EMDB-10054: Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaet...

Basic information

• Entry: Database: EMDB / ID: EMD-10054
• Title: Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state C

Sample

• Complex: 90S pre-ribosome, state C
  • Protein or peptide: x 61 types
  • RNA: x 2 types
• Ligand: x 1 types

• Keywords: ribosome / ribosome biogenesis / rRNA

Function / homology

Function:

box H/ACA snoRNP complex / snRNA pseudouridine synthesis / tRNA cytidine N4-acetyltransferase activity / rRNA acetylation involved in maturation of SSU-rRNA / 18S rRNA cytidine N-acetyltransferase activity / Noc4p-Nop14p complex / tRNA acetylation / CURI complex / UTP-C complex / t-UTP complex / Mpp10 complex / Pwp2p-containing subcomplex of 90S preribosome / rRNA (pseudouridine) methyltransferase activity / box C/D sno(s)RNA 3'-end processing / endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / rRNA methyltransferase activity / endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / box C/D methylation guide snoRNP complex / positive regulation of rRNA processing / tRNA export from nucleus / rRNA primary transcript binding / rRNA base methylation / sno(s)RNA-containing ribonucleoprotein complex / histone H2AQ104 methyltransferase activity / U3 snoRNA binding / snoRNA binding / preribosome, small subunit precursor / positive regulation of transcription by RNA polymerase I / 90S preribosome / RNA processing / Transferases; Acyltransferases; Transferring groups other than aminoacyl groups / RNA endonuclease activity / maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / methyltransferase activity / maturation of SSU-rRNA / small-subunit processome / mRNA splicing, via spliceosome / rRNA processing / ribosome biogenesis / ribosomal small subunit biogenesis / ribosomal small subunit assembly / small ribosomal subunit / cytosolic small ribosomal subunit / small ribosomal subunit rRNA binding / nuclear membrane / methylation / tRNA binding / rRNA binding / protein ubiquitination / ribosome / structural constituent of ribosome / translation / ribonucleoprotein complex / GTPase activity / GTP binding / nucleolus / RNA binding / ATP binding / nucleus / cytosol / cytoplasm

Domain/homology:

WD repeat-containing protein 75 first beta-propeller / Apoptosis-antagonizing transcription factor, C-terminal / AATF leucine zipper-containing domain / Protein AATF/Bfr2 / : / Apoptosis-antagonizing transcription factor, C-terminal / Apoptosis antagonizing transcription factor / NUC153 / Nucleolar protein 10/Enp2 / : / : / NUC153 domain / Nucleolar protein 10-like, second domain / Nucleolar protein 10-like, N-terminal domain / U3 small nucleolar RNA-associated protein 20, N-terminal / U3 snoRNA associated / Nucleolar complex protein 4 / U3 small nucleolar RNA-associated protein 20, C-terminal / : / U3 small nucleolar RNA-associated protein 20, N-terminal / U3 snoRNA associated / U3 small nucleolar RNA-associated protein 20 domain / Small subunit processome component 20 homolog, C-terminal / Ribosomal RNA assembly KRR1 / : / : / : / KRR1 small subunit processome component, second KH domain / Possible tRNA binding domain / RNA cytidine acetyltransferase NAT10 / Possible tRNA binding domain / Helicase domain / tRNA(Met) cytidine acetyltransferase TmcA, N-terminal / TmcA/NAT10/Kre33 / RNA cytidine acetyltransferase NAT10/TcmA, helicase domain / tRNA(Met) cytidine acetyltransferase TmcA, N-terminal / GNAT acetyltransferase 2 / Nucleolar protein 14 / Nop14-like family / NOL6/Upt22 / Nrap protein domain 1 / Nrap protein, domain 2 / Nrap protein, domain 3 / Nrap protein, domain 4 / Nrap protein, domain 5 / Nrap protein, domain 6 / Nrap protein domain 1 / Nrap protein PAP/OAS-like domain / Nrap protein domain 3 / Nrap protein nucleotidyltransferase domain 4 / Nrap protein PAP/OAS1-like domain 5 / Nrap protein domain 6 / U3 small nucleolar RNA-associated protein 6 / Ribosomal RNA-processing protein 7, C-terminal domain / Ribosomal RNA-processing protein 7 / Rrp7, RRM-like N-terminal domain / U3 small nucleolar RNA-associated protein 4 / : / U3 small nucleolar RNA-associated protein 6 / Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain / Rrp7 RRM-like N-terminal domain / Small-subunit processome, Utp11 / Sof1-like protein / BING4, C-terminal domain / Fcf2 pre-rRNA processing, C-terminal / Fcf2/DNTTIP2 / WD repeat-containing protein WDR46/Utp7 / : / : / Utp11 protein / Sof1-like domain / BING4CT (NUC141) domain / Fcf2 pre-rRNA processing / BING4CT (NUC141) domain / : / Small-subunit processome, Utp14 / U3 small nucleolar RNA-associated protein 15, C-terminal / Utp14 protein / UTP15 C terminal / Sas10 C-terminal domain / Sas10 C-terminal domain / Nucleolar protein 58/56, N-terminal / U3 small nucleolar RNA-associated protein 18 / NOP5NT (NUC127) domain / : / BP28, C-terminal domain / U3 small nucleolar RNA-associated protein 10, N-terminal / Ribosome biogenesis protein Bms1, N-terminal / U3 small nucleolar RNA-associated protein 10 / : / BP28CT (NUC211) domain / U3 small nucleolar RNA-associated protein 10 / HEATR1-like, HEAT repeats / BP28CT (NUC211) domain / U3 small nucleolar RNA-associated protein 13, C-terminal / Periodic tryptophan protein 2 / Utp13 specific WD40 associated domain / Small-subunit processome, Utp12 / Dip2/Utp12 Family / Sas10/Utp3/C1D

Component:

40S ribosomal protein s23-like protein / 40S ribosomal protein S6 / 40S ribosomal protein S8 / DDB1- and CUL4-associated factor 13 / Nucleolar protein 58 / Small-subunit processome Utp12 domain-containing protein / BING4 C-terminal domain-containing protein / CCAAT-binding factor domain-containing protein / Small-subunit processome Utp12 domain-containing protein / 40S ribosomal protein S13-like protein / RNA 3'-terminal phosphate cyclase-like protein / 40S ribosomal protein s9-like protein / 40S ribosomal protein S4 / Ribosomal protein s27-like protein / 40S ribosomal protein s5-like protein / RNA cytidine acetyltransferase / U3 small nucleolar RNA-associated protein 22 / Nucleolar protein 56 / U3 snoRNP protein / Pre-rRNA-processing protein PNO1 / KRR1 small subunit processome component / Bms1-type G domain-containing protein / Fcf2 pre-rRNA processing C-terminal domain-containing protein / Sas10 C-terminal domain-containing protein / Uncharacterized protein / Bystin-like protein / U3 small nucleolar RNA-associated protein 10 / Uncharacterized protein / Putative ribosomal protein / Small ribosomal subunit protein eS1 / Putative U3 snoRNP protein / 40S ribosomal protein S7 / Uncharacterized protein / Ribosome biogenesis protein ENP2 / Putative U3 small nucleolar ribonucleoprotein protein / 40S ribosomal protein S28-like protein / Protein BFR2 / Nucleolar essential protein 1 / Uncharacterized protein / 40S ribosomal protein S16-like protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Nucleolar complex protein 14 / U3 small nucleolar ribonucleoprotein protein IMP4 / U3 small nucleolar RNA-associated protein 15 C-terminal domain-containing protein / 40S ribosomal protein S11-like protein / U3 small nucleolar RNA-associated protein 11 / Periodic tryptophan protein 2-like protein / 40S ribosomal protein S19-like protein / 40S ribosomal protein S14-like protein / Ribosomal RNA-processing protein / U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein / H/ACA ribonucleoprotein complex subunit 2 / rRNA 2'-O-methyltransferase fibrillarin / 40S ribosomal protein S22-like protein / Uncharacterized protein / Uncharacterized protein CTHT_0071780 / Small ribosomal subunit protein eS24

• Biological species: Chaetomium thermophilum (fungus)
• Method: single particle reconstruction / cryo EM / Resolution: 7.1 Å
• Authors: Cheng J / Kellner N
• Citation: Journal: Mol Cell / Year: 2019; Title: Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.; Authors: Jingdong Cheng / Jochen Baßler / Paulina Fischer / Benjamin Lau / Nikola Kellner / Ruth Kunze / Sabine Griesel / Martina Kallas / Otto Berninghausen / Daniela Strauss / Roland Beckmann / Ed Hurt / ; Abstract: Eukaryotic ribosome biogenesis involves RNA folding and processing that depend on assembly factors and small nucleolar RNAs (snoRNAs). The 90S (SSU-processome) is the earliest pre-ribosome structurally analyzed, which was suggested to assemble stepwise along the growing pre-rRNA from 5' > 3', but this directionality may not be accurate. Here, by analyzing the structure of a series of 90S assembly intermediates from Chaetomium thermophilum, we discover a reverse order of 18S rRNA subdomain incorporation. Large parts of the 18S rRNA 3' and central domains assemble first into the 90S before the 5' domain is integrated. This final incorporation depends on a contact between a heterotrimer Enp2-Bfr2-Lcp5 recruited to the flexible 5' domain and Kre33, which reconstitutes the Kre33-Enp-Brf2-Lcp5 module on the compacted 90S. Keeping the 5' domain temporarily segregated from the 90S scaffold could provide extra time to complete the multifaceted 5' domain folding, which depends on a distinct set of snoRNAs and processing factors.

History

Deposition	Jun 10, 2019	-
Header (metadata) release	Aug 14, 2019	-
Map release	Aug 14, 2019	-
Update	May 22, 2024	-
Current status	May 22, 2024	Processing site: PDBe / Status: Released

Map

• File: Download / File: emd_10054.map.gz / Format: CCP4 / Size: 421.9 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
• Voxel size: X=Y=Z: 1.084 Å

Density

Contour Level	By AUTHOR: 0.03 / Movie #1: 0.03
Minimum - Maximum	-0.10431289 - 0.17114446
Average (Standard dev.)	0.0011899293 (±0.008101781)

• Symmetry: Space group: 1

Details

EMDB XML:

Map geometry	Axis order X Y Z Origin 0 0 0 Dimensions 480 480 480 Spacing 480 480 480
Cell	A=B=C: 520.32 Å α=β=γ: 90.0 °

CCP4 map header:

mode	Image stored as Reals
Å/pix. X/Y/Z	1.084	1.084	1.084
M x/y/z	480	480	480
origin x/y/z	0.000	0.000	0.000
length x/y/z	520.320	520.320	520.320
α/β/γ	90.000	90.000	90.000
MAP C/R/S	1	2	3
start NC/NR/NS	0	0	0
NC/NR/NS	480	480	480
D min/max/mean	-0.104	0.171	0.001

Supplemental data

Sample components

Entire : 90S pre-ribosome, state C

• Entire: Name: 90S pre-ribosome, state C

Components

• Complex: 90S pre-ribosome, state C
  • Protein or peptide: Periodic tryptophan protein 2-like protein
  • Protein or peptide: Utp3
  • Protein or peptide: Utp6
  • Protein or peptide: Utp7
  • Protein or peptide: U3 small nucleolar RNA-associated protein 11
  • Protein or peptide: Utp12
  • Protein or peptide: Utp13
  • Protein or peptide: Utp14
  • Protein or peptide: Utp18
  • Protein or peptide: Putative U3 snoRNP protein
  • Protein or peptide: Utp24
  • Protein or peptide: Imp3
  • Protein or peptide: Putative U3 small nucleolar ribonucleoprotein
  • Protein or peptide: Putative U3 small nucleolar ribonucleoprotein protein
  • Protein or peptide: Sof1
  • Protein or peptide: Emg1
  • Protein or peptide: KRR1 small subunit processome component
  • Protein or peptide: Pre-rRNA-processing protein PNO1
  • Protein or peptide: 40S ribosomal protein S1
  • Protein or peptide: 40S ribosomal protein s5-like protein
  • Protein or peptide: 40S ribosomal protein S7
  • Protein or peptide: 40S ribosomal protein s9-like protein
  • Protein or peptide: 40S ribosomal protein S13-like protein
  • Protein or peptide: 40S ribosomal protein S14-like protein
  • Protein or peptide: 40S ribosomal protein S16-like protein
  • Protein or peptide: 40S ribosomal protein S22-like protein
  • Protein or peptide: 40S ribosomal protein s23-like protein
  • Protein or peptide: 40S ribosomal protein S28-like protein
  • Protein or peptide: Ribosomal protein s27-like protein
  • Protein or peptide: Faf1
  • RNA: 35S ribosomal RNA
  • Protein or peptide: U3 small nucleolar RNA-associated protein 22
  • Protein or peptide: Rrp7
  • Protein or peptide: Putative ribosomal protein
  • Protein or peptide: RNA 3'-terminal phosphate cyclase-like protein
  • Protein or peptide: Bms1
  • Protein or peptide: Kre33
  • Protein or peptide: 40S ribosomal protein S4
  • Protein or peptide: 40S ribosomal protein S6
  • Protein or peptide: 40S ribosomal protein S8
  • Protein or peptide: 40S ribosomal protein S11-like protein
  • Protein or peptide: 40S ribosomal protein S24
  • Protein or peptide: Ribosome biogenesis protein ENP2
  • Protein or peptide: Utp20
  • Protein or peptide: Bfr2
  • Protein or peptide: Utp2
  • Protein or peptide: Utp4
  • Protein or peptide: UTP10
  • Protein or peptide: Utp15
  • Protein or peptide: Utp17
  • Protein or peptide: Enp1
  • Protein or peptide: Utp5
  • Protein or peptide: Utp16
  • Protein or peptide: Utp8
  • Protein or peptide: Noc4
  • Protein or peptide: Nop1
  • Protein or peptide: Putative nucleolar protein
  • Protein or peptide: Nop58
  • Protein or peptide: Snu13
  • Protein or peptide: Rrp9
  • Protein or peptide: Fcf2
  • RNA: U3 snoRNA
  • Protein or peptide: 40S ribosomal protein S19-like protein
• Ligand: ZINC ION

