5HZX

Crystal structure of zebrafish MTH1 in complex with TH588

Summary for 5HZX

• Entry DOI: 10.2210/pdb5hzx/pdb
• Related: 4N1U
• Descriptor: Nudix (Nucleoside diphosphate linked moiety X)-type motif 1, N~4~-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine, SULFATE ION, ... (7 entities in total)
• Functional Keywords: inhibitor, complex, mth1, th588, hydrolase
• Biological source: Danio rerio (Zebrafish)
• Total number of polymer chains: 2
• Total formula weight: 41760.10

Authors

Narwal, M.,Gustafsson, R.,Brautigam, L.,Pudelko, L.,Jemth, A.-S.,Gad, H.,Karsten, S.,Carreras-Puigvert, J.,Homan, E.,Berndt, C.,Berglund, U.W.,Helleday, T.,Stenmark, P. (deposition date: 2016-02-03, release date: 2016-02-10, Last modification date: 2024-01-10)

• Primary citation: Brautigam, L.,Pudelko, L.,Jemth, A.S.,Gad, H.,Narwal, M.,Gustafsson, R.,Karsten, S.,Carreras Puigvert, J.,Homan, E.,Berndt, C.,Berglund, U.W.,Stenmark, P.,Helleday, T.; Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition.; Cancer Res., 76:2366-2375, 2016; PubMed: 26862114; DOI: 10.1158/0008-5472.CAN-15-2380

Experimental method

X-RAY DIFFRACTION (1.9 Å)