Entry Database : PDB / ID : 5hzx Structure visualization Downloads & linksTitle Crystal structure of zebrafish MTH1 in complex with TH588 ComponentsNudix (Nucleoside diphosphate linked moiety X)-type motif 1 Details Keywords HYDROLASE / Inhibitor / Complex / MTH1 / TH588Function / homology Function and homology informationFunction Domain/homology Component
purine deoxyribonucleotide metabolic process / Phosphate bond hydrolysis by NUDT proteins / nucleoside triphosphate diphosphatase activity / 2-hydroxy-dATP diphosphatase / hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides / 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity / DNA protection / phosphatase activity / Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides / mitochondrial matrix ... purine deoxyribonucleotide metabolic process / Phosphate bond hydrolysis by NUDT proteins / nucleoside triphosphate diphosphatase activity / 2-hydroxy-dATP diphosphatase / hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides / 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity / DNA protection / phosphatase activity / Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides / mitochondrial matrix / RNA binding / nucleus / metal ion binding / cytosol / cytoplasm Similarity search - Function Oxidized purine nucleoside triphosphate / NUDIX hydrolase / NUDIX hydrolase, conserved site / Nudix box signature. / Nucleoside Triphosphate Pyrophosphohydrolase / Nucleoside Triphosphate Pyrophosphohydrolase / NUDIX domain / Nudix hydrolase domain profile. / NUDIX hydrolase domain / NUDIX hydrolase-like domain superfamily ... Oxidized purine nucleoside triphosphate / NUDIX hydrolase / NUDIX hydrolase, conserved site / Nudix box signature. / Nucleoside Triphosphate Pyrophosphohydrolase / Nucleoside Triphosphate Pyrophosphohydrolase / NUDIX domain / Nudix hydrolase domain profile. / NUDIX hydrolase domain / NUDIX hydrolase-like domain superfamily / Alpha-Beta Complex / Alpha Beta Similarity search - Domain/homologyBiological species Danio rerio (zebrafish)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.9 Å DetailsAuthors Narwal, M. / Gustafsson, R. / Brautigam, L. / Pudelko, L. / Jemth, A.-S. / Gad, H. / Karsten, S. / Carreras-Puigvert, J. / Homan, E. / Berndt, C. ...Narwal, M. / Gustafsson, R. / Brautigam, L. / Pudelko, L. / Jemth, A.-S. / Gad, H. / Karsten, S. / Carreras-Puigvert, J. / Homan, E. / Berndt, C. / Berglund, U.W. / Helleday, T. / Stenmark, P. Funding support Sweden, Germany, 12items Details Hide detailsOrganization Grant number Country Swedish Society for Medical research Sweden Karolinska Institute KID funding Sweden German Research Foundation Germany Knut and Alice Wallenberg Foundation Sweden Swedish Foundation for Strategic Research Sweden Swedish Cancer Society Sweden Swedish Research Council Sweden Wenner-Gren Foundation Sweden Goran Gustafsson Foundation Sweden Swedish Children's Cancer Foundation Sweden Swedish Pain Relief Foundation Sweden Torsten and Ragnar Soderberg Foundation Sweden
CitationJournal : Cancer Res. / Year : 2016Title : Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition.Authors : Brautigam, L. / Pudelko, L. / Jemth, A.S. / Gad, H. / Narwal, M. / Gustafsson, R. / Karsten, S. / Carreras Puigvert, J. / Homan, E. / Berndt, C. / Berglund, U.W. / Stenmark, P. / Helleday, T. History Deposition Feb 3, 2016 Deposition site : RCSB / Processing site : PDBERevision 1.0 Feb 10, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Feb 24, 2016 Group : Structure summaryRevision 1.2 Jun 1, 2016 Group : Database referencesRevision 1.3 Sep 6, 2017 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
Show all Show less