Supramolecule #1: 90S pre-ribosome, state C

• Supramolecule: Name: 90S pre-ribosome, state C / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#63
• Source (natural): Organism: Chaetomium thermophilum (fungus)

Macromolecule #1: Periodic tryptophan protein 2-like protein

• Macromolecule: Name: Periodic tryptophan protein 2-like protein / type: protein_or_peptide / ID: 1 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 100.817508 KDa

Sequence

String:

MKTNFKFSNL LGTVYCRGNL LFSPDGTHLF SPVGNRVTVF NLVENKSYTF PFAHRKNISR IGLTPQGNLL LSIDEDGQAI LTNVPRRVV LYHFSFKSPV TALAFSPSGR HFVVGLKRKI EVWHVPSTPD TNEDGDLEFA PFVRHHTHMQ HFDDVRHLEW S SDSRFFLS ASKDLTARIW SLDTEEGFVP TVLSGHRQGV VGAYFSKDQE TIYTVSKDGA VFEWKYVAKP GHEDDEMVDD ED MQWRIVN KHFFMQNAAT LRCAAYHAES NLLVAGFSNG IFGLYEMPDF NLIHTLSISQ NEIDFVTINK SGEWLAFGAS KLG QLLVWE WQSESYILKQ QGHFDAMNSL VYSPDGQRIV TAADDGKIKV WDVESGFCIV TFTEHTSGVT ACEFAKKGSV LFTA SLDGS VRAWDLIRYR NFRTFTAPER LSFTCMAVDP SGEVIAAGSI DSFDIHIWSV QTGQLLDRLS GHEGPVSSLA FAPDG SVLV SGSWDRTARI WSIFSRTQTS EPLQLQSDVL DVAFRPDSKQ IAISTLDGQL TFWSVSEAQQ VSGVDGRRDV SGGRRI TDR RTAANVAGTK NFNTIRYSMD GTCLLAGGNS KYICLYSTTT MVLLKKFTVS VNLSLSGTQE FLNSKLMTEA GPVGLLD DQ GEASDLEDRI DRSLPGSKRG DPGARKKFPE VRVSGVAFSP TGNSFCAAST EGLLVYSLDN TVQFDPFDLN MEITPAST L AVLEKEKDYL KALVMAFRLN EAGLITRVYQ AIPYTDIGLV VEQFPTVYVP RLLRFVAAQT EQSPHMEFCL LWIRALIDK HGPWLAANRG KVDVELRVVA RAVAKMRDEI RRLADENVYM VDYLLNQAKS KSNNRAVVGD AEEEWGGLDD FGVKALPSSK PETTLDDIM QDDVAESEEE WIGLE

UniProtKB: Periodic tryptophan protein 2-like protein

Macromolecule #2: Utp3

• Macromolecule: Name: Utp3 / type: protein_or_peptide / ID: 2 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 73.214633 KDa

Sequence

String:

MAKKRKATRP AEPQGPKEID PKDARLTVNN YMDVADSEDE YWYKKDRLDI DSDDEPRSKR LKRQDKEDAF LEQSDEEIFD DELSSEEEE EDDEDERRAP TKKDGKKGAA LDDDDDAELL GLGKKKDDDE IRDEGWWGSS KKEYYNADAI ETEQDALEEE K EARRLQAK KLAKMQEADF AFDEAEWLAT KDEKTGGDEE VVTEVLKEVE VTSDMGPEER YNLLQARYPE FDYLVEEFRE LR PLLETLQ KEAEGKPAKS LPVVKAWVLG CYVAALASYF AILTSPTRDG DESKGIMNPS ELRDHEVMQT LMECREAWLK VKS LRPAKG AVSAHGMLSP PEEGEEAGSD VDMLDDHAVQ KPKKAKKLSK EEIKANKKKK EEEAKKAKAV EQSLAELTSL LQTT KKAAV KASVASKAMS TAATSGADSG MDDNRSDFGE EEELDARTAA EKAKRKKSLR FYTSQIVQKA NKRQGAGRDA GGDMD IPYR ERLKDRQARL NAEAERRGKR DSKFGADLGG DSSDDEDAKA RQVRDDEDAY YNEVVQAAAK KRADKQARFE ALAAAR KGD RVVEEETIGP DGKRQITWQI QKNKGLTPNR KKEQRNPRVK KRKKYEEKQK KLRSVKAVYK GGEGPGGYQG ELSGIKT NL VKSVKL

UniProtKB: Sas10 C-terminal domain-containing protein

Macromolecule #3: Utp6

• Macromolecule: Name: Utp6 / type: protein_or_peptide / ID: 3 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 46.924773 KDa

Sequence

String:

MAWVADKARF YLERAAPELR EWEEKEIFTK DEIRNLVAKR SDFEHLVLAP GTKPTDFLNY VNWERSLDRL RAKRCARLNI RSVTSHASQ ARTFGIFERA VLKHPGSIEL WLAYLEFAAQ VKATKRWRRI MTRALRLHPM NASLWTLAGR RAAQNGDMQR A RAHFLRGC RFCTREPTLW LEYARCEMDW LARMEAKKQG QGVRKGVNAL EAIKATEGQE EGDIIPIGED TEDDSGDEDG LI LPDPDAE GTDGTKKAAK PVFDAEQTKK LEQSPALSGA IPIAVFDVAR KQPFWGPAAA EKFFDVFAKF GHLSCHERII SHV VTTMQE LFPNHPCTWS VHIRQPLVGV DVLTPAFPKA LRESLARLKA ALQSTTDRKA LATKMVAWMD GILAIEKLDA AIRT VLEHT KRSLEESPS

UniProtKB: U3 snoRNP protein

Macromolecule #4: Utp7

• Macromolecule: Name: Utp7 / type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 63.629379 KDa

Sequence

String:

MDTSEAVDLA PAPAKQGRQA NGAHSIANAR TEFRSKAELD RIRRYKQAQK KYGRGPRVDI KSVRDKKLRR TLTNLENKYK TAALKAKEA EILLENQTGF LEPEGELERT YKVRQDEIVK EVAVEVAQKK FELKLTELGP YTCEYSRNGR DLILAGRKGH V ATMDWREG KLGCELQLGE TVRDARFLHN NQFFAVAQKK YVYIYDHNGV EIHCLRKHVE VSHMEFLPYH FLLATLSISG QL KYQDTST GQIVAEIATK HGTPVSLTQN PYNAILHIGQ QNGTVTLWSP NSTDPLVKLL AHRGPVRSLA VDREGRYMVS TGQ DNKMCI WDIRNFKEAV NSYFTRAPAT SVAISDTGLT AVGWGTHTTI WKGLFNKERP VQVKVDSPYM TWGGQGQVVE RVRW CPFED ILGIGHNEGF SSIIVPGAGE ANYDALEVNP FETKKQRQEG EVKALLNKLQ PEMIALDPNF IGNLDLRSEK QRQAE RDLD QPAQDIVEEL RKKARGRNTA LKKYLRKQRK KNIIDEKRLK AEELYRQMQE KRDGQTKEKQ AEVGPALARF VRKE

UniProtKB: BING4 C-terminal domain-containing protein

Macromolecule #5: U3 small nucleolar RNA-associated protein 11

• Macromolecule: Name: U3 small nucleolar RNA-associated protein 11 / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 31.37965 KDa

Sequence

String:

MSSLRHAIQR RAHKERAQPL ERQRLGILEK KKDYRLRARD YKKKQAVLKS LRQKAAERNE DEFYFGMMSR KGPGSALTRG KGFTGTVDG DRGNKALSVE TVRLLKTQDL GYVRTMRNIA AKELKELEER YVLAGGADQP VEEFNSDEDE EESGSKQAKP K KIVFFEGV EERQQALEKQ KADEEMKDYD EEEDGYDFDD EEEMTEKEKE ERRKQLVLEK LARKVKAARK KLKALADAEY EL ELQQAKM AKTATSGGFT KSGRRIKVRE RKR

UniProtKB: U3 small nucleolar RNA-associated protein 11

Macromolecule #6: Utp12

• Macromolecule: Name: Utp12 / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 107.573039 KDa

Sequence

String:

MVKSYLKFEP SKSFGVVVSS NSNLVWSSRG KAGAGAGQAI VAANEEVLVW DIKKGELLSR WRDENCKFRV TAIAQSRTDP DVFAVGYED GSIRLWDSKI ATSVVSFNGH KSAITVLAFD KTGVRLASGS KDTDIIVWDL VAEVGQYKLR GHKDQVTGLY F IEPDPVVR TEGEDDHAVM AVDSEPSDGF LLTTGKDSLI KLWDLSSRHC IETHVAQANG ECWALGVSPD FTGCITAGND GE ITVWALD ADALASSAQK VDLSQSVNFL QNRGTLHRSS KERAAEVVFH PLRDYFAVHG VEKSVEIWRI RNEAEIKKTL ARK KKRRRE KLKEKKAEGA DADMDETDDT DIAKAEVSDV FVQHVIVRTT GKVRSVDWAL NPGVKDLQLL VGGTNNLLEL YNIV GKERL KSKGEEPDYN KALAVELPGH RTDIRSVAIS SDDKMLASAA NGSLKIWNIK TQQCIRTFDC GYALCCAFLP GDKVV IVGT KEGELQLYDV ASASLLETVN AHDGHAVWAL QVHPDGRSVV SGGADKTAKF WDFKIVQEPV LGTTRTTHRL KLVQSR ILK VSDDILSLRF SPDARLLAVA LLDSTVKVFF NDTLKLYLNL YGHKLPVLSM DISYDSKLIV TSSADKNIRI WGLDFGD CH KALFGHQDSI LQVAFIPHNS DGNGHYFFSA SKDRTIKYWD ADKFEQIQRI DGHHGEIWAL AVSHSGRFLV SASHDKSI R VWEETDEQIF LEEEREKELE ELYEQTLTTS LEQDPDEQDA NREIAAATKQ TVETLMAGER IAEALELGMT DLNTIREWE EARQINPNIA PPQRNPIFVA LGNIPAETYV LNTLQKIKPA SLHDALLVLP FSTIPSLLTF LNLFAQRELN VPLTCRILFF VLKTHHKQI VASRTMRATL EKVRANLRAA LRRQKDEMGF NIAALKVVSM QLRDKSVREY VDETWEEKEK EKGVRKRAFA S LS

UniProtKB: Small-subunit processome Utp12 domain-containing protein

Macromolecule #7: Utp13

• Macromolecule: Name: Utp13 / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 100.430352 KDa

Sequence

String:

MATKQPAKTT FEVANVIQPI YTGGSVALEN GARILASTLG ENAILTELNT GKRLAEIQGD GEPISTLTIT PSGSHLIVCS RSLTMRIYS LAISPDYDSV EPTLVRTTKP HATPVVVLAV DRTSTLLATG AADGAIKIWD IIGGYVTHTV SGPSVLVSAL H FFEIAVTA ESQSSNKKPK KGSRKGQNDD ADEIASRFRL AWGTQDGRIR IFDLYKRTTT PVYADPKRKK EAHESNVQCI AY SPEQHAL LSGSRDKTMT LWLWRDGIWQ GTPMLRHELL ESVGFLNEGK WMYSAGTSGV LRIWDTTTHH EITKKQDAKS EGE AILSAV SLPERSLILC AQADFTLVLY RVPSPADVVS SSEGILLEPF RRISGTHDEI LDLTYILPDQ SMMAIATNSE DIRI VSVKD AQAYSEDNAE CRSGSYFGHD VALLKGHEDI VMSLDVDWSG HWIASGSKDN TARLWRVDPA NNSYTCYAVF TGHLE SVGA VALPKVVPPA NSEAFKNPLD HPPAFLISGS QDRFVQKRDI PRQLQKGGKL TSSLRRLAHD KDINALDISP NGKLFA SAS QDKTVKIWDV EKLEVQGILR GHKRGVWTVR FAPLNTPVIQ GEQGSVSGRG VVLTGSGDKT IKLWNLSDYT CIRTFEG HS HNVLKVVWLH ISRDDSITKT KVQFASAGAD TLVKVWDANT GETECTLDNH EDRLWTLAVH SKTNILASAG SDSKVTFW R DTTAETQAAA AQAALKLVEQ EQTLENYIHA GAYRDAIVLA LQLNHPGRLL NLFTNVVTTR NPDPDSLTGL KAVDDVLAK LSDEQIFQLL LRLRDWNTNA RTAPVAQRVL WALFKSHPAN KLSSLSVKGA RGHKSLNEVL DAIKVYTERH YKRIEELVDE SYLVEYTLR EMDALTPQTE ALEAGEDAVI AEA

UniProtKB: U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein

Macromolecule #8: Utp14

• Macromolecule: Name: Utp14 / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 104.741391 KDa

Sequence

String:

