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- PDB-5xti: Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 -

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Database: PDB / ID: 5xti
TitleCryo-EM architecture of human respiratory chain megacomplex-I2III2IV2
Components
  • (Cytochrome b-c1 complex subunit ...Coenzyme Q – cytochrome c reductase) x 9
  • (Cytochrome c oxidase subunit ...) x 13
  • (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit ...) x 12
  • (NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit ...) x 11
  • (NADH dehydrogenase [ubiquinone] 1 subunit ...) x 2
  • (NADH dehydrogenase [ubiquinone] flavoprotein ...) x 3
  • (NADH dehydrogenase [ubiquinone] iron-sulfur protein ...) x 7
  • (NADH-ubiquinone oxidoreductase chain ...) x 7
  • Acyl carrier protein, mitochondrial
  • Cytochrome b
  • Cytochrome c1, heme protein, mitochondrial
  • NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
KeywordsOXIDOREDUCTASE/ELECTRON TRANSPORT / Homo sapiens / Oxidoreductase / Respiratory / OXIDOREDUCTASE-ELECTRON TRANSPORT complex
Function / homologyThioredoxin-like [2Fe-2S] ferredoxin / Cytochrome c oxidase subunit 2, C-terminal / Cytochrome b-c1 complex subunit 7 superfamily / Cytochrome c oxidase, subunit VIIa superfamily / Cytochrome c oxidase, subunit VIa superfamily / NAD(P)-binding domain superfamily / Cytochrome C oxidase subunit II, transmembrane domain superfamily / Thioredoxin-like superfamily / Cytochrome b/b6, C-terminal domain superfamily / 2Fe-2S ferredoxin-like superfamily ...Thioredoxin-like [2Fe-2S] ferredoxin / Cytochrome c oxidase subunit 2, C-terminal / Cytochrome b-c1 complex subunit 7 superfamily / Cytochrome c oxidase, subunit VIIa superfamily / Cytochrome c oxidase, subunit VIa superfamily / NAD(P)-binding domain superfamily / Cytochrome C oxidase subunit II, transmembrane domain superfamily / Thioredoxin-like superfamily / Cytochrome b/b6, C-terminal domain superfamily / 2Fe-2S ferredoxin-like superfamily / Cytochrome c oxidase subunit III-like superfamily / Mitochondrial cytochrome c oxidase subunit VIc/VIIs / Cytochrome c oxidase subunit III domain / Cytochrome c oxidase, subunit 8 superfamily / Cytochrome c oxidase subunit I domain / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 / Deoxynucleoside kinase domain / Cytochrome b / Single alpha-helix domain superfamily / [NiFe]-hydrogenase, large subunit / P-loop containing nucleoside triphosphate hydrolase / Cytochrome b/b6-like domain superfamily / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 / NADH-ubiquinone oxidoreductase flavoprotein 3 / Cytochrome c oxidase, subunit Va/VI superfamily / Cytochrome c oxidase, subunit VIb superfamily / Cytochrome c oxidase subunit III / NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily / Respiratory-chain NADH dehydrogenase, 30 Kd subunit / NADH dehydrogenase / Cytochrome C oxidase subunit II, periplasmic domain / Cytochrome C and Quinol oxidase polypeptide I / Cytochrome b/b6/petB / Cytochrome b(C-terminal)/b6/petD / NADH dehydrogenase ubiquinone Fe-S protein 4-like superfamily / NADH:ubiquinone oxidoreductase, subunit 3 superfamily / NADH-quinone oxidoreductase, subunit D superfamily / NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily / NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily / Cytochrome c oxidase subunit VIIc superfamily / Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily / Cytochrome b-c1 complex subunit Rieske, transmembrane domain superfamily / Cytochrome c oxidase, subunit Vb superfamily / Cytochrome c oxidase-like, subunit I superfamily / Rieske [2Fe-2S] iron-sulphur domain superfamily / Cytochrome c-like domain superfamily / Ubiquinol-cytochrome C reductase hinge domain superfamily / ACP-like superfamily / Cytochrome b-c1 complex subunit 9 superfamily / Cytochrome b-c1 complex subunit 8 superfamily / Cytochrome c oxidase subunit IV superfamily / NADH-ubiquinone oxidoreductase 1 subunit C1 / Cytochrome c oxidase-like, subunit I domain / Rieske [2Fe-2S] domain / Peptidase M16, N-terminal / NADH-quinone