Entry Database : PDB / ID : 5hzx Structure visualization Downloads & linksTitle Crystal structure of zebrafish MTH1 in complex with TH588 ComponentsNudix (Nucleoside diphosphate linked moiety X)-type motif 1 Details Keywords HYDROLASE / Inhibitor / Complex / MTH1 / TH588Function / homology Function and homology informationBiological species Danio rerio (zebrafish)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.9 Å DetailsAuthors Narwal, M. / Gustafsson, R. / Brautigam, L. / Pudelko, L. / Jemth, A.-S. / Gad, H. / Karsten, S. / Carreras-Puigvert, J. / Homan, E. / Berndt, C. ...Narwal, M. / Gustafsson, R. / Brautigam, L. / Pudelko, L. / Jemth, A.-S. / Gad, H. / Karsten, S. / Carreras-Puigvert, J. / Homan, E. / Berndt, C. / Berglund, U.W. / Helleday, T. / Stenmark, P. Funding support Sweden, Germany, 12items Details Hide detailsOrganization Grant number Country Swedish Society for Medical research Sweden Karolinska Institute KID funding Sweden German Research Foundation Germany Knut and Alice Wallenberg Foundation Sweden Swedish Foundation for Strategic Research Sweden Swedish Cancer Society Sweden Swedish Research Council Sweden Wenner-Gren Foundation Sweden Goran Gustafsson Foundation Sweden Swedish Children's Cancer Foundation Sweden Swedish Pain Relief Foundation Sweden Torsten and Ragnar Soderberg Foundation Sweden
CitationJournal : Cancer Res. / Year : 2016Title : Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition.Authors : Brautigam, L. / Pudelko, L. / Jemth, A.S. / Gad, H. / Narwal, M. / Gustafsson, R. / Karsten, S. / Carreras Puigvert, J. / Homan, E. / Berndt, C. / Berglund, U.W. / Stenmark, P. / Helleday, T. History Deposition Feb 3, 2016 Deposition site : RCSB / Processing site : PDBERevision 1.0 Feb 10, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Feb 24, 2016 Group : Structure summaryRevision 1.2 Jun 1, 2016 Group : Database referencesRevision 1.3 Sep 6, 2017 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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