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-Structure paper
Title | MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP. |
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Journal, issue, pages | Nucleic Acids Res., Vol. 46, Page 10888-10904, Year 2018 |
Publish date | Aug 22, 2017 (structure data deposition date) |
Authors | Jemth, A.S. / Gustafsson, R. / Brautigam, L. / Henriksson, L. / Vallin, K.S.A. / Sarno, A. / Almlof, I. / Homan, E. / Rasti, A. / Warpman Berglund, U. ...Jemth, A.S. / Gustafsson, R. / Brautigam, L. / Henriksson, L. / Vallin, K.S.A. / Sarno, A. / Almlof, I. / Homan, E. / Rasti, A. / Warpman Berglund, U. / Stenmark, P. / Helleday, T. |
External links | Nucleic Acids Res. / PubMed:30304478 |
Methods | X-ray diffraction |
Resolution | 0.99 - 1.8 Å |
Structure data | PDB-5otm: PDB-5otn: |
Chemicals | ChemComp-SO4: ChemComp-ACT: ChemComp-6OG: ChemComp-HOH: ChemComp-GOL: ChemComp-CA: ChemComp-EDO: ChemComp-CL: |
Source |
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Keywords | HYDROLASE / MTH1 / Inhibitor / Complex / NUDIX / Methylated nucleotide / O6-methyl-dGMP / zebrafish |