oxidoreductase, chain G, C-terminal / Ubiquinol-cytochrome c reductase 8kDa, N-terminal / Cytochrome b-c1 complex subunit 10 / Rieske iron-sulphur protein / Cytochrome c oxidase, subunit II / NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site / Cytochrome c oxidase, subunit III, 4-helical bundle / Cytochrome c oxidase subunit IV / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 / NADH:ubiquinone oxidoreductase, MNLL subunit / Cytochrome C oxidase subunit II, transmembrane domain / Di-haem cytochrome, transmembrane / NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain / NADH ubiquinone oxidoreductase, F subunit / Metalloenzyme, LuxS/M16 peptidase-like / Globular protein, non-globular alpha/beta subunit / NADH dehydrogenase subunit 5, C-terminal / NADH dehydrogenase subunit 2, C-terminal / CHCH / NADH:ubiquinone oxidoreductase, subunit G / NADH-quinone oxidoreductase, chain M/4 / NADH-quinone oxidoreductase, chain I / NADH dehydrogenase, subunit C / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial / NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2 / Cytochrome c oxidase, subunit I, copper-binding site / NADH-ubiquinone oxidoreductase, subunit 10 / Cytochrome C oxidase, subunit VIIB domain superfamily / Ubiquinol-cytochrome C reductase hinge domain / NAD(P)H-quinone oxidoreductase subunit D/H / Cytochrome c1, transmembrane anchor, C-terminal / Cytochrome c oxidase, subunit Vb, zinc binding site / NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site / NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain / NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding / Soluble ligand binding domain / Zinc finger, CHCC-type / NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5 / NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 6 / NADH:ubiquinone oxidoreductase, ESSS subunit / NADH dehydrogenase 1, beta subcomplex, subunit 6 / NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit / Cytochrome c oxidase, subunit VIa, conserved site / NADH:ubiquinone oxidoreductase, subunit 1, conserved site
Function and homology information
Specimen sourceHomo sapiens (human)
Bos taurus (cattle)
MethodELECTRON MICROSCOPY / single particle reconstruction / cryo EM / 17.4 Å resolution
AuthorsGu, J. / Wu, M. / Yang, M.
CitationJournal: Cell / Year: 2017
Title: Architecture of Human Mitochondrial Respiratory Megacomplex IIIIIV.
Authors: Runyu Guo / Shuai Zong / Meng Wu / Jinke Gu / Maojun Yang
Abstract: The respiratory megacomplex represents the highest-order assembly of respiratory chain complexes, and it allows mitochondria to respond to energy-requiring conditions. To understand its architecture, ...The respiratory megacomplex represents the highest-order assembly of respiratory chain complexes, and it allows mitochondria to respond to energy-requiring conditions. To understand its architecture, we examined the human respiratory chain megacomplex-IIIIIV (MCIIIIIV) with 140 subunits and a subset of associated cofactors using cryo-electron microscopy. The MCIIIIIV forms a circular structure with the dimeric CIII located in the center, where it is surrounded by two copies each of CI and CIV. Two cytochrome c (Cyt.c) molecules are positioned to accept electrons on the surface of the c state CIII dimer. Analyses indicate that CII could insert into the gaps between CI and CIV to form a closed ring, which we termed the electron transport chain supercomplex. The structure not only reveals the precise assignment of individual subunits of human CI and CIII, but also enables future in-depth analysis of the electron transport chain as a whole.
Copyright: 2017 Elsevier Inc. All rights reserved.
Validation Report
SummaryFull reportAbout validation report
DateDeposition: Jun 19, 2017 / Release: Sep 13, 2017
RevisionDateData content typeGroupCategoryItemProviderType
1.0Sep 13, 2017Structure modelrepositoryInitial release
1.1Dec 6, 2017Structure modelData processing / Database referencescitation / em_software_citation.journal_volume / _citation.page_first / _citation.page_last / _em_software.name

