Entry Database : PDB / ID : 5otn Structure visualization Downloads & linksTitle Crystal structure of zebrafish MTH1 in complex with O6-methyl-dGMP ComponentsNudix (Nucleoside diphosphate linked moiety X)-type motif 1 Details Keywords HYDROLASE / MTH1 / Inhibitor / Complex / NUDIX / Methylated nucleotide / O6-methyl-dGMP / zebrafishFunction / homology Function and homology informationFunction Domain/homology Component
purine deoxyribonucleotide metabolic process / Phosphate bond hydrolysis by NUDT proteins / nucleoside triphosphate diphosphatase activity / 2-hydroxy-dATP diphosphatase / hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides / 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity / DNA protection / phosphatase activity / Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides / mitochondrial matrix ... purine deoxyribonucleotide metabolic process / Phosphate bond hydrolysis by NUDT proteins / nucleoside triphosphate diphosphatase activity / 2-hydroxy-dATP diphosphatase / hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides / 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity / DNA protection / phosphatase activity / Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides / mitochondrial matrix / RNA binding / nucleus / metal ion binding / cytosol / cytoplasm Similarity search - Function Oxidized purine nucleoside triphosphate / NUDIX hydrolase / NUDIX hydrolase, conserved site / Nudix box signature. / Nucleoside Triphosphate Pyrophosphohydrolase / Nucleoside Triphosphate Pyrophosphohydrolase / NUDIX domain / Nudix hydrolase domain profile. / NUDIX hydrolase domain / NUDIX hydrolase-like domain superfamily ... Oxidized purine nucleoside triphosphate / NUDIX hydrolase / NUDIX hydrolase, conserved site / Nudix box signature. / Nucleoside Triphosphate Pyrophosphohydrolase / Nucleoside Triphosphate Pyrophosphohydrolase / NUDIX domain / Nudix hydrolase domain profile. / NUDIX hydrolase domain / NUDIX hydrolase-like domain superfamily / Alpha-Beta Complex / Alpha Beta Similarity search - Domain/homologyBiological species Danio rerio (zebrafish)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 0.99 Å DetailsAuthors Gustafsson, R. / Henriksson, L. / Jemth, A.-S. / Brautigam, L. / Carreras Puigvert, J. / Homan, E. / Warpman Berglund, U. / Helleday, T. / Stenmark, P. Funding support Sweden, 9items Details Hide detailsOrganization Grant number Country Swedish Research Council Sweden Knut and Alice Wallenberg Foundation Sweden Wenner-Gren Foundation Sweden Ake Wiberg Foundation Sweden Swedish Foundation for Strategic Research Sweden Swedish Pain Relief Foundation Sweden Torsten and Ragnar Soderberg Foundation Sweden Swedish Childrens Cancer Foundation Sweden Swedish Cancer Society Sweden
CitationJournal : Nucleic Acids Res. / Year : 2018Title : MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.Authors : Jemth, A.S. / Gustafsson, R. / Brautigam, L. / Henriksson, L. / Vallin, K.S.A. / Sarno, A. / Almlof, I. / Homan, E. / Rasti, A. / Warpman Berglund, U. / Stenmark, P. / Helleday, T. History Deposition Aug 22, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Sep 5, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Oct 17, 2018 Group : Data collection / Database references / Category : citationItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.title / _citation.year Revision 1.2 Oct 24, 2018 Group : Data collection / Database references / Category : citation / citation_author / Item : _citation.pdbx_database_id_PubMed / _citation.titleRevision 1.3 Nov 28, 2018 Group : Data collection / Database references / Category : citation / pdbx_database_procItem : _citation.journal_volume / _citation.page_first / _citation.page_lastRevision 1.4 Jan 17, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_symmetry
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