Entry Database : PDB / ID : 4lmq Structure visualization Downloads & linksTitle Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 ComponentsStromal cell-derived factor 1 hu30D8 Fab heavy chain hu30D8 Fab light chain DetailsKeywords cell adhesion/immune system / immunoglobulin / cell adhesion-immune system complexFunction / homology Function and homology informationFunction Domain/homology Component
chemokine (C-X-C motif) ligand 12 signaling pathway / negative regulation of leukocyte tethering or rolling / response to ultrasound / telencephalon cell migration / regulation of actin polymerization or depolymerization / CXCL12-activated CXCR4 signaling pathway / chemokine receptor binding / positive regulation of vasculature development / CXCR chemokine receptor binding / positive regulation of axon extension involved in axon guidance ... chemokine (C-X-C motif) ligand 12 signaling pathway / negative regulation of leukocyte tethering or rolling / response to ultrasound / telencephalon cell migration / regulation of actin polymerization or depolymerization / CXCL12-activated CXCR4 signaling pathway / chemokine receptor binding / positive regulation of vasculature development / CXCR chemokine receptor binding / positive regulation of axon extension involved in axon guidance / positive regulation of dopamine secretion / Signaling by ROBO receptors / induction of positive chemotaxis / integrin activation / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / negative regulation of dendritic cell apoptotic process / cellular response to chemokine / chemokine-mediated signaling pathway / positive regulation of monocyte chemotaxis / blood circulation / Chemokine receptors bind chemokines / chemokine activity / positive regulation of calcium ion import / detection of temperature stimulus involved in sensory perception of pain / positive regulation of cell adhesion / positive regulation of T cell migration / animal organ regeneration / detection of mechanical stimulus involved in sensory perception of pain / Nuclear signaling by ERBB4 / positive regulation of endothelial cell proliferation / positive regulation of neuron differentiation / adult locomotory behavior / cell chemotaxis / axon guidance / growth factor activity / neuron migration / response to virus / response to peptide hormone / defense response / intracellular calcium ion homeostasis / chemotaxis / integrin binding / G alpha (i) signalling events / collagen-containing extracellular matrix / Estrogen-dependent gene expression / cell adhesion / response to hypoxia / immune response / G protein-coupled receptor signaling pathway / external side of plasma membrane / signaling receptor binding / signal transduction / extracellular exosome / extracellular region Similarity search - Function CXC Chemokine domain / Chemokine beta/gamma/delta / Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). / Chemokine interleukin-8-like domain / Chemokine interleukin-8-like superfamily / Small cytokines (intecrine/chemokine), interleukin-8 like / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #40 / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Immunoglobulins / Immunoglobulin-like ... CXC Chemokine domain / Chemokine beta/gamma/delta / Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). / Chemokine interleukin-8-like domain / Chemokine interleukin-8-like superfamily / Small cytokines (intecrine/chemokine), interleukin-8 like / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #40 / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Immunoglobulins / Immunoglobulin-like / Beta Barrel / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.773 Å DetailsAuthors Zhong, Z. / Wang, J. / Li, B. / Xiang, H. / Ultsch, M. / Coons, M. / Wong, T. / Chiang, N.Y. / Clark, S. / Clark, R. ...Zhong, Z. / Wang, J. / Li, B. / Xiang, H. / Ultsch, M. / Coons, M. / Wong, T. / Chiang, N.Y. / Clark, S. / Clark, R. / Quintana, L. / Gribling, P. / Suto, E. / Barck, K. / Corpuz, R. / Yao, J. / Takkar, R. / Lee, W.P. / Damico-Beyer, L.A. / Carano, R.D. / Adams, C. / Kelley, R.F. / Wang, W. / Ferrara, N. CitationJournal : Clin.Cancer Res. / Year : 2013Title : Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12.Authors: Zhong, C. / Wang, J. / Li, B. / Xiang, H. / Ultsch, M. / Coons, M. / Wong, T. / Chiang, N.Y. / Clark, S. / Clark, R. / Quintana, L. / Gribling, P. / Suto, E. / Barck, K. / Corpuz, R. / Yao, ... Authors : Zhong, C. / Wang, J. / Li, B. / Xiang, H. / Ultsch, M. / Coons, M. / Wong, T. / Chiang, N.Y. / Clark, S. / Clark, R. / Quintana, L. / Gribling, P. / Suto, E. / Barck, K. / Corpuz, R. / Yao, J. / Takkar, R. / Lee, W.P. / Damico-Beyer, L.A. / Carano, R.D. / Adams, C. / Kelley, R.F. / Wang, W. / Ferrara, N. History Deposition Jul 10, 2013 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 14, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Aug 28, 2013 Group : Database referencesRevision 1.2 Jan 24, 2018 Group : Structure summary / Category : audit_author / Item : _audit_author.nameRevision 1.3 Oct 27, 2021 Group : Database references / Structure summary / Category : database_2 / entity / entity_name_comItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _entity.pdbx_fragment
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