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Structure visualization

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Assembly

Deposited unit
A: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
B: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
C: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
E: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
F: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
G: Acyl carrier protein, mitochondrial
H: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
I: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
J: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
K: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
L: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
M: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
N: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
O: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
P: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Q: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
S: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
T: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
U: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
V: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
W: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
X: Acyl carrier protein, mitochondrial
Y: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
Z: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
a: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
b: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
c: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
d: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
e: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
f: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
g: NADH dehydrogenase [ubiquinone] 1 subunit C2
h: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
i: NADH-ubiquinone oxidoreductase chain 2
j: NADH-ubiquinone oxidoreductase chain 3
k: NADH-ubiquinone oxidoreductase chain 4L
l: NADH-ubiquinone oxidoreductase chain 5
m: NADH-ubiquinone oxidoreductase chain 6
n: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
o: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
p: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
r: NADH-ubiquinone oxidoreductase chain 4
s: NADH-ubiquinone oxidoreductase chain 1
u: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
v: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
w: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
x: Cytochrome c oxidase subunit 1
y: Cytochrome c oxidase subunit 2
z: Cytochrome c oxidase subunit 3
0: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
1: Cytochrome c oxidase subunit 5A, mitochondrial
2: Cytochrome c oxidase subunit 5B, mitochondrial
3: Cytochrome c oxidase subunit 6A2, mitochondrial
4: Cytochrome c oxidase subunit 6B1
5: Cytochrome c oxidase subunit 6C
6: Cytochrome c oxidase subunit 7A1, mitochondrial
7: Cytochrome c oxidase subunit 7B, mitochondrial
8: Cytochrome c oxidase subunit 7C, mitochondrial
9: Cytochrome c oxidase subunit 8B, mitochondrial
AA: Cytochrome b-c1 complex subunit 8
AB: Cytochrome b-c1 complex subunit Rieske, mitochondrial
AC: Cytochrome b-c1 complex subunit Rieske, mitochondrial
AD: Cytochrome b-c1 complex subunit 9
AE: Cytochrome b-c1 complex subunit 6, mitochondrial
AF: Cytochrome b-c1 complex subunit 7
AG: Cytochrome b-c1 complex subunit 10
AH: Cytochrome c1, heme protein, mitochondrial
AJ: Cytochrome b
AK: Cytochrome b-c1 complex subunit 2, mitochondrial
AL: Cytochrome b-c1 complex subunit 1, mitochondrial
AN: Cytochrome b-c1 complex subunit 8
AO: Cytochrome b-c1 complex subunit Rieske, mitochondrial
AP: Cytochrome b-c1 complex subunit Rieske, mitochondrial
AQ: Cytochrome b-c1 complex subunit 9
AR: Cytochrome b-c1 complex subunit 6, mitochondrial
AS: Cytochrome b-c1 complex subunit 7
AT: Cytochrome b-c1 complex subunit 10
AU: Cytochrome c1, heme protein, mitochondrial
AV: Cytochrome b
AW: Cytochrome b-c1 complex subunit 2, mitochondrial
AY: Cytochrome b-c1 complex subunit 1, mitochondrial
BA: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
BB: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
BC: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
BE: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
BF: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
BG: Acyl carrier protein, mitochondrial
BH: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
BI: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
BJ: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
BK: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
BL: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
BM: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
BN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
BO: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
BP: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
BQ: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
BS: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
BT: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
BU: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
BV: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
BW: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
BX: Acyl carrier protein, mitochondrial
BY: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
BZ: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Ba: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Bb: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Bc: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
Bd: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Be: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Bf: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Bg: NADH dehydrogenase [ubiquinone] 1 subunit C2
Bh: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Bi: NADH-ubiquinone oxidoreductase chain 2
Bj: NADH-ubiquinone oxidoreductase chain 3
Bk: NADH-ubiquinone oxidoreductase chain 4L
Bl: NADH-ubiquinone oxidoreductase chain 5
Bm: NADH-ubiquinone oxidoreductase chain 6
Bn: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Bo: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Bp: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Br: NADH-ubiquinone oxidoreductase chain 4
Bs: NADH-ubiquinone oxidoreductase chain 1
Bu: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Bv: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Bw: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Bx: Cytochrome c oxidase subunit 1
By: Cytochrome c oxidase subunit 2
Bz: Cytochrome c oxidase subunit 3
B0: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
B1: Cytochrome c oxidase subunit 5A, mitochondrial
B2: Cytochrome c oxidase subunit 5B, mitochondrial
B3: Cytochrome c oxidase subunit 6A2, mitochondrial
B4: Cytochrome c oxidase subunit 6B1
B5: Cytochrome c oxidase subunit 6C
B6: Cytochrome c oxidase subunit 7A1, mitochondrial
B7: Cytochrome c oxidase subunit 7B, mitochondrial
B8: Cytochrome c oxidase subunit 7C, mitochondrial
B9: Cytochrome c oxidase subunit 8B, mitochondrial
hetero molecules


Theoretical massNumber of molelcules
Total (without water)2,828,803238
Polyers2,756,873138
Non-polymers71,929100
Water0
1


  • idetical with deposited unit
  • defined by author
  • Evidence: gel filtration
TypeNameSymmetry operationNumber
identity operation1_5551

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Components

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NADH dehydrogenase [ubiquinone] flavoprotein ... , 3 types, 6 molecules ABAKBKOBO

#1: Protein/peptide NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial / Complex I-51kD / CI-51kD / NADH dehydrogenase flavoprotein 1 / NADH-ubiquinone oxidoreductase 51 kDa subunit


Mass: 47323.938 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 27-457 / Source: (natural) Homo sapiens (human)
References: UniProt:P49821, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone)), EC:1.6.99.3 (NADH dehydrogenase)
#10: Protein/peptide NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial / Complex I-9kD / CI-9kD / NADH-ubiquinone oxidoreductase 9 kDa subunit / Renal carcinoma antigen NY-REN-4


Mass: 3900.312 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 74-106 / Source: (natural) Homo sapiens (human) / References: UniProt:P56181
#14: Protein/peptide NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial / NADH-ubiquinone oxidoreductase 24 kDa subunit


Mass: 23430.881 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 36-247 / Source: (natural) Homo sapiens (human)
References: UniProt:P19404, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone)), EC:1.6.99.3 (NADH dehydrogenase)

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NADH dehydrogenase [ubiquinone] iron-sulfur protein ... , 7 types, 14 molecules BBBCBCLBLPBPQBQTBThBh