MPGRQAHGRP LLPSLGSSSG GGKSKKSRSK ARRSAQSKAL DAFALAAEQV PESRSKGVRL RDLDEHPSTS ASRNKRQHED DEEDDFDGF DDDEGMGRKK RARRDSGGDE DGDDVDEDME GGADGEDDSE EWHVGVTGAD EDSEIDSDEA FGESDEERFE G FVFGGSKS HKKGTKKRRN GSEDDAIDLA TALDQYESSE EGEEGEESES EEDDEESEEE DSDEEDDDPS KLDALQSMIA GF AGEDEES GGEGEAKPSG KQKLSLKDLG LVGVKDPDMK RSLRLMKKEE KATKPGSSKK LEVPLAKRQQ DRLMREAAYK KTN ETLDRW IETVKHNRRA EHLVFPLAQN AHDRGLDASE LQPITQKTSG TELEQTILAI MEESGLGPTA KPEKKETSGE AGKQ GMSKE EQKELIRQKR RERELHSREM ARLKRIKKIK SKTWRRIHRK ELLKNEEAAY QAALEAGELD SEEEREALDR RRALE RVGA RHKESKWAKL GKKAGRAVWD EDFRAGLAEM ARRKDELRKR IEGLKNGSDD SSDDSDGDED ASGDEAAERR KLLAEL EKA AAYSDDDEPH SKLFQLKFMQ RGEELRRKEN EELIAQIRRE LDSDYDGSEP DEVEIGRRTF GMGKKDKTEQ QQAQDQL AR MQAAEARKEK AAARVAAAEE TVKQEAREKA EKDEASAPST AGAWSQPKVE AGAWSKPDDE GSSKPRKAPK GRPEEIDV T DLALAGKPAK AKANGQAKSQ VQGKAHASNG QSSSSQKAST SVAITGAEED GNDSDDSDAV HLPMAIRDRA LIERAFAGD DVAAEFEKEK AEIEADDDEK EIDNTLPGWG SWVGEGVSNR EKRRHQGRFV TKVEGIKKEK RKDYKLKDVI INEKRVKKND KYLATGLPH PFESQQQYER SLRLPVGPEW MTKETFQDAT KPRVIIKQGI IAPMSKPMY

UniProtKB: Uncharacterized protein

Macromolecule #9: Utp18

• Macromolecule: Name: Utp18 / type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 69.055141 KDa

Sequence

String:

MPRSNKKKQI EDLPSDSDHF PEFPEEEAFS SLSEEEEAEE RKKPVAEKDA EEEELEKFVL GAKETFREQL FRDDFLAPAN DPTALVKAG DDEEETGHEH LDDSMLFVID TEGDSSIQVP APTKVTAEET GGDAPAWEDS DDERLTISLA GATRLRKLRI S ESEDLVSG IEYARRLRQQ YLRLYPQPDW AKEANGSKRR RRRSLDASSD SLSGSDMEVD SDGESIDAPL PLDSFLRDAN SF KVAAEDS ARSAKRRKLR PETIDIQRTR DIPDTHKAAI SSLAFHPRYP ILLSSSTSSI MYLHKLDASA YPTPNPLLTS VHV KRTDLR RAAFVGPDGG EIIFAGRRRY FHCWNLSSGL VKKVSKIQGH QKEQRTMERF RVSPCGRYMA LVASDKKGGG MLNI INVGT MQWIAQARID GRHGVADFAW WSDGNGLTIA GRDGQVTEWS MITRRTVGIW RDEGSIGGTV MALGGRNGPA ELGGD RWVA IGSNSGILNV YDRNDLIEKP PKKNESNQEE QNSSEKTKEI RIKKYPTPTR VFEQLTTSIS VVAFSPDGQL LAFGSQ HKK DALRLVHLPS CTVYRNWPTE QTPLGRVTAI AFSSKSDVLA VGNDVGRVRL WEIRG

UniProtKB: Uncharacterized protein

Macromolecule #10: Putative U3 snoRNP protein

• Macromolecule: Name: Putative U3 snoRNP protein / type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 115.122008 KDa

Sequence

String:

MPHPEPDFPL TKRQKLDAAP KASSSKRKKP GSAIFAPYRT IGLISPTGVP FTSIPLGKTT FQITTSVGRA LQTYDLKRGL NLVFVTRPQ TPSDITATHA WKERVYAAFG DPRNGEPQGL WVFQRGKKVA ELPLPSDLDQ PIKQILIFGG WIVACALTRI E VWKAATLE HYTTIFPAAS KKGDNELTGG AINMPTFLNK IFVGRKDGWV EIWNVSTGKL IYTLLPPSPD CGAVTCLQPT PA LSLLAIA YSGGPLVIQN VLTDKTVLLL EAGTDDAPVT SISFRTDGLG AGQDGRKDGV MATATSVSGD VTFWDLNKGG RIM GVLRSA HNPPSRHNIV RGGISKIEFL AGQPVIVTSG LDNSLKTWIF DESPFSPVPR ILHQRSGHAA PVRCLHFLPS DFDG AEGGN KWLLSGGKDR SLWGWSLRRD GQSAELSQGA IRKKARKMGL LAGGSHGPTT TLEDLKAPEI TCIASSLNRD GGMGA IPGK QMIWDKGDDK NRISNAELSG NTGWESVVTA HKDDPYARTW FWGRRRAGRW AFKTGDGEPV STVAISSCGT FALVGS TGG SIDMFNLQSG RHRQRFPSRL TPAQLRQLKL QQLRRLDEAN KLAHRSQQKT FAPGTGRHTN AVTGIVVDPL NRHVVSC SL DGKVKFWDFI TGNLVDEIDW APMTKIIGCR YHPGNDLIAF ACDDRSIRVV DIETKNTIRE FWGCRGDIND FCFSPDGR W IVAASQDSII RVWDLPTAHL IDAFRLEQPC TALAFSHTGE YLAGAMEGSL GVQIWTNRTL FRHVPTRQIS ESEIADVAA PTTSGEGGQG LIEAALEAEE EQAEDDGVMA PIIDQLSADM MTLSLVPRSR WQTLLHIDII KARNKPKEPP KAPEKAPFFL PPVGQNGIS SLIPQEDAKA KKEKAAANGA SRITKLDLTR QEQTFTSKLL VGGAKGDYTD FIEHLKALPP AAADLELRSL S IGNGDEAT NELLHFIRAL TSRLVARRDY ELTQAWMTVF LRLHFDLIME NEELLQALGE WREHQARERD RLSELVGYCG GV VSFLRSP RT

UniProtKB: Putative U3 snoRNP protein

Macromolecule #11: Utp24

• Macromolecule: Name: Utp24 / type: protein_or_peptide / ID: 11 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 22.135992 KDa

Sequence

String:

GVAKRTRKFA TVKRIIGKQD ERRKAEAVKK AEEEKRKKEK QAIREVPQMP SSMFFEHNEA LVPPYNVLVD TNFLSRTVGA KLPLLESAM DCLYASVNII ITSCVMAELE KLGPRYRVAL MIARDERWQR LTCDHKGTYA DDCIVDRVQK HRIYIVATND R DLKRRIRK IPGVPIMSVQ KGKYAIERLP GAPAS

Macromolecule #12: Imp3

• Macromolecule: Name: Imp3 / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 21.802396 KDa

Sequence

String:

MVRKLKYHEQ KLLKKHDFIN YKSDNNHRDH DVIRRYMIQK PEDYHKYNRL CGSLRQFAHR LSLLPPDNEV RRKHETLLLD KLYDMGILS TKAKLSAVEH NVTVSAFARR RLPVVMTRLR MAETVQAATK LIEQGHVRVG VEEVRDPAFL VTRNMEDFVT W TVGSKIKQ NIMKYRDKLD DFELL

UniProtKB: Uncharacterized protein

Macromolecule #13: Putative U3 small nucleolar ribonucleoprotein

• Macromolecule: Name: Putative U3 small nucleolar ribonucleoprotein / type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 34.216266 KDa

Sequence

String:

MLRKQARQRR DYLYRRALLL RDAEIAEKRA KLRAALASGK PLDPKIANDK ELRKDFDYDV SRDIAKEQGE IDIDDEYSEL SGIVDPRVL VTTSRDPSSR LMAFSKEIRL MFPTAIRLNR GNLILPDLVM SAQRERLSDI ILLHEHRGTP TAITISHFPH G PTLMASLH NVVLRADIPK SIKGTVSESY PHLIFEGFRT PLGQRVVKIL KHLFPPRDPT NNAKSGNRVI TFVNQDDCIE VR HHVYVRT NYNSVELSEV GPRFTMRPFS ITMGTLENKD ADVEWHLSQY TRTGRKKNYF

UniProtKB: U3 small nucleolar ribonucleoprotein protein IMP4

Macromolecule #14: Putative U3 small nucleolar ribonucleoprotein protein

• Macromolecule: Name: Putative U3 small nucleolar ribonucleoprotein protein / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 86.082141 KDa

Sequence

String:

MPGAPSTTSS FTSTSHTLSA LPSMPQSLSA SAADGSGSGS DGAAAAAITA FLDSTAPENR HIFLRPTPQL PAGSLALLKA ALDPLAAQI ADHQAAGIAR LRESGALSSK KRKRDGSEKE NKPAALKIRK VHVDGFETQQ VWQQARKIIT SALGEAQAVL E ELKVNGEV EEEEGEDKVI EFGEDGFEVG SSDEEESEEE GNEEADTEDS DGEGASLGDE NAMFDLEAEE DSGSEEDKSD VG EEVDGEV DGEKHSDLDG EEEGEEGEED EEDEEDDDES AEDLVEDPHG LNDGFFSIDE FNKQTQMWED QDMRAEPTAE LDD DSEDID WHADPFAVKP SKRGKKDDGD MDLDDEEDES DDEAPPVGKK ALEKMLDKDE DDEGGNLEDD LADGMGMDLT ANDI YYKDF FAPPRKKKKP GSSKKKRELE LETKRPDDAD VERAEQDVRR DLFDDLSEHE DSEDALSDAS AGDPKSRKSA HERRQ AKIA EQIRKLEAEL VAKRAWTLAG EATAADRPVN SLLGEDMEFD HVGKPVPVVT EEVSESIEEL IKRRILAGEF DEVLRR RPD MFGNPHGVRR GLVDVEDTKA KQSLAEIYEE EAVKKANPDA YVSAADEKLR RDEEEIKRMW KEISAKLDAL SSWHYKP KP PAPTLTVVSD VATVAMEDAQ PATAQGVAGG ETSMIAPQEV YAPSKDTAEK GEVVTKAGIP IAKQEMSREE KLRRRRRE K ERIRKAGGLD GGKPVSEKEK EKKETVAQLK KSGVKVINRK GEVVGLDGKK VGEKKVQSSG AYKL

UniProtKB: Putative U3 small nucleolar ribonucleoprotein protein

Macromolecule #15: Sof1

• Macromolecule: Name: Sof1 / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 50.869828 KDa

Sequence

String:

MKIKALTRSI TAQQAPGSDV QRAPRNLAPE LHPFERAREY QRALNAVKLE RMFAKPFLGQ LGNGHVQGVY SMCKDKNSLN CIASGSGDG VVKVWDLTTR DEETWRVAAH NNIVKGLTFT NDKKLLSCAT DGIKLWDPYA SPSNTTPIAT WQEGGPYTSL S FHRSANTF AASSGQGCIR IWDLEHSTAG QAIQWPSFVD TITDVCFNQV ETSVIGSVAT DRSIILFDLR TNMPVIKTVL HF ACNRIVF NPMEAMNLAV ASEDHNIYIF DARNFDKALN IQKGHVAAVM DVEFSPTGEE LVSGSYDRTI RLWRRDAGHS RDV YHTKRM QRVFRTMWTM DSKYILTGSD DGNVRLWRAN ASERSGVKAT RQRQALEYNN ALLDRYGHLP EIRRIRRHRH LPKV VKKAT EIKREELAAI KRREENERKH SNKKYEKRKS EREKAVLVKQ Q

UniProtKB: DDB1- and CUL4-associated factor 13

Macromolecule #16: Emg1

• Macromolecule: Name: Emg1 / type: protein_or_peptide / ID: 16 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 27.936164 KDa

Sequence

String:

MQSQTAGTQS LPPPALPQLV AEQHVPIPPN DKDTKRLIVV LSNASLETYK ASHGTNRNGV REEKYTLLNS DEHIGIMRKM NRDISDARP DITHQCLLTL LDSPINKAGK LQIYIQTAKG VLIEVSPTVR IPRTFKRFAG LMVQLLHRLS IKGTNTNEKL L KVIQNPIT DHLPPNCRKV TLSFDAPLVR VRDYVDTLGP NESICVFVGA MAKGPDNFAD AYVDEKISIS NYSLSASVAC SK FCHACED AWDII

UniProtKB: Nucleolar essential protein 1

Macromolecule #17: KRR1 small subunit processome component

• Macromolecule: Name: KRR1 small subunit processome component / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 37.500777 KDa

Sequence

String:

MPSTHKKDKP WDTDDIDKWK IEPFLPEHSS GPFLEESSFM TLFPKYRERY LKDCWPLVTK ALEKHGIAAT LDIVEGSMTV KTTRKTYDP AAILKARDLI KLLARSVPAP QALKILEDGM ACDIIKIRSM VRNKERFVKR RQRLLGQNGT TLKALELLTQ T YILVHGNT VSVMGGYKGL KEVRRVVEDT MNNIHPIYLI KELMIKRELA KDPALAHEDW SRYLPQFKKR TLSKRRKPFK IN DKSKKPY TPFPPAPEKS KIDLQIESGE YFLSKEAKQR AAEAERAEKA RQKKEEKKRE REKEFVPPEE DGGKKKKRKV KHG EE

UniProtKB: KRR1 small subunit processome component

Macromolecule #18: Pre-rRNA-processing protein PNO1

• Macromolecule: Name: Pre-rRNA-processing protein PNO1 / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 28.715047 KDa

