Entry Database : PDB / ID : 5tqs Structure visualization Downloads & linksTitle Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the receptor tyrosine kinase ErbB2 Components1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Receptor protein-tyrosine kinase DetailsKeywords HYDROLASE / SH2 / phospholipase / phosphopeptideFunction / homology Function and homology informationFunction Domain/homology Component
calcium-dependent phospholipase C activity / negative regulation of immature T cell proliferation in thymus / phosphoinositide phospholipase C / ERBB3:ERBB2 complex / ERBB2-ERBB4 signaling pathway / phospholipid catabolic process / GRB7 events in ERBB2 signaling / immature T cell proliferation in thymus / RNA polymerase I core binding / phosphatidylinositol metabolic process ... calcium-dependent phospholipase C activity / negative regulation of immature T cell proliferation in thymus / phosphoinositide phospholipase C / ERBB3:ERBB2 complex / ERBB2-ERBB4 signaling pathway / phospholipid catabolic process / GRB7 events in ERBB2 signaling / immature T cell proliferation in thymus / RNA polymerase I core binding / phosphatidylinositol metabolic process / phosphatidylinositol phospholipase C activity / COP9 signalosome / regulation of microtubule-based process / ErbB-3 class receptor binding / semaphorin receptor complex / Sema4D induced cell migration and growth-cone collapse / motor neuron axon guidance / neurotransmitter receptor localization to postsynaptic specialization membrane / PLCG1 events in ERBB2 signaling / neuromuscular junction development / ERBB2-EGFR signaling pathway / ERBB2 Activates PTK6 Signaling / positive regulation of Rho protein signal transduction / Drug-mediated inhibition of ERBB2 signaling / Resistance of ERBB2 KD mutants to trastuzumab / Resistance of ERBB2 KD mutants to sapitinib / Resistance of ERBB2 KD mutants to tesevatinib / Resistance of ERBB2 KD mutants to neratinib / Resistance of ERBB2 KD mutants to osimertinib / Resistance of ERBB2 KD mutants to afatinib / Resistance of ERBB2 KD mutants to AEE788 / Resistance of ERBB2 KD mutants to lapatinib / Drug resistance in ERBB2 TMD/JMD mutants / enzyme-linked receptor protein signaling pathway / positive regulation of transcription by RNA polymerase I / ERBB2-ERBB3 signaling pathway / positive regulation of epithelial cell migration / oligodendrocyte differentiation / ERBB2 Regulates Cell Motility / phosphatidylinositol-mediated signaling / semaphorin-plexin signaling pathway / PI3K events in ERBB2 signaling / positive regulation of cell adhesion / positive regulation of protein targeting to membrane / cellular response to vascular endothelial growth factor stimulus / regulation of angiogenesis / coreceptor activity / Schwann cell development / release of sequestered calcium ion into cytosol / Signaling by ERBB2 / cellular response to epidermal growth factor stimulus / ruffle / cell surface receptor protein tyrosine kinase signaling pathway / myelination / GRB2 events in ERBB2 signaling / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / Downregulation of ERBB2:ERBB3 signaling / transmembrane receptor protein tyrosine kinase activity / SHC1 events in ERBB2 signaling / Constitutive Signaling by Overexpressed ERBB2 / phosphatidylinositol 3-kinase/protein kinase B signal transduction / neurogenesis / regulation of ERK1 and ERK2 cascade / guanyl-nucleotide exchange factor activity / basal plasma membrane / positive regulation of epithelial cell proliferation / positive regulation of translation / Signaling by ERBB2 TMD/JMD mutants / positive regulation of MAP kinase activity / wound healing / Signaling by ERBB2 ECD mutants / neuromuscular junction / neuron differentiation / Signaling by ERBB2 KD Mutants / epidermal growth factor receptor signaling pathway / receptor protein-tyrosine kinase / receptor tyrosine kinase binding / cellular response to growth factor stimulus / Downregulation of ERBB2 signaling / ruffle membrane / peptidyl-tyrosine phosphorylation / transmembrane signaling receptor activity / Constitutive Signaling by Aberrant PI3K in Cancer / lamellipodium / PIP3 activates AKT signaling / myelin sheath / presynaptic membrane / heart development / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / positive regulation of cell growth / basolateral plasma membrane / protein tyrosine kinase activity / in utero embryonic development / positive regulation of MAPK cascade / membrane => GO:0016020 / cell surface receptor signaling pathway / early endosome / receptor complex / endosome membrane Similarity search - Function 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase C, X domain ... 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase C, X domain / Phosphatidylinositol-specific phospholipase C, X domain / Phospholipase C, catalytic domain (part); domain X / Phosphatidylinositol-specific phospholipase X-box domain profile. / PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily / : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / SH2 domain / SHC Adaptor Protein / C2 domain / Protein kinase C conserved region 2 (CalB) / C2 domain / C2 domain profile. / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain / Furin-like repeat / Furin-like repeats / PH domain / C2 domain superfamily / Growth factor receptor cysteine-rich domain superfamily / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / SH2 domain superfamily / EF-hand calcium-binding domain profile. / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / EF-hand domain / EF-hand domain pair / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / PH-like domain superfamily / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homology Receptor tyrosine-protein kinase erbB-2 / Receptor tyrosine-protein kinase erbB-2 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Similarity search - ComponentBiological species Bos taurus (cattle)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 1.876 Å DetailsAuthors Wuttke, D.S. / McKercher, M.A. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Science Foundation (NSF, United States) MCB1121842 United States
CitationJournal : Biochemistry / Year : 2017Title : Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein.Authors : McKercher, M.A. / Guan, X. / Tan, Z. / Wuttke, D.S. History Deposition Oct 24, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 19, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Apr 26, 2017 Group : Database referencesRevision 1.2 May 10, 2017 Group : Database referencesRevision 1.3 Sep 27, 2017 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Nov 27, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.5 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accessionRevision 1.6 Nov 15, 2023 Group : Data collection / Category : chem_comp_atom / chem_comp_bond / Item : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2
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