#2: Protein/peptide NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial / Complex I-23kD / CI-23kD / NADH-ubiquinone oxidoreductase 23 kDa subunit / TYKY subunit


Mass: 20314.037 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human)
References: UniProt:O00217, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone)), EC:1.6.99.3 (NADH dehydrogenase)
#3: Protein/peptide NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial / Complex I-20kD / CI-20kD / NADH-ubiquinone oxidoreductase 20 kDa subunit / PSST subunit


Mass: 17887.928 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 58-213 / Source: (natural) Homo sapiens (human)
References: UniProt:O75251, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone)), EC:1.6.99.3 (NADH dehydrogenase)
#11: Protein/peptide NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial / Complex I-18 kDa / CI-18 kDa / Complex I-AQDQ / CI-AQDQ / NADH-ubiquinone oxidoreductase 18 kDa subunit


Mass: 13721.598 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 58-175 / Source: (natural) Homo sapiens (human) / References: UniProt:O43181
#15: Protein/peptide NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial / Complex I-30kD / CI-30kD / NADH-ubiquinone oxidoreductase 30 kDa subunit


Mass: 24432.656 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 43-250 / Source: (natural) Homo sapiens (human)
References: UniProt:O75489, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone)), EC:1.6.99.3 (NADH dehydrogenase)
#16: Protein/peptide NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial / Complex I-49kD / CI-49kD / NADH-ubiquinone oxidoreductase 49 kDa subunit


Mass: 49236.480 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human)
References: UniProt:O75306, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone)), EC:1.6.99.3 (NADH dehydrogenase)
#18: Protein/peptide NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial / Complex I-13kD-A / CI-13kD-A / NADH-ubiquinone oxidoreductase 13 kDa-A subunit


Mass: 10578.848 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 29-123 / Source: (natural) Homo sapiens (human) / References: UniProt:O75380
#31: Protein/peptide NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 / Complex I-15 kDa / CI-15 kDa / NADH-ubiquinone oxidoreductase 15 kDa subunit


Mass: 12314.254 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 2-105 / Source: (natural) Homo sapiens (human) / References: UniProt:O43920

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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit ... , 12 types, 24 molecules EBEFBFHBHIBIJBJNBNSBSUBUVBVWBWuBuwBw

#4: Protein/peptide NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 / Complex I-B14 / CI-B14 / LYR motif-containing protein 6 / NADH-ubiquinone oxidoreductase B14 subunit


Mass: 13758.070 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 42-154 / Source: (natural) Homo sapiens (human) / References: UniProt:P56556
#5: Protein/peptide NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 / Complex I-B8 / CI-B8 / NADH-ubiquinone oxidoreductase B8 subunit


Mass: 9535.905 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 14-96 / Source: (natural) Homo sapiens (human) / References: UniProt:O43678
#7: Protein/peptide NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 / Complex I subunit B13 / Complex I-13kD-B / CI-13kD-B / NADH-ubiquinone oxidoreductase 13 kDa-B subunit


Mass: 13119.208 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 5-116 / Source: (natural) Homo sapiens (human) / References: UniProt:Q16718
#8: Protein/peptide NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 / Complex I-B14.5a / CI-B14.5a / NADH-ubiquinone oxidoreductase subunit B14.5a


Mass: 12282.051 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 4-113 / Source: (natural) Homo sapiens (human) / References: UniProt:O95182
#9: Protein/peptide NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial / Complex I-39kD / CI-39kD / NADH-ubiquinone oxidoreductase 39 kDa subunit


Mass: 38387.594 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 40-376 / Source: (natural) Homo sapiens (human) / References: UniProt:Q16795
#13: Protein/peptide NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 / 13 kDa differentiation-associated protein / Complex I-B17.2 / CIB17.2 / NADH-ubiquinone oxidoreductase subunit B17.2


Mass: 16880.068 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 2-144 / Source: (natural) Homo sapiens (human) / References: UniProt:Q9UI09
#17: Protein/peptide NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 / Complex I-MWFE / CI-MWFE / NADH-ubiquinone oxidoreductase MWFE subunit


Mass: 8084.391 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human) / References: UniProt:O15239
#19: Protein/peptide NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 / Complex I-B9 / CI-B9 / NADH-ubiquinone oxidoreductase B9 subunit


Mass: 9156.602 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human) / References: UniProt:O95167
#20: Protein/peptide NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 / Complex I-B14.7 / CI-B14.7 / NADH-ubiquinone oxidoreductase subunit B14.7


Mass: 14736.853 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human) / References: UniProt:Q86Y39
#21: Protein/peptide NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 / Cell death regulatory protein GRIM-19 / Complex I-B16.6 / CI-B16.6 / Gene associated with retinoic and interferon-induced mortality 19 protein / Gene associated with retinoic and IFN-induced mortality 19 protein / NADH-ubiquinone oxidoreductase B16.6 subunit