Sequence

String:

MPAPTALKQP PPAPEQQAAP AITNENEDEL LIDIQQAAAT LTDPNAAEPP EETMENEMAV DEEGRPRFAP GKNIDPIRRI ETRKIPIPP HRMSALKANW TKYPPLVDHC KLQVRMNIKE KRVELRSSKY TVSNEALQMG ADFVSAFAMG FDIDDAIALL R LDSLYIQS FDIKDVRQTL GPDALSRAIG RIAGKDGKTK FAIENATKTR IVLAGSKVHI LGAFENIGMA RESIVSLVLG AQ PGKVYNN LRIIASRMKE RW

UniProtKB: Pre-rRNA-processing protein PNO1

Macromolecule #19: 40S ribosomal protein S1

• Macromolecule: Name: 40S ribosomal protein S1 / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 29.245158 KDa

Sequence

String:

MAVGKNKRLS KGKKGLKKKV QDPFTRKDWY NIKAPAPFAV RDVGKTLVNR TTGLKNANDA LKGRIFEVCL ADLQKDEDHA FRKIKLRVD EVQGKNCLTN FHGLDFTTDK LRSLVRKWQT LIEANVTVTT TDHYLLRLFA IAFTKRRPNQ IKKTTYAQSS Q IRAIRRKM VEIIQREAAS CTLHQLVSKL IPEVIGREIE KATQGIYPLQ NVHIRKVKLL KQPKFDLGAL MALHGESSEE AG QKVEREF REQVLESV

UniProtKB: Small ribosomal subunit protein eS1

Macromolecule #20: 40S ribosomal protein s5-like protein

• Macromolecule: Name: 40S ribosomal protein s5-like protein / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 23.679225 KDa

Sequence

String:

MSEGEVEVAQ PQYDVLPKEV LAEVGSVKLF NRWSYDDIEI RDISLTDYIQ IRAPVYIPHS AGRYAVKRFR KANCPIIERL TNSLMMHGR NNGKKLMAVR IVAHAFEIIH LMTDQNPIQV AVDAIVNCGP REDSTRIGSA GTVRRQAVDV SPLRRVNQAI A LLTTGARE AAFRNVKTIA ECLAEELINA AKGSSNSYAI KKKDELERVA KSNR

UniProtKB: 40S ribosomal protein s5-like protein

Macromolecule #21: 40S ribosomal protein S7

• Macromolecule: Name: 40S ribosomal protein S7 / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 23.08465 KDa

Sequence

String:

MSAPSLNKIA ANSPSRQNPS DLERAIAGAL YDLETNTADL KAALRPLQFV SAREIEVGHG KKAIVIFVPV PALQGFHRVQ QRLTRELEK KFSDRHVLIL AARRILPKPK RSARSRNTLK QKRPRSRTLT AVHDAILTDL VYPVEIVGKR LRTKEDGSKV L KVILDEKE RGGVDYRLDT YSEVYRRLTG RNVTFEFPQT TITDY

UniProtKB: 40S ribosomal protein S7

Macromolecule #22: 40S ribosomal protein s9-like protein

• Macromolecule: Name: 40S ribosomal protein s9-like protein / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 22.029836 KDa

Sequence

String:

MAPRKYSKTY KVPRRPYEAA RLDSELKLVG EYGLRNKREV WRVLLTLSKI RRAARILLTL DEKDPKRLFE GNALIRRLVR IGVLDESRM KLDYVLALKA EDFLERRLQT LVYKLGLAKS IHHARVLIRQ RHIRVGKQIV NVPSFMVRLD SQKHIDFALT S PFGGGRPG RVRRKKAKAA EGGEGGEEEE EE

UniProtKB: 40S ribosomal protein s9-like protein

Macromolecule #23: 40S ribosomal protein S13-like protein

• Macromolecule: Name: 40S ribosomal protein S13-like protein / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 16.912891 KDa

Sequence

String:

MGRLHSKGKG ISASAIPYSR NPPAWLKTTP EQVVEQICKL ARKGATPSQI GVILRDSHGI AQVKVVTGNK ILRILKSNGL APDIPEDLY FLIKKAVAVR KHLERNRKDK DSKFRLILIE SRIHRLARYY KTVGVLPPTW KYESSTASTL VA

UniProtKB: 40S ribosomal protein S13-like protein

Macromolecule #24: 40S ribosomal protein S14-like protein

• Macromolecule: Name: 40S ribosomal protein S14-like protein / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 16.071464 KDa

Sequence

String:

MPPKKTTRPA QENISLGPQV REGELVFGVA RIFASFNDTF VHVTDLSGRE TICRVTGGMK VKADRDESSP YAAMLAAQDV AARCKELGI TALHIKIRAT GGNGTKTPGP GAQSALRALA RSGMKIGRIE DVTPTPSDST RRKGGRRGRR L

UniProtKB: 40S ribosomal protein S14-like protein

Macromolecule #25: 40S ribosomal protein S16-like protein

• Macromolecule: Name: 40S ribosomal protein S16-like protein / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 15.962771 KDa

Sequence

String:

MASVQAVQVF GKKKNATAVA RCVQGKGLIK VNGKPLKLFA PEILRAKLYE PILILGTDKF ADVDIRIRVA GGGHTSQVYA VRQAIAKSI VAYYAKYVDE HSKNLLKQEL IQFDRSLLVA DPRRCEPKKF GGRGARARFQ KSYR

UniProtKB: 40S ribosomal protein S16-like protein

Macromolecule #26: 40S ribosomal protein S22-like protein

• Macromolecule: Name: 40S ribosomal protein S22-like protein / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 14.905471 KDa

Sequence

String:

MVRTSVLHDA LNSINNAEKM GKRQVMIRPS SKVIVKFLQV MQRHGYIGEF EEVDNHRSGK IVVQLNGRLN KCGVISPRYN VRLAELEKW VTKLLPARQF GYVILTTSAG IMDHEEARRK HVAGKIIGFF Y

UniProtKB: 40S ribosomal protein S22-like protein

Macromolecule #27: 40S ribosomal protein s23-like protein

• Macromolecule: Name: 40S ribosomal protein s23-like protein / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 15.934653 KDa

Sequence

String:

MSGGKPRGLN AARKLRNNRR EQRWADLQYK KRALGTAYKS SPFGGSSHAK GIVLEKVGVE AKQPNSAIRK CVRVQLIKNG KKVTAFVPN DGCLNFVDEN DEVLLAGFGR KGKAKGDIPG VRFKVVKVSG VGLLALWKEK KEKPRS

UniProtKB: 40S ribosomal protein s23-like protein

Macromolecule #28: 40S ribosomal protein S28-like protein

• Macromolecule: Name: 40S ribosomal protein S28-like protein / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 7.74198 KDa

Sequence

String:

MDSSKAPVKF VKVTRVLGRT GSRGGVTQVR VEFMDDTTRS IIRNVKGPVR ENDILVLLES EREARRLR

UniProtKB: 40S ribosomal protein S28-like protein

Macromolecule #29: Ribosomal protein s27-like protein

• Macromolecule: Name: Ribosomal protein s27-like protein / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 8.923572 KDa

Sequence

String:

MVLAVDLLNP SPASEARKHK LKTLVPAPRS FFMDVKCPGC FTITTVFSHA QTVVICQGCT NVLCQPTGGK ARLTEGCSFR RK

UniProtKB: Ribosomal protein s27-like protein

Macromolecule #30: Faf1

• Macromolecule: Name: Faf1 / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 34.576586 KDa

Sequence

String:

MPGLLGKRKS RAEEDPEAVA KAQELLRKHF EAQFKPIDLA PLPRRAIESE DEEDESSEEG SDVNSGEGDE WDGISGDEDG TESEGDESD DEPHVVQVVD YSNDSSAADG KMSKQELKVY LSSRPPDPTR KSSSSKPKPS KKSTDDSFPE DSAELLANDL A LQRLIAES HILSEAGANP SHWQSSHAAT TGTNTRAFAT GRIAKKTTDM RIQALGAKES ILTQQKMPMN MRKGIVKHQE EK EKKRRQE ARENGIVLER EVKKKKTVRK RRERPVDLPA VGRMRGAELR ISAKEAAAIA REVRGPQGRG KRRR

UniProtKB: Uncharacterized protein

Macromolecule #32: U3 small nucleolar RNA-associated protein 22

• Macromolecule: Name: U3 small nucleolar RNA-associated protein 22 / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 131.105422 KDa

Sequence

String:

MDAAPAKRRK IAHPDGNASI ALEAAQAAAT GVSRARAFVL ETEEMLDSVD LDYSEAFDGA DALLHRLKGS IETIPAHDAQ PLLDAAAKL EKKHKLKVPF PSPPPPQNSN YKVSFATPAQ FNVVGSYVAK TMVRTQSAHG IDMIVVLPES ILQEKDYLDL R YFYKRAYY LAVVAAHLQK DLKGEATLSY EYHNGNSLLP VLSVKPNGEK DEDEKKKKKG VLDYRIRIIP CAPESFFPRQ KL HLGAGLV RKHKEGEQQA NGQPATPATP FYNSTLVAES SYLQYLKLLR QTEKKCAAFR NACILGRIWL QQRGFGSDVS KGG FGYFEW AVLLALLLQG GPADTKGAAP LSPSLSSTQL FKALIQFLSV TNFAEKPCVL GQAKPDLAGF IENGPILWDS ARQL NIAFK MGPWSADLLH QHARWTRKLL ADGAVDQFQP TFILKADLPT HTYDLVARMD PEKVSEAAPD KVAHEARGRH WQVGH KVYR ILRRALSDKN MEGGERARLI HLKVSPGFSS SSWSLNEKPQ PQKAGTPIEI GVLFDPLNMA RTVDRGPSAG PSAEEK ETC EKFRRFWGEK SELRRFGGDT IRETLVWSAQ TPFDLCEEIM RYILGLHLRV GQLQDDIVFY GRSLPALLSI KPSDTAL FN VARKTFTSFE RDLRDLEDLP LRIRHVNPIC PELRHSSLKT PSFGPSKSGP RPMEVVISFE ASGKWPESLI AIQRTKIA F LLMIGRLLER FKPGEIRTHV GLDDARYETE NLAFLDVIYA SGACFRVRIQ ADLEESLLER QTKDKTTEQY LRQRASTQL ASFRRTFVHL PLHTQYITTA TTRFPALSPT IRLVKHWFSV HKLSNHFPPE LLELFVLHTF LAPYPWDVPS SPTTGFLRTL LFLARWDWR TDPLIIDTSL NGELPAQERQ AIATRLDAWR KLDPGMQHTV LFVATAHEQS GTMWTSVDGH PRPSKVVAAR M TALAKSAA RVIREQGVDL DVRRLFVPSL KEYDVLLYLN TKVLKSALRT YITVDPATEM NGGKGQEIKF KNLAPETVEP PL PVAQHPV DVLLKQLSAV YDSAAGASGT GPLVFFRSDT TATEEGDKVI GAVWNPTLVK RKWRVNLPTS YKPVAGGKDE SED EDEDED EDGSEREKER EGEGRVEVEV NREGILAEVA RIAGEVVERI EVKGL

UniProtKB: U3 small nucleolar RNA-associated protein 22

Macromolecule #33: Rrp7

• Macromolecule: Name: Rrp7 / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 36.36657 KDa

Sequence

String:

MASNIPSTIG EFSVLPVSIP PLPSFPKNVV HYLYVRRHAP KIPTPTDSRS LFVTNVPVDS TEAHLRALVT SLVGTGRFEK VTFEDESKQ EHSLEGKSII DAAQPVHAAR LLQAHIKKRK RDDEEAQEEA AARLPSTWTR PLRRSGSTAV VLLADEKSVE Q VLKAIAKV HKTKKYPVWG GDGLPDSKMP PLGPVWLKSH NRLSFPDPSM LQASVDAFST LFARREQEAA EIAKRLRNEP DE DGFVTVT RGGRNAPASR TEAEEAKRRM LEKENKKKEE LANFYRFQLR ERKKAEAAEL LKRFDEDRKK LEELRAKKGK FVP EA

UniProtKB: Uncharacterized protein

Macromolecule #34: Putative ribosomal protein

• Macromolecule: Name: Putative ribosomal protein / type: protein_or_peptide / ID: 34 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 17.826707 KDa

Sequence

String:

MSLVSGEKTN FNHILRLLNT NVDGKQKVVY ALTQIKGVGR RYSNLVCKKA DVDLKKRAGE LTSEELERLV TIIQNPLAYK IPTWFLNRQ RDIVDGKDSQ ILANGVDSKL REDLERLKKI RAHRGLRHYW GLRVRGQHTK TTGRRGRTVG VSKKKGG

UniProtKB: Putative ribosomal protein

Macromolecule #35: RNA 3'-terminal phosphate cyclase-like protein

• Macromolecule: Name: RNA 3'-terminal phosphate cyclase-like protein / type: protein_or_peptide / ID: 35 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 43.399766 KDa

Sequence

String:

MAEPKPEFLR FTGHRAFTQR LVLATLYGRP IHISKIRSSS ATNPGLAPHE ISFLRLLESV TNGSIIDVSY SGTTITYQPG LITGTVPGM NASLSSDAIE HVIPATNTRG ITYFLIPLAL LAPFSKAHLN VRFTGPGVIT SATHGARDLS IDTFRTAVLP L YGLFGIPP ARIELRVLQR SCAGPGGKGG GGIVEMRFAS QVRLPKTLHL NRRPGKVRRI RGVAYCTGVA ASHNNRMITA AR GVLNQLV SDVHIAAQYD PAPLVAEKGT TQKKKTGIGF GLSLVAETSA EGVIYAADEV APPEGGVVPE DIGEKCAYQL LDV IAQGGC VMAASAPTVL TLMAMGSEDV GRLRLGRRVV SPELLELARD LKAFGAASWG IRDAGDDEDD AEGELGDLIV SVKG TGVGN VGRKVA

