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TitleHypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition.
Journal, issue, pagesCancer Res., Vol. 76, Page 2366-2375, Year 2016
Publish dateFeb 3, 2016 (structure data deposition date)
AuthorsBrautigam, L. / Pudelko, L. / Jemth, A.S. / Gad, H. / Narwal, M. / Gustafsson, R. / Karsten, S. / Carreras Puigvert, J. / Homan, E. / Berndt, C. ...Brautigam, L. / Pudelko, L. / Jemth, A.S. / Gad, H. / Narwal, M. / Gustafsson, R. / Karsten, S. / Carreras Puigvert, J. / Homan, E. / Berndt, C. / Berglund, U.W. / Stenmark, P. / Helleday, T.
External linksCancer Res. / PubMed:26862114
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-5hzx:
Crystal structure of zebrafish MTH1 in complex with TH588
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-2GE:
N~4~-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • danio rerio (zebrafish)
KeywordsHYDROLASE / Inhibitor / Complex / MTH1 / TH588

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