Mass: 16132.570 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 7-144 / Source: (natural) Homo sapiens (human) / References: UniProt:Q9P0J0
#42: Protein/peptide NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 / Complex I-19kD / CI-19kD / Complex I-PGIV / CI-PGIV / NADH-ubiquinone oxidoreductase 19 kDa subunit


Mass: 19853.736 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 4-172 / Source: (natural) Homo sapiens (human) / References: UniProt:P51970
#44: Protein/peptide NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial / Complex I-42kD / CI-42kD / NADH-ubiquinone oxidoreductase 42 kDa subunit


Mass: 37200.270 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human) / References: UniProt:O95299

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Protein/peptide , 4 types, 10 molecules GXBGBXMBMAHAUAJAV

#6: Protein/peptide
Acyl carrier protein, mitochondrial / ACP / CI-SDAP / NADH-ubiquinone oxidoreductase 9.6 kDa subunit


Mass: 9845.247 Da / Num. of mol.: 4 / Fragment: UNP RESIDUES 72-196 / Source: (natural) Homo sapiens (human) / References: UniProt:O14561
#12: Protein/peptide NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial / Complex I-75kD / CI-75kD


Mass: 75471.484 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 30-716 / Source: (natural) Homo sapiens (human)
References: UniProt:P28331, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone)), EC:1.6.99.3 (NADH dehydrogenase)
#65: Protein/peptide Cytochrome c1, heme protein, mitochondrial / Complex III subunit 4 / Complex III subunit IV / Cytochrome b-c1 complex subunit 4 / Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit / Cytochrome c-1


Mass: 27388.395 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human) / References: UniProt:P08574
#66: Protein/peptide Cytochrome b / / Complex III subunit 3 / Complex III subunit III / Cytochrome b-c1 complex subunit 3 / Ubiquinol-cytochrome-c reductase complex cytochrome b subunit


Mass: 42543.016 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 2-479 / Source: (natural) Homo sapiens (human) / References: UniProt:P00156

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NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit ... , 11 types, 22 molecules YBYZBZaBabBbcBcdBdeBenBnoBopBpvBv

#22: Protein/peptide NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial / Complex I-AGGG / CI-AGGG / NADH-ubiquinone oxidoreductase AGGG subunit


Mass: 7468.270 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 39-97 / Source: (natural) Homo sapiens (human) / References: UniProt:O95178
#23: Protein/peptide NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 / Complex I-B12 / CI-B12 / NADH-ubiquinone oxidoreductase B12 subunit


Mass: 9261.605 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 10-89 / Source: (natural) Homo sapiens (human) / References: UniProt:O43676
#24: Protein/peptide NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial / Complex I-SGDH / CI-SGDH / NADH-ubiquinone oxidoreductase SGDH subunit


Mass: 16573.160 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 52-189 / Source: (natural) Homo sapiens (human) / References: UniProt:O43674
#25: Protein/peptide NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 / Complex I-B17 / CI-B17 / NADH-ubiquinone oxidoreductase B17 subunit


Mass: 15008.635 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 3-126 / Source: (natural) Homo sapiens (human) / References: UniProt:O95139
#26: Protein/peptide NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial / Complex I-ASHI / CI-ASHI / NADH-ubiquinone oxidoreductase ASHI subunit


Mass: 18267.562 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 34-186 / Source: (natural) Homo sapiens (human) / References: UniProt:O95169
#27: Protein/peptide NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 / Complex I-PDSW / CI-PDSW / NADH-ubiquinone oxidoreductase PDSW subunit


Mass: 20721.650 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 1-171 / Source: (natural) Homo sapiens (human) / References: UniProt:O96000
#28: Protein/peptide NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial / Complex I-ESSS / CI-ESSS / NADH-ubiquinone oxidoreductase ESSS subunit / Neuronal protein 17.3 / p17.3


Mass: 11494.942 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 54-150 / Source: (natural) Homo sapiens (human) / References: UniProt:Q9NX14
#37: Protein/peptide NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 / Complex I-MNLL / CI-MNLL / NADH-ubiquinone oxidoreductase MNLL subunit


Mass: 6741.883 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 3-58 / Source: (natural) Homo sapiens (human) / References: UniProt:O75438
#38: Protein/peptide NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 / Complex I-B15 / CI-B15 / NADH-ubiquinone oxidoreductase B15 subunit


Mass: 15100.399 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human) / References: UniProt:O95168
#39: Protein/peptide NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 / Complex I-B22 / CI-B22 / LYR motif-containing protein 3 / NADH-ubiquinone oxidoreductase B22 subunit


Mass: 21189.141 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 8-179 / Source: (natural) Homo sapiens (human) / References: UniProt:Q9Y6M9
#43: Protein/peptide NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 / Cell adhesion protein SQM1 / Complex I-B18 / CI-B18 / NADH-ubiquinone oxidoreductase B18 subunit


Mass: 14997.401 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 3-124 / Source: (natural) Homo sapiens (human) / References: UniProt:P17568

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NADH dehydrogenase [ubiquinone] 1 subunit ... , 2 types, 4 molecules fBfgBg