UniProtKB: RNA 3'-terminal phosphate cyclase-like protein

Macromolecule #36: Bms1

• Macromolecule: Name: Bms1 / type: protein_or_peptide / ID: 36 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 134.17225 KDa

Sequence

String:

MDSQQHKPHR PSKTKEKKKK QNSGGTNPKA FAVANPGKLA RQAARSHDIK EKRLHVPLVD RLPDEPPPRL VVIVGPPGVG KTTLLKSLV RRYTKETMSD PVGPITVVTS KKQRLTFIEC PNELEAMIDM AKVADIVLLM IDGNYGFEME TMEFLNILAN T GMPGNVFG ILTHLDLFKK PSALKDAKKR LKHRLWTELY QGAHLFYLSG VLNGRYPDRE IHNLSRFLSV MKNPRPLVWR NT HPYTIID NYRDITHPTK IEEDPLCDRT IELSGYLRGT NFAAQGQRVH IAGVGDFTIS KIEELPDPCP TPAMEKAMAN LTG KKPRRR LDEKDKKLWA PMADRSGMKI SGDHIVITRE KGFTFDKDAN VERGEGEQLI VDLQGEKKLL GQTDKGVKLF AGGE QLTQI PEEDTNDTGR KTHRKARFLE DDRQNDENGV PEDEGFVSGE ESKGSDGSDI EEEFDEKRLG KMFRGDDEET QDEDV VFAD TDSELGSISG DEGVDSEESG SDEEFDSEEE EAVRWKENMM ERARALHGKR KPWRAIDLAR LMYDTTLTPA QALRRW RGE DNEKEEEEEE DIEKDEDTFF HKAKDEDDLE EDRMIPHFDY EELKTKWSNP ENIDALRRTR FSTGRPKGDG EGDSEGE GD GDDDDDFNGF DEDDEDEGDG AFEDLETGEK HGPSKEKKEE EEKPAMSLEE ERERNARRKE ELRARFEEED REGLLNDK A IARREGGLDE EFGEDQWYEM QKAMLQKQLD INKAEYAELD EHQRRQVEGY RAGKYARLVI EGVPAEFCKN FQPRMPILV GGLSATEDRF GFVQVRIKRH RWHKKILKTG DPLIFSLGWR RFQTLPIYSI WDNRTRNRML KYTPEHMHCF GTFWGPLIAP NTSFCCFQS FSASNPGFRI AATGTVLSVD ESTEIVKKLK LVGTPWKIFK NTAFIKDMFN SSLEIAKFEG AAIRTVSGIR G QIKRALSK PEGYFRATFE DKILLSDIVI LKAWYPVKPK QFYNPATNLI GWQSMRLTGE IRRAENIPTP QNPNSTYRKI ER PERHFNP LRVPKNLAAE LPFKSQIVQT KPQKKETYMQ KRAVVVGREE RKLRDLMQKL TTIRKEKIAK RKAKKEAQRE KLK KELAEI EERRREKQKK EKKEFWEREG KKRKASEEWG GGGKRRK

UniProtKB: Bms1-type G domain-containing protein

Macromolecule #37: Kre33

• Macromolecule: Name: Kre33 / type: protein_or_peptide / ID: 37 / Number of copies: 2 / Enantiomer: LEVO; EC number: Transferases; Acyltransferases; Transferring groups other than aminoacyl groups
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 119.795125 KDa

Sequence

String:

MTVQKTVDSR IPTLIRNGLQ TKKRSFFVVV GDHAKEAIVH LYYIMSSMDV RQNKSVLWAY KKELLGFTSH RKKREAKIKK EIKRGIREP NQADPFELFI SLNDIRYCYY KETDKILGNT YGMCILQDFE AITPNILART IETVEGGGLV VLLLKGMTSL K QLYTMTMD VHARYRTEAH DDVIARFNER FLLSLGSCES CLVIDDELNV LPISGGKGVK PLPPPDEDEE LSPAAKELKK IK DELEDTQ PIGSLIKLAR TVDQAKALLT FVDAIAEKTL RNTVTLTAAR GRGKSAAMGV AIAAAVAYGY SNIFITSPSP ENL KTLFEF VFKGFDALDY KDHADYTIIQ STNPEFNKAI VRVNIHRNHR QTIQYIRPQD AHVLGQAELV VIDEAAAIPL PLVK KLMGP YLVFMASTIS GYEGTGRSLS LKLIKQLREQ SRAGANPNGG NAVEVDRSTL KATKETTSVG GRSLKEITLS EPIRY AQGD NVEKWLNTLL CLDATLPRSK ISTTGCPDPS QCELLHVNRD TLFSFHPVSE KFLQQMVALY VASHYKNSPN DLQLMS DAP AHELFVLTGP IQEGRLPEPL CVIQVSLEGK ISKQSILKSL SRGQQPAGDL IPWLVSQQFQ DDEFASLSGA RIVRIAT NP DYMSMGYGSK ALQLLVDYYE GKFADLSEDA AAEVPRSIPR VTDAELSKGS LFDDIKVRDM HELPPLFSKL SERRPEKL D YVGVSYGLTQ QLHKFWKRAQ FVPVYLRQTA NDLTGEHTCV MIRPLQDGND PSWLGAFAAD FHKRFLSLLS YKFREFPSI LALTIEESAN AGAMLDPSNA PTELTKAELD QLFTPFDHKR LESYANGLLD YHVVLDLMPT IAQLYFTGRL REAVKLSGLQ QAILLALGL QRKDIDTLAT ELNLPGSQVL AIFMKIMRKV TQHFGALVSG AIAAELPDPN KTVGVSKENA MGIHDDEVVG L KFEALEQR LEDELDEGGD EALRELRKKQ RELIDSLPLD QYEIDGDDDA WKEAEKRVAS AAKSGKKVDG TLVSVPSAKA AK RKAEEMA ALRDELEKME KGKERGSKKA KKEKRR

UniProtKB: RNA cytidine acetyltransferase

Macromolecule #38: 40S ribosomal protein S4

• Macromolecule: Name: 40S ribosomal protein S4 / type: protein_or_peptide / ID: 38 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 29.800764 KDa

Sequence

String:

MARGPKKHQK RLSAPSHWLL DKLSGAYAPR PSTGPHKLRD CMPLIVFVRN RLKYALNYRE TKAIMMQRLV KVDGKVRTDI TYPAGFMDV ITIEKTGENF RLIYDTKGRF TVHRITDEEA KYKLGKVKRV QLGRGGVPFL VTHDARTIRY PDPLIKVNDT V KIDLETGK ITDFIKFDTG ALAMITGGRN MGRVGVITHR ERHDGGFGIV HLKDALDNTF ATRESNVFVI GSEKPWISLP KG KGVKLTI AEERDQRRAR ALAAAGH

UniProtKB: 40S ribosomal protein S4

Macromolecule #39: 40S ribosomal protein S6

• Macromolecule: Name: 40S ribosomal protein S6 / type: protein_or_peptide / ID: 39 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 27.490139 KDa

Sequence

String:

MKLNISHPAN GSQKLIEVED ERKLRHFYDK RMGAEVAGDP LGPEWKGYIL RITGGNDKQG FPMKQGVIAP NRVRLLLSEG HSCYRPRRD GERKRKSVRG CIVGPDLSVL ALSIVKQGEQ DIPGLTDVVH PKRLGPKRAT KIRRFFSLSK DDDVRKYVIR R EVQPKGEG KKPYTKAPRI QRLVTPQRLQ HKRHRIALKR RQQEKVKEEA AEYAQILAKR VAEAKAQKAD LRKRRASSLH K

UniProtKB: 40S ribosomal protein S6

Macromolecule #40: 40S ribosomal protein S8

• Macromolecule: Name: 40S ribosomal protein S8 / type: protein_or_peptide / ID: 40 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 23.102416 KDa

Sequence

String:

MGISRDSRHK RSHTGAKRAF YRKKRAFELG RQPANTRIGP KRIHIVRTRG GNHKYRALRL DSGNFAWGSE GCTRKTRIIG VVYHPSNNE LVRTNTLTKS AVVQIDAAPF RQWYEAHYGQ PLGRRRQQKQ GQVVEEVKKS KSVEKKQAAR FAAHGKVDPA L EKQFEAGR LYAIISSRPG QSGRADGYIL EGEELAFYQR KLHK

UniProtKB: 40S ribosomal protein S8

Macromolecule #41: 40S ribosomal protein S11-like protein

• Macromolecule: Name: 40S ribosomal protein S11-like protein / type: protein_or_peptide / ID: 41 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 18.698182 KDa

Sequence

String:

MATELTVQSE RAFLKQPHIF LNSKVKVKST RPGKGGRRWY KDVGLGFKTP KTAIEGHYID KKCPFTGMVS IRGRILTGRV VSTKMHRTI IIRREYLHYI PKYNRYEKRH KNLAAHVSPA FRVEEGDMVV VGQCRPLSKT VRFNVLRVLP RTGKSVKKFQ K F

UniProtKB: 40S ribosomal protein S11-like protein

Macromolecule #42: 40S ribosomal protein S24

• Macromolecule: Name: 40S ribosomal protein S24 / type: protein_or_peptide / ID: 42 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 15.535286 KDa

Sequence

String:

MADTDSPVTL RTRKFIRNPL LSRKQMVVDI LHPGRPNISK DELREKLATM YKAQKDQVSV FGLRTQYGGG KTTGFALIYD SPEALKKFE PRYRLVRAGL AAKVEKASRQ QRKQRKNRLK TLRGTAKVKG AKAKKEK

UniProtKB: Small ribosomal subunit protein eS24

Macromolecule #43: Ribosome biogenesis protein ENP2

• Macromolecule: Name: Ribosome biogenesis protein ENP2 / type: protein_or_peptide / ID: 43 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 75.833805 KDa

Sequence

String:

MKLTNPGPVP VYTVAGPSTA RPLPDWLLRR RKRSAKYDPE NLNNFELIQE FEFEEASNCV RVSEDGNWIM STGTYKPQFH VHNTRELSL SFSRHTNSEN VTFLLLSQDY SKSVHLQCDR TLEFHTPMGC HYSIRIPRFG RDLAYLRQSC EVLVPAVGLS S DGSGYGEV FRLDLERGQF LRPWQVDVGE DEPGSGLQGS IHAGAVNVAA VAENTHGLCA FGTSIGTVEF YDPRSKSRVA VL GNQDGEI TALDYSRDGL SLALGTSTGQ IRIFDLRNPR PLLKKDQGMG LPIKNLIHLT TPTEERKLLS ADKRIIKIWD EQS GDLWTS VEPLVDLNFV THVPDSGMIL TANEGKQMHC FFIPNLGLAP RWCHFLDNLV HEMESEKRTE TYDNYKFLTK PELK SLSLD HLIGKTNLLR PYMHGFFVHA KLYDQARLIT NPYIWEEERA KRIKEKIEKE RSSRIRGIKK VKVNQKLVEK IAERQ EKKG KPDVAAAMLQ DPRFGKLFED EEFAVDETSR EFRALNPSTK IPGAQGDQDG DVKMGDFSSE EESSEGSGSE DEREPR REN KKPEKPKEKP KKVEEPKKHE ASKPKDEVVM QIRSSKEQGG KLGDTAFGER EQKDTRASRI RTGEVVGEQV LTFIPES KK KKPQPAPETK PRTDRRSASN NALRKL

UniProtKB: Ribosome biogenesis protein ENP2

Macromolecule #44: Utp20

• Macromolecule: Name: Utp20 / type: protein_or_peptide / ID: 44 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 295.278938 KDa

Sequence

String:

