRACTION / Resolution: 1.41 Å

PDB-6meh:
Crystal structure of broadly neutralizing antibody HEPC74 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

PDB-6mei:
Crystal structure of broadly neutralizing antibody HEPC3 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-6mej:
Crystal structure of Hepatitis C virus envelope glycoprotein E2 ectodomain in complex with human antibodies HEPC3 and HEPC46
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-6mek:
Crystal structure of Hepatitis C virus envelope glycoprotein E2 core in complex with human antibodies HEPC3 and HEPC46
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-SO4:
SULFATE ION / Sulfate

ChemComp-HOH:
WATER / Water

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

ChemComp-BR:
BROMIDE ION / Bromide

Source
  • homo sapiens (human)
  • hepacivirus c
KeywordsIMMUNE SYSTEM / HCV glycoprotein / broadly neutralizing antibodies

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