#29: Protein/peptide NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial / Complex I-KFYI / CI-KFYI / NADH-ubiquinone oxidoreductase KFYI subunit


Mass: 5704.602 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 28-74 / Source: (natural) Homo sapiens (human) / References: UniProt:O43677
#30: Protein/peptide NADH dehydrogenase [ubiquinone] 1 subunit C2 / Complex I-B14.5b / CI-B14.5b / Human lung cancer oncogene 1 protein / HLC-1 / NADH-ubiquinone oxidoreductase subunit B14.5b


Mass: 14209.521 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human) / References: UniProt:O95298

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NADH-ubiquinone oxidoreductase chain ... , 7 types, 14 molecules iBijBjkBklBlmBmrBrsBs

#32: Protein/peptide NADH-ubiquinone oxidoreductase chain 2


Mass: 39007.656 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human)
References: UniProt:Q4GRX1, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone))
#33: Protein/peptide NADH-ubiquinone oxidoreductase chain 3


Mass: 13147.871 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 1-115 / Source: (natural) Homo sapiens (human)
References: UniProt:B9EE38, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone))
#34: Protein/peptide NADH-ubiquinone oxidoreductase chain 4L


Mass: 10702.086 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 1-97 / Source: (natural) Homo sapiens (human)
References: UniProt:V9JN72, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone))
#35: Protein/peptide NADH-ubiquinone oxidoreductase chain 5


Mass: 67096.023 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human)
References: UniProt:X5BVZ3, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone))
#36: Protein/peptide NADH-ubiquinone oxidoreductase chain 6


Mass: 18660.979 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human)
References: UniProt:Q8HAX7, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone))
#40: Protein/peptide NADH-ubiquinone oxidoreductase chain 4


Mass: 51689.688 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human)
References: UniProt:B2XJG5, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone))
#41: Protein/peptide NADH-ubiquinone oxidoreductase chain 1


Mass: 35621.215 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human)
References: UniProt:H9PGF0, EC:1.6.5.3 (NADH dehydrogenase (ubiquinone))

+
Cytochrome c oxidase subunit ... , 13 types, 26 molecules xBxyByzBz0B01B12B23B34B45B56B67B78B89B9

#45: Protein/peptide Cytochrome c oxidase subunit 1 / Cytochrome c oxidase polypeptide I


Mass: 57065.844 Da / Num. of mol.: 2 / Source: (natural) Bos taurus (cattle)
References: UniProt:P00396, EC:1.9.3.1 (cytochrome-c oxidase)
#46: Protein/peptide Cytochrome c oxidase subunit 2 / Cytochrome c oxidase polypeptide II


Mass: 26040.393 Da / Num. of mol.: 2 / Source: (natural) Bos taurus (cattle) / References: UniProt:P68530
#47: Protein/peptide Cytochrome c oxidase subunit 3 / Cytochrome c oxidase polypeptide III


Mass: 29957.627 Da / Num. of mol.: 2 / Source: (natural) Bos taurus (cattle) / References: UniProt:P00415
#48: Protein/peptide Cytochrome c oxidase subunit 4 isoform 1, mitochondrial / Cytochrome c oxidase polypeptide IV / Cytochrome c oxidase subunit IV isoform 1 / COX IV-1


Mass: 16913.367 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 26-169 / Source: (natural) Bos taurus (cattle) / References: UniProt:P00423
#49: Protein/peptide Cytochrome c oxidase subunit 5A, mitochondrial / Cytochrome c oxidase polypeptide Va


Mass: 12453.081 Da / Num. of mol.: 2 / Source: (natural) Bos taurus (cattle) / References: UniProt:P00426
#50: Protein/peptide Cytochrome c oxidase subunit 5B, mitochondrial / Cytochrome c oxidase polypeptide VIa / Cytochrome c oxidase polypeptide Vb


Mass: 10684.038 Da / Num. of mol.: 2 / Source: (natural) Bos taurus (cattle) / References: UniProt:P00428
#51: Protein/peptide Cytochrome c oxidase subunit 6A2, mitochondrial / Cytochrome c oxidase polypeptide VIa-heart / COXVIAH / Cytochrome c oxidase polypeptide VIb


Mass: 9452.687 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 13-96 / Source: (natural) Bos taurus (cattle) / References: UniProt:P07471
#52: Protein/peptide Cytochrome c oxidase subunit 6B1 / Cytochrome c oxidase polypeptide VII / Cytochrome c oxidase subunit AED / Cytochrome c oxidase subunit VIb isoform 1 / COX VIb-1


Mass: 8925.979 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 12-86 / Source: (natural) Bos taurus (cattle) / References: UniProt:P00429
#53: Protein/peptide Cytochrome c oxidase subunit 6C / Cytochrome c oxidase polypeptide VIc / Cytochrome c oxidase subunit STA