MPSATSGRIL KTSRGSKKTP HQKNHRWESF SQKISKLHSL DPLRKVRRHD LDAEDLSVTT SYLRNGLDKW AELNISRPYQ AFKREINPL TESLAQILYH EDRIMDLLVE YISRHEKEAL EPLLDLVTAF AHDLGVRFEK HYPRALSLIV DLAGSMHDVE V IEWTFAAL AFLFKYLSRL LVPDLRPTYD VVAPLMGKAK HPGHIARFSA EAMSFLVKKA AAPSHKDKAL SLFIEHVKKD LE SMVGTKQ FDLYSQGIMT MFAEAMKGVG EGLHSTAPDL FSALMRAVPK EELSLPERTV WSDVCCGVIT SVIHHSNTDT FNT VESRVV DDAMACQQQV LFIRVFGTMA GVRKGTRIHD WASFAKALNQ MLVSLGTQAK QIEVMDSSRV WKHIIVNSAI VWSR APMDA LIPAMSTFQT AMTKEPWMKW YIPFCSYLAD QNAERFRGLF LKEFQKFIVA HWSQGNNEDL LCVLIPRMVE SGGLP APGS KEIFPLPQSW QDQIVSKFVR LEDTPFPESG GFGKDPETWR DKCLPKYSAR LRVLKSTTVH PSTNSRIAEV LLKKLK LAL RPSSSLPTDE ANFITSDGFH AYLRMCKAPG SIDPSLAPLL RAAAPRFCRS PSFLQALLAY EQEIKAKGKN TPESDSG AE SSHEEHEPLI NCLIANLSSP SHELRLASLQ ILEVLDFTPD SNNALSIMIQ TEEMPLNLQS VRAIGAHLRR LGLVYSHI E QDSWLARAVP SFLWGMMTVP LAPVWDDAVE AMKKVAESKH GEEVLANIAF DWLDVPSPQW SGPYKPPADD NHGPLTNFE CLNLIHLTEA AEATNQIIEE PGQDMLSTYE EGQKIIDLRS ERARSKALKA LAALPWMAER RSRKLVPHLF AFTDDSETPE EDIEEESPE SGEGSWNLAD RKDLIKVFSQ FSNPRVLYLS QKVYQALLKL LANGDIELQK LALKAILTWK SEGIKPYQEH L EYLLDEAR FKNELTVLFQ GDNKILPEHR SEVIPVLLHL LYGRAISRKG AASGRHGLHA TRLAIIRQLD VEDMGSFLDI GL GPLRAIR VVDEQGVRES VFAHEPLPPR KQVGLLNMLE AVINELGTSV EPYMDALVNS VLYCLVNACR KLGVSAEEPE SGE GGQIEN ESLYRVIRTT ALKSLSRLFQ NAPDFNWVPY RELMVKEIIS PRIEKLPVES TQGVSATWRL MATWSSLPKA APFL NVDKR ILPKIVETLS IEKAKDEVKV FALDILKNLI NLAQAPETES QFNELIKTEL LDPNTDLILK TIGGVLHGQS DIGRE LLSS AVDTVVVFAP MIEVSSHIQD MLEIATWLLN QPLRKVNPKV KGAILLILKR FIELDDLQSN QELQRKVYST ISALFG FFK DKQNRQTLAE VLDVFARREV WAQEVSDICR GLNSYVEQRL DEPDYNTRLA AFNSITKDRD KPFTLDQWMP LVHNLLY FI QQPEEFGVLS SNSADGLCKF ISAVESVWAT PDQAAWIDVV ANIILPAIYA GSRDPSETVR REILRVFGFL VSHLPQWE L VADLTCLVPE SEDSDEAFFF HIMSPAVSRQ LQALRVLEAA NDKREFRSKH ISQFFIPLFE HFIFDRPEGG DDHGLSAQA TNTIAALTLS LEWQQYRAIL RRFISYVESK PDWQKRVVRL LEKEVDALRT AVASKKPADA MEVDGEAKPR RLASTLPDQE KLGAEIVNN FLPTLLNYIH EKDETNVSAR VPVGVIIAKL LTLLPDQLLN EKLPGVLTDI CHILRSKAWE SREMARDTLS K IAGILGPE KFEFIVRELR GSLQKGYQLH VLGYTLHSIL LVAIPSFPQG SLDYCLGIIM TVIMDDIFGV TGQEKDAEDY VS SMKEVKS SKSQDSMELL AKTASITRLS ELTLPLQSLL MEKLDLRTVR KIDELLLRIT KGLLENPAAA SQEVLVFCYE VIQ EVYRSQ KPEELPKMDP RLKRFIVQKA AKKSDGAVTA KHTYKMTRFA IDILRAVMKK HDHLRTAANL IGFLPVLGDA VLAV EEEVK VSAFKMLTVI VKVPFKNNES NGLYKVAHKE AIKSIAMSSS TQSELAQAAL KLISVILRDR RDIQMREAAL DMLLS KLKD DLTEPLYRHV TFNFLRSVLD RKLETASVYD TLDHVGTVMI TNDDKDTRDL ARGAFFQFLR EYPQKRNRWE KQLKFI VAN LKYEREGGRL SVMECINLLL KKSADEFTQE VAATCFIPLV FVLANDDSDK CRLAAGELIK ETFRVADKER QSRFLTL LR GWIAQDGNMA VVKLALHAFG LYFEGREPSA KDINDLTLVY DKLVNVLGDE KALEDDWELA HVALGTLRTL VLKHPQKV L SGDATDLWAE VQALLAHSHT EVKLSAIRLL SMYLADFAKN TTKGAKLPLS GSHGLQLDTD DVTDLVRLSL GILSAPEVD EALAQEVAQV LLFLGGYLEL AGEDDEEEGD EAEEDEANDA KERAHTADVR YLFWKLASII RKERPPKPEV LVSKHVAMDL VEAFCNRVS VETIMASIKT ILRPLRNLTD PSIKPPHSLN DIFRQRYDEL KNKAQTVMEL LQRRLGSAEY TKALLAVSEM V REKRQQRS TKRKIEALTA PEKYGREKRK KFEKKKERRK IKGREARELR KLYH

UniProtKB: Uncharacterized protein

Macromolecule #45: Bfr2

• Macromolecule: Name: Bfr2 / type: protein_or_peptide / ID: 45 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 69.040602 KDa

Sequence

String:

MSTTRNRRAR LFAEFEAKPA KDFDIENEAP DQSEESGSEE SGDDLAGTEH YVEVGKSKLR QKEPLALGPE YRGTRVSRAQ LEASSEEED EENDDDEEED DEDKEEEGSE DESGSEEYDD PDKADLEADH VDDDAEISSD NALTKSDDEN LKNFVFRGSS K PRAPVQTN GRIKKRPTAA DFMSSSSQSA SEDEKENMLE EDLEMDSQDF DMDGSEEGSE LGEDGVRLFD DEAEESVEEG ES AEDDEER FEDKDDENES HEDDEEEGED VENEQSEKED GDDERAKLRR LATEGEKSIA EAMSQAARAD AEKGLAVRKQ RRA FDSILN LRIRLQKALI AANSFHVVEK AEGQDSTEAY QAAEEAAIKL WNTIASVRHH FMPESCQTKV GEKRKREIEL DTAN QEIWE TMEEVEEVVM SHRRKVLDKW SNKVKKSNAG LNTRKLVNSE GQTLVAALDE QIMSSERLIK KARTPRSCAP VQAAK KVEE DPAIYDDADF YQLLLKELVE QRSADTGLAG EGVATVRWAA LKETKTRKNV DRRASKGRKL RYTVHEKLQN FMAPED RRS WEEHAIDRLF GTLFGQKMEL KEDEEESDEE MGGIDVEEAG LRLFRS

UniProtKB: Protein BFR2

Macromolecule #46: Utp2

• Macromolecule: Name: Utp2 / type: protein_or_peptide / ID: 46 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 103.960703 KDa

Sequence

String:

MAGSQLKRLK ASLREQGLIG PQKSKKQKRQ NANDPKAQEK RLQKAEALKS IREQFNPFQF KTNARGPKFE VTTNKPTDKN GMVIKGRPE LSRARSEEKR RQTILVEMQR RNKVGGIIDR RFGEGDPNLS VEDKMIERYT QEALRAHKKK GMFDLEDDDE A RLTHMGKP LFDDDEAPKE DFSEDDLPSG DESDTTRAER RALKRQRLAE AMEGLEDEAG QPERKKTRKE IYEEIIAKSK MY KAERQAI KEENNELRME VDQELPEVQQ LLYQIKKPET EKKEAPVPII AGKEKTVVDK EYDIRLKQLA MDKRAQPAEP VKT EEEKAA EAAKKLQELE EKRLKRMRGE PVSDDEESES EEDKGKKDKK DNAVDPLNAE ESEDEFGLGK GVKYKPTATE LGLD DEDDF LIDDDLVASG SELEFDSEDF SDVESDEEEG SSESKEDEED DEFIKGILTE AEQQEAVFQQ PKQGDDENGI PYTFP CPQS HEEMLNVVKG IEVTKLPTVV QRIRALHHPK LDAKNKERLG NFSQVLIHHI AYLGDRFQPH WFPTLEQLSR HVHSLA KTF PIEVAKAYRM RIQEMEEHRP LAPTVGDLVI LTAIGTTFPT SDHFHQVCTP AMLAIARYLG QKVPAALSDF AVGIYLS IL ALQYQDFAKR YVPEMMNFLL NTLCALAPER AKSKLGNFPV HEPPAGIRIK DATNTPIRQL NCGDCLRKDE LSPAETSS L QIAILSTATA ILKSAADTWH KLPAFIESFQ PALSVAQHLL TKPNASHLPS SLTSKLNDLA SHLSRLLQLS RLSRRPLEL HHHRPLAIKT YIPKFEDDFD PDKHYDPNRE RAELAKLKAE HKRERKGALR ELRKDAQFIR REQLRIKKEK DEAYEKKFKR IIAEIQNEE GRAANEYARE KAARKRKR

UniProtKB: Nucleolar complex protein 14

Macromolecule #47: Utp4

• Macromolecule: Name: Utp4 / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 97.696523 KDa

Sequence

String:

MDIHRCRFVR YPASAINAVA FTHSALPVVS SSKKYLQKNI QVRLAIGRAN GDIEIWNPLN GGWYQEVIIP GGKDRSVDGL VWVTDPDEE MADGKIIHGK SRLFSIGYTT TITEWDLEKA RAKKHASGQH GEIWCFGVQP LPHKANAAAA QNRKLVAGTV D GNLVLYSI EDGDLKFQKT LTRTPSKKTK FVSIAFQSHN IVIVGCSNST ICAYDVRTGT MLRQMTLGTD LTGGSKNIIV WA VKCLPNG DIVSGDSTGQ VCIWDGKTYT QAQRIQSHTQ DVLCLSVSAD GSKIISGGMD RRTAVYEPMA GQSGRWSKVF HRR YHQHDV KAMASFEGKG MSVVVSGGSD ASPIVLPLRA LGKEFHRTLP HLPQHPTVLS APKARYILSW WENEIRIWHL LNSA QQFLD DPQAPLNLRK NRKFLAQVLI KGASHITSAS ISEDGTLLAA STPTDVKVFH LDPAAAQRNG QLYIKKVNMT GTGLG ATRV QISPDKRWIC WAEEGSKVMI SRVHATESAD GISYTVSVPH KLHRLRRQIP KHILLGGLGS YDRNVSQIAF SADSRM LSV ADLAGYIDTW VLRGPGEGVN GTGGEDSDGE SAASSSDSSD EKSEDIAGER WARNPKAAMI PKLSAAPVVL SFSPTPR DD GDYDLLVVTT LKQLLIFNPL RGMLSEWSRR NTYPKLPEPF RDTRDQVKGI VWQGQRAWFY GVASLFMFDL SQDFSPEK D LVETNGHKQG TKRKRGAHES GAGSKIEKHS LVPQRIRAAS APDGTKWEDI EMVDADDQKS VGVSSGVDDD DDETDGSEL QRLREENREA NSSANAEKEG PSRAKWWHTY QFRPIMGIVP IEGMMEKKLG AVEGIPPLEV ALIERPLSED DLPERYFAEG EWER

UniProtKB: Uncharacterized protein

Macromolecule #48: UTP10

• Macromolecule: Name: UTP10 / type: protein_or_peptide / ID: 48 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 198.508438 KDa

Sequence

String:

MASSLAQQLA QIAANSRSSF NVKALKASHS KSLIWEPRVA VSQTFAEIYS QCYEGFKELC HLDSRFVPFD ATLFSAQSQE VDRTQMTAE ENAALDKRVD SFLHLVGSRL RLMPAIKAVE WLIRRFRIHE FNTGTLLATF LPYHTIPAFV TLLSILPVQR I PIEYRFLD PYIKSLTPPP RAAIVQQATN RPDLLSAISR YTLDSCRAKQ EYPGLISFWG GIMAEAVNGM IDKMRSGRRA IQ LENDHLL LQQIGPVLSE AMVMKDVPGI QIASYMVVAI LAAKGSLNDN ILTAFMEQLV HGWTVDTLRP GLVCLTMLAQ HRS AKQLSG RVAKAVIKVP DLVSSLRDIS KEHQVDKLAN GLVLAFVDRL AKKGDIRTLP VINSLLLSEL LQEKQAKVAY KALL LAAHK IDDNVDADGN IRKQVGSALV RLSQAEGDVG DAIRTAIQEV DFNIEELELK LGAAIRPKLA IEEAPEPSDE AMTVR PVDQ RPSLDSTFER LSKLQPTATS CLAKDSESLF NDLCSVFLSA AVSESDLERF DATPVLSRPK APSNSFYLSF YLRVWC GPY PTLAKVAALE RVKTRLKEGD CVDKDFQAIF PYCIAALSDP AKKVRRAAAD LVAVLGSAYK SLEKSQQLWA AKDLYGK TG TTSPLDKDAL KALIRSVLIP CLEESVLHED HVVAALVGAL ESSKDSENKN ADKRHLSHSA RLSIFKFLCG HVVETPLL A VKLRLLRSLN QIRRISGTTR TDLLLPLLRW WAGLSANEAA ELAAQESVDV PAIDDAVVDV VVPNHAAGLE AFFQLVKEA IRPGLLQAIF ARIAKMWPSM KSDTKYSTAK TLFELTQDPK LNAEQSDVIT EAVEVLRKVD LTTDILHYFI DSLQDEVRLA TEGPANKRR RVSTTEPGRG VGTQSSPELQ AALSKTTFVL ELVQESTPAN HPELLPSLFT TLSDLHHLSA IVGSELGYLQ N LVLSSLLA MMPTYKDNKD LTIDASVGHG DVLATCIQKS TSPAVINSAL LLVASLARTA PDVVLQSVMP IFTFMGSSVL KQ ADDYSAH VVNQTIKEVI PPLIETFRKR GRNVVASAKD LLASFVTAYE HIPSHRKHNL FISLIQNLGP DDFLFAILAM FVD RYGATD NMITFMTQLI SSFTVETQLQ TLLKFLDLVG DLFKSKPTLS NVLLGGGSGL NGEQDIQKAA TKQLNLLPHL LSNR RLKRE IMQLAERDDM EAGKIRELYA ALLEGILTVA STVKTKKTLH SRCGDALSNL LNLLSIAEFI KSVEALLDRP NIGLR QKVL RALELRVDSE SSVDPKSREA LLAFLPQLTA VIRESDDMNY KHTAVICVDK ISEKYGKKDL DAVAAAATTI AGDYCL GQP SQSLRVMALL CLASLVDVLQ DGIVPVLPVA IPKALSYLEQ SVAEGGRDVE LHNAAYAFMT ALAQHIPYMI TGNYLDR LL ACSNASAAAN LDDEANANRM QCLQFLAKLV DARVLYTGLH QNWASAAKFG FSAISEYLQI LGIALDKHSK TVVVKNVS S LSSIFLSAMD LRRTVAAGDI ASQISAMELD EIETKTHEDA LKMVYKLNDA AFRPIFSKFV EWATTGLPKS DVTGRTYRL YVVFGFLDAF FGSLKSIVTG YASYIVDASV KALKAVDFAV PEERNLWKRV LCTLAKCFEH DQDGFWQAPA HFGAVAPVLV EQFLRAEGQ VTATNVNDVI QDVVPAVVEL AAAVESQEHY KEINTALLKH LRNGSPGVRL AVVKCQQAIT AKLGEDWLHL L PEMLPYIS ELQDDDDEVV ERENRRWIVG IEEKLGESLD SMLQ