Mass: 8494.982 Da / Num. of mol.: 2 / Source: (natural) Bos taurus (cattle) / References: UniProt:P04038
#54: Protein/peptide Cytochrome c oxidase subunit 7A1, mitochondrial / Cytochrome c oxidase subunit VIIIc / VIIIC / Cytochrome c oxidase subunit VIIa-heart / Cytochrome c oxidase subunit VIIa-H / Cytochrome c oxidase subunit VIIa-muscle / Cytochrome c oxidase subunit VIIa-M


Mass: 6286.220 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 22-77 / Source: (natural) Bos taurus (cattle) / References: UniProt:P07470
#55: Protein/peptide Cytochrome c oxidase subunit 7B, mitochondrial / Cytochrome c oxidase polypeptide VIIb / IHQ


Mass: 5442.168 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 30-78 / Source: (natural) Bos taurus (cattle) / References: UniProt:P13183
#56: Protein/peptide Cytochrome c oxidase subunit 7C, mitochondrial / Cytochrome c oxidase polypeptide VIIIA / Cytochrome c oxidase polypeptide VIIc


Mass: 5449.396 Da / Num. of mol.: 2 / Source: (natural) Bos taurus (cattle) / References: UniProt:P00430
#57: Protein/peptide Cytochrome c oxidase subunit 8B, mitochondrial / Cytochrome c oxidase polypeptide VIII-heart / Cytochrome c oxidase subunit 8-1 / Cytochrome c oxidase subunit 8H / IX / VIIIb


Mass: 4738.523 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 25-67 / Source: (natural) Bos taurus (cattle) / References: UniProt:P10175

+
Cytochrome b-c1 complex subunit ... , 9 types, 18 molecules AAANABAOACAPADAQAEARAFASAGATAKAWALAY

#58: Protein/peptide Cytochrome b-c1 complex subunit 8 / Coenzyme Q – cytochrome c reductase / Complex III subunit 8 / Complex III subunit VIII / Ubiquinol-cytochrome c reductase complex 9.5 kDa protein / Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C


Mass: 9791.181 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human) / References: UniProt:O14949
#59: Protein/peptide Cytochrome b-c1 complex subunit Rieske, mitochondrial / Coenzyme Q – cytochrome c reductase / Complex III subunit 5 / Cytochrome b-c1 complex subunit 5 / Rieske iron-sulfur protein / RISP / Ubiquinol-cytochrome c reductase iron-sulfur subunit


Mass: 5893.814 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 1-57 / Source: (natural) Homo sapiens (human)
References: UniProt:P47985, EC:1.10.2.2 (ubiquinol—cytochrome-c reductase)
#60: Protein/peptide Cytochrome b-c1 complex subunit Rieske, mitochondrial / Coenzyme Q – cytochrome c reductase / Complex III subunit 5 / Cytochrome b-c1 complex subunit 5 / Rieske iron-sulfur protein / RISP / Ubiquinol-cytochrome c reductase iron-sulfur subunit


Mass: 21645.578 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human)
References: UniProt:P47985, EC:1.10.2.2 (ubiquinol—cytochrome-c reductase)
#61: Protein/peptide Cytochrome b-c1 complex subunit 9 / Coenzyme Q – cytochrome c reductase / Complex III subunit 9 / Complex III subunit X / Cytochrome c1 non-heme 7 kDa protein / Ubiquinol-cytochrome c reductase complex 7.2 kDa protein


Mass: 7189.299 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human) / References: UniProt:Q9UDW1
#62: Protein/peptide Cytochrome b-c1 complex subunit 6, mitochondrial / Coenzyme Q – cytochrome c reductase / Complex III subunit 6 / Complex III subunit VIII / Cytochrome c1 non-heme 11 kDa protein / Mitochondrial hinge protein / Ubiquinol-cytochrome c reductase complex 11 kDa protein


Mass: 8861.742 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 18-91 / Source: (natural) Homo sapiens (human) / References: UniProt:P07919
#63: Protein/peptide Cytochrome b-c1 complex subunit 7 / Coenzyme Q – cytochrome c reductase / Complex III subunit 7 / Complex III subunit VII / QP-C / Ubiquinol-cytochrome c reductase complex 14 kDa protein


Mass: 13037.842 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 6-111 / Source: (natural) Homo sapiens (human) / References: UniProt:P14927
#64: Protein/peptide Cytochrome b-c1 complex subunit 10 / Coenzyme Q – cytochrome c reductase / Complex III subunit 10 / Complex III subunit XI / Ubiquinol-cytochrome c reductase complex 6.4 kDa protein


Mass: 5958.912 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 2-52 / Source: (natural) Homo sapiens (human) / References: UniProt:O14957
#67: Protein/peptide Cytochrome b-c1 complex subunit 2, mitochondrial / Coenzyme Q – cytochrome c reductase / Complex III subunit 2 / Core protein II / Ubiquinol-cytochrome-c reductase complex core protein 2


Mass: 44946.582 Da / Num. of mol.: 2 / Fragment: UNP RESIDUES 35-453 / Source: (natural) Homo sapiens (human) / References: UniProt:P22695
#68: Protein/peptide Cytochrome b-c1 complex subunit 1, mitochondrial / Coenzyme Q – cytochrome c reductase / Complex III subunit 1 / Core protein I / Ubiquinol-cytochrome-c reductase complex core protein 1


Mass: 49181.430 Da / Num. of mol.: 2 / Source: (natural) Homo sapiens (human) / References: UniProt:P31930

+
Non-polymers , 14 types, 100 molecules

#69: Chemical
ChemComp-SF4 / IRON/SULFUR CLUSTER


Mass: 351.640 Da / Num. of mol.: 12 / Formula: Fe4S4
#70: Chemical ChemComp-FMN / FLAVIN MONONUCLEOTIDE / RIBOFLAVIN MONOPHOSPHATE


Mass: 456.344 Da / Num. of mol.: 2 / Formula: C17H21N4O9P / Flavin mononucleotide
#71: Chemical...
ChemComp-PLX / (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL


Mass: 767.132 Da / Num. of mol.: 21 / Formula: C42H89NO8P
#72: Chemical
ChemComp-8Q1 / S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate / S-dodecanoyl-4'-phosphopantetheine


Mass: 540.651 Da / Num. of mol.: 4 / Formula: C23H45N2O8PS
#73: Chemical ChemComp-NDP / NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE


Mass: 745.421 Da / Num. of mol.: 2 / Formula: C21H30N7O17P3
#74: Chemical
ChemComp-FES / FE2/S2 (INORGANIC) CLUSTER


Mass: 175.820 Da / Num. of mol.: 6 / Formula: Fe2S2
#75: Chemical
ChemComp-CDL / CARDIOLIPIN / DIPHOSPHATIDYL GLYCEROL / BIS-(1,2-DIACYL-SN-GLYCERO-3-PHOSPHO)-1',3'-SN-GLYCEROL


Mass: 1464.043 Da / Num. of mol.: 19 / Formula: C81H156O17P2 / Cardiolipin / Comment: phospholipid *YM
#76: Chemical
ChemComp-PEE / 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine / DOPE


Mass: 749.073 Da / Num. of mol.: 14 / Formula: C41H83NO8P / Discrete optimized protein energy / Comment: DOPE (phospholipid) *YM
#77: Chemical
ChemComp-CU / COPPER (II) ION


Mass: 63.546 Da / Num. of mol.: 6 / Formula: Cu / Copper
#78: Chemical ChemComp-MG / MAGNESIUM ION


Mass: 24.305 Da / Num. of mol.: 2 / Formula: Mg / Magnesium
#79: Chemical
ChemComp-HEA / HEME-A


Mass: 852.837 Da / Num. of mol.: 4 / Formula: C49H56FeN4O6 / Heme A
#80: Chemical ChemComp-ZN / ZINC ION


Mass: 65.409 Da / Num. of mol.: 2 / Formula: Zn / Zinc
#81: Chemical ChemComp-HEC / HEME C


Mass: 618.503 Da / Num. of mol.: 2 / Formula: C34H34FeN4O4 / Heme C
#82: Chemical
ChemComp-HEM / PROTOPORPHYRIN IX CONTAINING FE / HEME


Mass: 616.487 Da / Num. of mol.: 4 / Formula: C34H32FeN4O4 / Heme

-
Experimental details

-
Experiment

ExperimentMethod: ELECTRON MICROSCOPY
EM experimentAggregation state: PARTICLE / Reconstruction method: single particle reconstruction

-
Sample preparation

ComponentName: Human respiratory chain megacomplex-I2III2IV2 / Type: COMPLEX
Entity ID: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68
Source: NATURAL
Source (natural)Organism: Homo sapiens (human)
Buffer solutionpH: 7.4
SpecimenEmbedding applied: NO / Shadowing applied: NO / Staining applied: NO / Vitrification applied: YES
VitrificationCryogen name: ETHANE

-
Electron microscopy imaging

Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company
MicroscopyMicroscope model: FEI TITAN KRIOS
Electron gunElectron source: FIELD EMISSION GUN / Accelerating voltage: 300 kV / Illumination mode: OTHER
Electron lensMode: BRIGHT FIELDBright-field microscopy
Image recordingElectron dose: 1.25 e/Å2 / Film or detector model: FEI FALCON II (4k x 4k)

-
Processing

EM software
IDNameVersionCategory
1EMAN2.1particle selection
2AutoEMation2.0image acquisition
4CTFFIND3.0CTF correction
7Coot0.8.2model fitting
9RELION1.4initial Euler assignment
10RELION1.4final Euler assignment
12RELION1.43D reconstruction
13PHENIX1.11.1model refinement
CTF correctionType: NONE
SymmetryPoint symmetry: C1
3D reconstructionResolution: 17.4 Å / Resolution method: FSC 0.143 CUT-OFF / Number of particles: 8600 / Symmetry type: POINT

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