UniProtKB: U3 small nucleolar RNA-associated protein 10

Macromolecule #49: Utp15

• Macromolecule: Name: Utp15 / type: protein_or_peptide / ID: 49 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 60.524145 KDa

Sequence

String:

MAAEVVPLPQ LKLPSGPSPI TAEQRYWRSF KKQKSHTSTA NWPISHISFP ASLGTTALVS SSLVAAAKTN DLFAVTAGPR VEIFSIRKR EPLKTIGRFD SEAHCGEIRP DGRVLVAGED TGRMQVFDVG QGTRAVILKT WHIHKQPVWV TKWSPTELTT L MSCSDDKT VRLWDLPSND PTRLFTGHTD YVRCGAFMPG SANSNLLVSG SYDETVRVWD ARAPGGAVMT FKHADPIEDV LP LPSGTTL LAASGNAISV LDLVAAKPLR LITNHQKTVT SLSLASQGRR VVSGSLDGHV KVFETTSWNV VAGAKYPSPI LSL SVITAG ASHDDRHLAV GMQSGVLSIR TRLSGPAADR ERERERVEAA MAKGPEAIAK LDAAKAKRKR AAVSNKNMDL LGES ADVII PTADPGTHPR GRRPKLKPWQ KAFRQGRYAA AVDDVLNTTA PSYDPVIALT LLTALRHRSA LREALQGRDE LSVIN ILRW AGKYVADPRY RSICVDVAFH LIDLYAEHVG GSAELATQFQ QLLAKVNREV EKAELAIVTG GMVESLMMSV EAQ

UniProtKB: U3 small nucleolar RNA-associated protein 15 C-terminal domain-containing protein

Macromolecule #50: Utp17

• Macromolecule: Name: Utp17 / type: protein_or_peptide / ID: 50 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 105.039695 KDa

Sequence

String:

MVSTMETNGD TASLKRKREP KDDPHSLQKK HRHRSRSKPQ DAATADSVAN LNSNSLAVQP IDGNSGPLQL ATTDRLASWK VSKPMGGRM SDIDPIFSQD ERHLIITYNT SIQVYSTEDS LLVRRIALPL TRTNDLDEPS ATHIVSSALS KSNPDYLWVA C SDGRIWHI NWTSGEGVDT PSTIDTKKLL DMAVDAIEVA GKVDDVLLTL NRLTKSSAQI IAYNSKMLAT KTGKLLHTYD ES PQSLRSV AGGRAIVAAA KEALHIGILK TKKLASWEEL AYRFVSFDVP DIISTFDIRP IIRMIKKGVA ELQDIDVAVG GAR GAIYVY SNLLAHLHTE ASGPLRVGTI QPRKYHWHRR AVHSVKWSGD GNYLISGGYE TVLVLWQLDT GRVDFLPHLS AAIE NIVVS PKGSAYALHL DDNSAMVLST AEMKPSMYVS GIQSLVLGDR PSKDALVRRV WRPIDEIASP LVATISPQNP SHMFL CVGN GQQATVGGGA TSTPLVQVFD ISSFQGVAKQ AIARTNPTDV NITSEGVPII EPTATKLAFS HDGKWLASID EWQPPE RDT EAYLTGSKTQ SDACKERREI YLKFWEVGAD QSLELVTRIN DAHYTKQTES IFDLASDPTS ARFATIGNDG MVRFWSP KL RKRDGLMATR PDGQPLRSWS CSRVVPLPVH ERQDDSVEIL KGIPYSGAIT FSEDGSILFA AFGPPSGALV VAIDTQTG T VRDVVSGMFK GDIRAMKSLS SCLIMLSDDL VVYDIVSDEM LASYTLKETS EAAKKLTQLA VNHQSRSFAL AAPIPNLGQ DKLKRGTKSE LLIFNIEDEE PKLVKTFSQV IISVCAVPSS SGFVVVDSAA QVWSITEGAE QAPLLKSLAD LGVDNTSNTE MEDTPDKQL LLEQAEANDD EMHDANYDLD MEDNEDTHAV VVAPQRLAEI FNAAPAFAMP PIEDVFYQVA SLFSTKPVIN A

UniProtKB: Uncharacterized protein

Macromolecule #51: Enp1

• Macromolecule: Name: Enp1 / type: protein_or_peptide / ID: 51 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 54.319605 KDa

Sequence

String:

MPKAIAASSH KRRHNPLEDD ILATGILKNR EGRPSKRANK KVAEEENYVD SKASRKILAM SRELMDEEEQ QLKNKQVTVA STAFDFDPS RMDHDEDDQE EFVNNEEWGD EDEDAGDNDN EVDAADLEIF NRFVQPTMKD DPLLTHGWDQ KPADGEEEKE E QTNLADLI LQKIAEKEAM TGGQNGGNPI EEDYEIPPKV VEVFTKIGLI LARYKSGPLP KPFKVLPTIP HWEDIIQLTR PD LWTPNAC YAATRIFVSA KPQVVQRFME MIILERVRED IHENKKLNVH LFNCLKKALY KPAGFFKGFL FPLAASGTCT LRE AQIISA VLARISIPVL HSAAAIKTLC DIAAEQASQR AECVSATNYL LKVLLEKRYA LPWQCIDALV FHFLRYASMA REGD GAPKA LPVIFHQCLL VFAQRYRNDI TEDQREALLD LLLTHGHEKI APEIRKELLA GRGRGIPVQQ PQPTFDGDDT MLVDS

UniProtKB: Bystin-like protein

Macromolecule #52: Utp5

• Macromolecule: Name: Utp5 / type: protein_or_peptide / ID: 52 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 44.663355 KDa

Sequence

String:

MSTKRKAATA IAKPVVKQNA KAPTKTRIDE SRTAVSTGLA LKPVSKHIEE PIESDSESRH SASDDEEVSG DEGQSEEKET EADSGKQKP AASEADGDAV MQDNGEASDG EPTSPTFGDL VRGTTTVDVS ASLAAQTTRH EVQRSTAPIS ATSLGTVLNQ A LRTDDSDL LESCLQTNDL LIIQNTINRM DSSLAGTLLS KLAARMHRRP GRAFGLMRWI QWTLVAHGGA LVTQPDLINR LT ELSRVLE ERSRGLSSLL ALKGKLDMLD AQLKYRKALK MAGSSRNRPS DDDESSAGEE DNADEPAVVY VEGQESLGNA LPN GRSARH EDEDEDKQVQ IGDMISDSEE DSEDDIDPEA EDDIEEIESI DDEDEVDHDD VEEDEEEEEE DSEAEDAPPA KVRR TSARL STKRK

UniProtKB: Small-subunit processome Utp12 domain-containing protein

Macromolecule #53: Utp16

• Macromolecule: Name: Utp16 / type: protein_or_peptide / ID: 53 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 40.726016 KDa

Sequence

String:

MGRRSSEKEM EVIELSSDSE QEVSATKAVV PERTSRSPSL DRLETPFFKA PGIVYKDDDA NNQEGEKFVQ PKDKQEPISQ STESDDKSL SRKHVCIEIP LPTSSELQQR KVEAAAEKTE ESSKTSADRR HITFDDSESE QFITLKEEAA SRNGLGNGSK K SEREIVQD SQDEEEDSEE SDDDAPPEEV ATGEAEAALL KAERAAAKAA EQQAAALKRK RQERDAFLKQ QAEQRKRNKK PA QLAEEDS DEEDAGPQRT LPIRSEQKKE APKLLPLELL ESDDEDSTPA SAITQKRRKL DVDPKLLVEP KNPKDKRVGS TAY RVVSNG GDPRLAPKAK KQSLNLKQAL LRRDRVAKPR GGFFVNKR

UniProtKB: Uncharacterized protein

Macromolecule #54: Utp8

• Macromolecule: Name: Utp8 / type: protein_or_peptide / ID: 54 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 102.421133 KDa

Sequence

String:

MAAKLQIHAP YVLHALPRPL DRSDGLGRYF SGEVFGQKQG GKRKKRTELA VAIDGVAVYL YDILSSQVVT SYLVSPQSCF TCPPSSLRW RPASSKTVTR YTYVSVATGD SVLAKREIRL FREETLSTGN TVVACISRTI CSDSPIVHIF TSSPRNFLTN V PGKDIPNH DLIIITANGS IFALNGETLE EKWQVSPSVL SREILSDSKL ALQVDFVQQT SAADVADGLF GGKNDLFGVF QE RIHRDGF NPDFFVVITS QSGADSANAR HLHVLALPSE REARQTGKEN VISVFVAPLA VEETCRSFQL DVRSGTLQAI SNK ALVTYQ FANGIAKLEN RLQVPGLSSY LRLSKTSVLT SATDSLSVYN PIYRSLQAAA RLEPTDDTNG HACEFVSYLA SREL AVAIR GGSLVVIQIE APKNRTAKRR AEGLLTDAIR RGISRKIAFE KRTKPEHVSD STILADAVPG SLSDPSWSEW QNKAM QADE LLQNNDIQSW EELMAEVFKV PIKPDETADA EKQTAPNPVV KLPEWEWPSS RSDYARVDRR WVVYAINKVF GWEGQL ESN TGRLTCRLPE SSVLIYLVDA GHLSTSNVKS AFKDDVREVD KVEELIGEQL PIILAEVDPT MELLVGYLSG TQLGSSE LV SSIKLLLCSL GLFEDGSRLP AVGDNTHIEQ VTGQENEVVN MELDRAEEEL QITEHYLDEH RTRGLGIAFS KLAACPAA E TVKSLRRLFK PDEVLVLLNV LRAELIKDGW TTRYLDKINA DQEDDAPPDA SIQLIADLMS RCIDAVGLSG WMAADVMLS SSRTHQDSAN FFSQFQAEIS VALEGVMEAV RLKGVIAEAA NYAKRARRAL ADSAKGKAMT VHMSAELPLG LKTDNKISTE RVRSGGEIV ARSSRQIGHF ISKRRGIYSI HRISEEMLLG AAGPTVVQEA R

UniProtKB: Uncharacterized protein CTHT_0071780

Macromolecule #55: Noc4

• Macromolecule: Name: Noc4 / type: protein_or_peptide / ID: 55 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 63.331664 KDa

Sequence

String:

MPSAVETVTK ASTKRKRQEN EDEGKKRRKS ISNGDSEAQK QHIKNLEEQI AESKKHYNNI ANLIELAQKH DEDPKWSLAA AEALCRVFV RLLAAGSLVK RKDISEKDAT IINWLRDRLS DYDGVLLSML QSKKLAVHAL VLAMAVLKAQ AQHLTDREEA I FPRSFFLE IIAVVLESPI EHLRGHFSEN FVKKYDDIRF YTFEAIKHFL TEREQSVDED VRNNVFNLLL SIEDVPESND SL ENFFIER PPKKKHPLLS LSQHKKQAQE AWLAFMHLGL SKEQRKKVLE VMSASIAPWF TKPEMLMDFL TDCYNSGGSV SLL ALSGVF YLIQERNLDY PEFYTKLYSL LDADILHSKY RSRFFRLLDT FLASTHLPAV LVASFIKRLA RLALNAPPSA IVVI VPWFY NLFKKHPLTT FMMHRVPRTK EEREKLEKDG LDDPFLPNET DPMETRAIDS CLWEIVQLQS HYHPNVATIC KIISE QFTK QAYNLEDFLD HSYGSLLEAE MTKEVKKPPV IEFMIPKHIF TKAAPEEEKK DSLLVSLWDF GSGSA

UniProtKB: CCAAT-binding factor domain-containing protein

Macromolecule #56: Nop1

• Macromolecule: Name: Nop1 / type: protein_or_peptide / ID: 56 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 32.960844 KDa

Sequence

String:

MGFERGGRGG GRGGAAARGG RGGARGGRGG PAGRGGPAGR GRGGPAGRGR GGRSGRGGKP KAKGAKAGKK VIVEPHRHKG VFVARGGKE DLLCTANLVP GESVYGEKRI SVETPGSGPD AVATKTEYRI WNPFRSKLAA GILGGLETIY MKPGSKVLYL G AASGTSVS HVADIVGPTG AVYAVEFSHR SGRDLINMAT RRTNVIPIVE DARKPMAYRM LVPMVDVIFA DVAQPDQARI VG INARLFL KQGGGLLISI KASCIDSTAP PEQVFASEVQ KLREDKFFPK EQLTLEPYER DHAMVSCVYL QKEFEG

UniProtKB: rRNA 2'-O-methyltransferase fibrillarin

Macromolecule #57: Putative nucleolar protein

• Macromolecule: Name: Putative nucleolar protein / type: protein_or_peptide / ID: 57 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 57.830699 KDa

Sequence

String:

MVVVNFLLFE SAVGFSLFEV VHQADTVGLE LPEVKDAMKT LDKFGKMVKL RSFNPWTSAA QGLEAINLIS EGIMPEYLKS ALEMNLPQT SGKKSKVVLG VADKKLAGEI TAAFPGVQCE AADTSEVVAA LLRGIRTHAN KLHKSLQEGD IGRAQLGLGH A YSRAKVKF SVHKNDNHII QGIATLDALD KSINQGAMRV REWYGWHFPE LIRIVSDNIT YAKVVLAIGN KSSLTDESVD DL ANVLNQD QDKALAIIQA AKVSMGQDIS EVDLQMVRDL ASNVTSMADY RRILAESLDK KMSEVAPNLQ VILGTPVAAR LIA HAGSLT NLAKYPASTL QILGAEKALF RALKTKSATP KYGLLYQSSF IGRAGPKVKG RISRYLANKC SIASRIDNFS EKPT RHFGE VLRQQLEQRL EWYAKGTKPM KNSEAMEKAI KAVMADDEET LPVAVDAMDI DSKSPAKEKK DKKEKKEKKE KKEKK KEDK EEKKKDKKRK SLGGEDVEMA DADVGENKKK KKRKSEIAE

UniProtKB: Nucleolar protein 56

Macromolecule #58: Nop58

• Macromolecule: Name: Nop58 / type: protein_or_peptide / ID: 58 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 64.292113 KDa

Sequence

String:

MPLFILTETS AGYALFKAAD KKLLDSDNVS ERLSTLDKII KEIKYKEFAK FDSAAIAVEE ASGILEGKVT PKLASLLNEL KDEKKVTLA VHDTKLSNSI TKLPGINIKP ISGSMTDDLF RAIRQHLYNL IPGMEPSNFD EMNLGLAHSL SRHKLKFSPE K VDVMIVHA VALLDELDKE LNVMAMRVKE WYGWHFPELG KILPDNLSYA RVVLALGLRT NAPNADLSEI LPPEIEAAVK AA ADISMGT EISTEDYENI KLLAVQVVER SEYRRQLAEY LQNRMKAISP NMTELIGALV GARLIAHSGS LVNLAKNPGS TIQ ILGAEK ALFRALKTKH ATPKYGIIYH ASLVGQASGP NKGKIARQLA AKIALSVRTD AFEDFPENAD DETRAAVGIQ ARAK LENNL RLLEGKPLNK GVALGPNGIP VGMPAKWDVK EARKYNIEAD GLATTTSKES SEQPKRPLIE EVPEVEMKDA SASDK KDKK EKKKEKKEVA SSKITEADYE RIAKELGMSL SKFTKKLEKG KIKIKPDGSV EVKGKDGEDA EAETPVKSKS SKRKHE PEE ETPAKEEKHK KKKKKSSKE

UniProtKB: Nucleolar protein 58

Macromolecule #59: Snu13

• Macromolecule: Name: Snu13 / type: protein_or_peptide / ID: 59 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 13.831854 KDa

Sequence

String:

MSNNESAAWP KAEDPALVQE LLDCVQQASH YRQLKKGANE TTKSVNRGTS ELVILAADTQ PLSIVLHIPL ICEEKNVPYV YVPSKVALG RACGVSRAVI AVSLTSNEAS DLNSKIRALR DKVERLAM

UniProtKB: H/ACA ribonucleoprotein complex subunit 2

Macromolecule #60: Rrp9

• Macromolecule: Name: Rrp9 / type: protein_or_peptide / ID: 60 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 69.610438 KDa

Sequence

String:

MSSFFTAPAS EKKRKRAATA DAPKKRLATT KSSSKSGSKA PTKAAAPASK KKAIERDESI SGSDLDSDLS GDDEFIERRS SDAGSGDES EKEGETAAEK RLRLAQRYLE KTRKEVEQLD EYAFDAEEID RDLLAERLKE DVAEAKGKVY RRLASELAFD K ATYTQFRW NSGTVTSVAV CPPYAYTTTK DGYLTKWKLQ DLPKNQWPQT TKKKPKKPPA PPKKRPERIC FAKADARKAN DK TYQGHLK APLVVKASQD GKFVVTGGAD KRLVVYNAAD LKPIKAFTQH RDAVTGLAFR RGTNQLYSCS KDRTVKVWSL DEL AYVETL FGHQDEILDI DALGQERCVS VGARDRTARY WKVPEESQLV FRGGGEGGSS NTKKHKLPPG MDPASAAHEG SMDR VAMID DDMFVTGSDN GDLALWSIQR KKPLHVIARA HGLEPPIKLE DYSADEIPDP SIIPAPQPRG ITALRTLPYS DLIFS GSWD GCIRVWRLSE DKRKLEAVGI LGVGSETCEN STNISNGATS NGESSSTSSS TTLAAQSSSS SSPPPSQPKD LVRGIV NDI ALFERGERGR DGLCVVVVTG KEMRFGRWKY MKEGRCGAVI FEVPKVEKKN KRKNEDKKEE VNGVYKE

UniProtKB: Ribosomal RNA-processing protein

Macromolecule #61: Fcf2

• Macromolecule: Name: Fcf2 / type: protein_or_peptide / ID: 61 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 22.569129 KDa

Sequence

String:

MATTLGLPDE EIDRLLAEAE ARLAGSGDAD AGAIALAKPA ASKPLTVAAP AAPKAGEQTV PQVKKAEELS VRVPQLPQKK KGPPDTLSD WYNIPRTNLT PELKRDLQLL RMRDVVAMGK QFFKKDNRKD FVPEYCQVGT IIAGATDGVS GRLTRKERKR T IVEEVLSS DSVSKYKRKY HEIQEHKKSG RKGYYKKLMA ARKRK

UniProtKB: Fcf2 pre-rRNA processing C-terminal domain-containing protein

Macromolecule #63: 40S ribosomal protein S19-like protein

• Macromolecule: Name: 40S ribosomal protein S19-like protein / type: protein_or_peptide / ID: 63 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 17.151332 KDa

Sequence

String:

MPGGVTVRDV DAHKFVAAYA AFLKRQGKLP VPGWVDTVKT GNAKELPPQD IDWWYIRAAS VARHVYLRKT VGVGRLRKVH GSAKNRGTR PSHHVDASGS VDRKIMQALE KIQVLEKDEE RGGRRITQQG QRDLDRIAQT VAEADQESEA EEEE

UniProtKB: 40S ribosomal protein S19-like protein

Macromolecule #31: 35S ribosomal RNA

• Macromolecule: Name: 35S ribosomal RNA / type: rna / ID: 31 / Number of copies: 1
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 599.293312 KDa

Sequence

String:

GGGGGGAUGU CCGGGUCGCC CUGGGCACCU CUCCCGGCAG CCUUCGCGGG CAGCCGUAGU CCCGGUUCAU ACGGGCUCUG UGGGUGGGG GAAUUCAGGA GGGGAAAGCU UAGGCGCACG AUAGUUACCU GGUUGAUUCU GCCAGUAGUC AUAUGCUUGU C UCAAAGAU UAAGCCAUGC AUGUCUAAGU AUAAGCAAUU AUACAGCGAA ACUGCGAAUG GCUCAUUAAA UCAGUUAUCG UU UAUUUGA UAGUACCUUA CUACAUGGAU AACCGUGGUA AUUCUAGAGC UAAUACAUGC UGAAAAUCCC GACUUCGGAA GGG AUGUAU UUAUUAGAUU AAAAACCAAU GCCCUUCGGG GCUUUCUGGU GAUUCAUAAU AACUUCUCGA AUCGCACGGC CUUG CGCCG GCGAUGGUUC AUUCAAAUUU CUGCCCUAUC AACUUUCGAC GGCUGGGUAU UGGCCAGCCG UGGUGACAAC GGGUA ACGG AGGGUUAGGG CUCGACCCCG GAGAAGGAGC CUGAGAAACG GCUACUACAU CCAAGGAAGG CAGCAGGCGC GCAAAU UAC CCAAUCCCGA CACGGGGAGG UAGUGACAAU AAAUACUGAU ACAGGGCUCU UUCGGGUCUU GUAAUUGGAA UGAGUAC AA UUUAAAUCCC UUAACGAGGA ACAAUUGGAG GGCAAGUCUG GUGCCAGCAG CCGCGGUAAU UCCAGCUCCA AUAGCGUA U AUUAAAGUUG UUGAGGUUAA AAAGCUCGUA GUUGAACCUU GGGCCUAGCC CGCCGGUCCG CCUCACCGCG UGCACUGGC UGGGCUGGGC CUUUCCUUCU GGAGAACCGC AUGCCCUUCA CUGGGUGUGU CGGGGAACCA GGACUUUUAC UCUGAACAAA UUAGAUCGC UUAAAGAAGG CCUAUGCUUG AAUACAUUAG CAUGGAAUAA UAGAAUAGGA CGUGUGGUUC UAUUUUGUUG G UUUCUAGG ACCGCCGUAA UGAUUAAUAG GGACAGUCGG GGGCGUCAGU AUUCAAUUGU CAGAGGUGAA AUUCUUGGAU UU AUUGAAG ACUAACAACU GCGAAAGCAU UCGCCAAGGA UGUUUUCAUU AAUCAGGAAC GAAAGUUAGG GGAUCGAAGA CGA UCAGAU ACCGUCGUAG UCUUAACCAU AAACUAUGCC GAUUAGGGAU CGGACGGCGU UUAUUUUUGA CCCGUUCGGC ACCU UACGA UAAAUCAAAA UGUUUGGGCU CCUGGGGGAG UAUGGUCGCA AGGCUGAAAC UUAAAGAAAU UGACGGAAGG GCACC ACCA GGGGUGGAGC CUGCGGCUUA AUUUGACUCA ACACGGGGAA ACUCACCAGG UCCAGACACG AUGAGGAUUG ACAGAU UGA GAGCUCUUUC UUGAUUUCGU GGGUGGUGGU GCAUGGCCGU UCUUAGUUGG UGGAGUGAUU UGUCUGCUUA AUUGCGA UA ACGAACGAGA CCUUAACCUG CUAAAUAGCC CGUAUUGCCU UGGCAGUACG CCGGCUUCUU AGAGGGACUA UCGGCUCA A GCCGAUGGAA GUUUGAGGCA AUAACAGGUC UGUGAUGCCC UUAGAUGUUC UGGGCCGCAC GCGCGCUACA CUGACAGAG CCAGCGAGUA CUCCCUUGGC CGAGAGGCCC GGGUAAUCUU GUUAAACUCU GUCGUGCUGG GGAUAGAGCA UUGCAAUUAU UGCUCUUCA ACGAGGAAUC CCUAGUAAGC GCAAGUCAUC AGCUUGCGUU GAUUACGUCC CUGCCCUUUG UACACACCGC C CGUCGCUA CUACCGAUCG GAAAGUUAUC CAAACUCGGU CGUUUAGAGG AAGUAAAAGU CGUAACAAGG UCUCCGUAGG UG AACCUGC GGAGGGAUCA UU

Macromolecule #62: U3 snoRNA

• Macromolecule: Name: U3 snoRNA / type: rna / ID: 62 / Number of copies: 1
• Source (natural): Organism: Chaetomium thermophilum (fungus)
• Molecular weight: Theoretical: 74.578875 KDa

Sequence

String:

AGCGACAAUA CUUCAGAGAA UCAUUUCUAU AGUAGUUGUC CUCUCUUGUG UUUCCUAAAG GAGCCACAGA UCCCACCCGG GUUGAUGAA CGAGAUCCUC GGCGCCAGUG AGGUCCAUUU UUACUCUCGC UCUACCUGCA AAGGUGGCGG UCGCGUGCCU C GUCUCGCG GCUGUAUAGA GAGUGGCGAU GAUCUGUACC CCGCGGGGUG GGUGUCGAUG GAAGUCUGAC CGGC

Macromolecule #64: ZINC ION

• Macromolecule: Name: ZINC ION / type: ligand / ID: 64 / Number of copies: 2 / Formula: ZN
• Molecular weight: Theoretical: 65.409 Da

Experimental details

Structure determination

• Method: cryo EM
• Processing: single particle reconstruction
• Aggregation state: particle

Sample preparation

• Buffer: pH: 7.5
• Vitrification: Cryogen name: ETHANE

Electron microscopy

• Microscope: FEI TITAN KRIOS
• Image recording: Film or detector model: FEI FALCON II (4k x 4k) / Average electron dose: 28.0 e/Ų
• Electron beam: Acceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
• Electron optics: Illumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD
• Experimental equipment: Model: Titan Krios / Image courtesy: FEI Company

Image processing

• Startup model: Type of model: EMDB MAP
• Final reconstruction: Applied symmetry - Point group: C₁ (asymmetric) / Resolution.type: BY AUTHOR / Resolution: 7.1 Å / Resolution method: FSC 0.143 CUT-OFF / Software - Name: RELION / Number images used: 9041
• Initial angle assignment: Type: OTHER / Software - Name: RELION
• Final angle assignment: Type: OTHER / Software - Name: RELION