登録情報 データベース : PDB / ID : 5e6w 構造の表示 ダウンロードとリンクタイトル Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit 要素Integrin beta-2 詳細 キーワード CELL ADHESION / CD18 fragment機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
integrin alphaX-beta2 complex / positive regulation of prostaglandin-E synthase activity / positive regulation of neutrophil degranulation / integrin alphaM-beta2 complex / integrin alphaL-beta2 complex / ICAM-3 receptor activity / complement component C3b binding / neutrophil migration / Toll Like Receptor 4 (TLR4) Cascade / negative regulation of dopamine metabolic process ... integrin alphaX-beta2 complex / positive regulation of prostaglandin-E synthase activity / positive regulation of neutrophil degranulation / integrin alphaM-beta2 complex / integrin alphaL-beta2 complex / ICAM-3 receptor activity / complement component C3b binding / neutrophil migration / Toll Like Receptor 4 (TLR4) Cascade / negative regulation of dopamine metabolic process / cell-cell adhesion via plasma-membrane adhesion molecules / heterotypic cell-cell adhesion / integrin complex / positive regulation of leukocyte adhesion to vascular endothelial cell / receptor clustering / leukocyte cell-cell adhesion / phagocytosis, engulfment / endodermal cell differentiation / plasma membrane raft / tertiary granule membrane / amyloid-beta clearance / ficolin-1-rich granule membrane / cellular response to low-density lipoprotein particle stimulus / positive regulation of protein targeting to membrane / Integrin cell surface interactions / specific granule membrane / cell adhesion molecule binding / regulation of peptidyl-tyrosine phosphorylation / heat shock protein binding / neutrophil chemotaxis / cell-matrix adhesion / receptor-mediated endocytosis / positive regulation of superoxide anion generation / integrin-mediated signaling pathway / Cell surface interactions at the vascular wall / microglial cell activation / receptor internalization / cell-cell adhesion / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / extracellular vesicle / integrin binding / cell-cell signaling / regulation of cell shape / amyloid-beta binding / Interleukin-4 and Interleukin-13 signaling / receptor complex / cell adhesion / inflammatory response / external side of plasma membrane / focal adhesion / Neutrophil degranulation / apoptotic process / protein kinase binding / cell surface / extracellular exosome / membrane / metal ion binding / plasma membrane 類似検索 - 分子機能 Integrin beta-2 subunit / Integrin beta subunit, cytoplasmic domain / Integrin beta cytoplasmic domain / Integrin_b_cyt / Integrin beta tail domain / Integrin beta subunit, tail / Integrin beta tail domain superfamily / Integrin_B_tail / Integrin beta subunit, VWA domain / Integrin beta subunit ... Integrin beta-2 subunit / Integrin beta subunit, cytoplasmic domain / Integrin beta cytoplasmic domain / Integrin_b_cyt / Integrin beta tail domain / Integrin beta subunit, tail / Integrin beta tail domain superfamily / Integrin_B_tail / Integrin beta subunit, VWA domain / Integrin beta subunit / Integrin beta N-terminal / Integrin beta chain VWA domain / Integrin plexin domain / Integrins beta chain cysteine-rich domain signature. / Integrin beta subunits (N-terminal portion of extracellular region) / Integrin domain superfamily / PSI domain / domain found in Plexins, Semaphorins and Integrins / von Willebrand factor A-like domain superfamily / EGF-like domain signature 2. / EGF-like domain signature 1. 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.2 Å 詳細データ登録者 Springer, T.A. / Sen, M. 資金援助 米国, 1件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Cancer Institute (NIH/NCI) NCI CA031798 米国
引用ジャーナル : J. Biol. Chem. / 年 : 2007タイトル : A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins.著者 : Shi, M. / Foo, S.Y. / Tan, S.M. / Mitchell, E.P. / Law, S.K. / Lescar, J. 履歴 登録 2015年10月10日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2016年3月2日 Provider : repository / タイプ : Initial release改定 1.1 2016年3月16日 Group : Database references改定 1.2 2016年5月11日 Group : Database references改定 1.3 2017年3月15日 Group : Database references / Experimental preparation / Other改定 1.4 2017年9月27日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.5 2019年12月4日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.6 2020年7月29日 Group : Data collection / Derived calculations / Structure summaryカテゴリ : chem_comp / diffrn_radiation_wavelength ... chem_comp / diffrn_radiation_wavelength / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _diffrn_radiation_wavelength.wavelength / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 1.7 2023年9月27日 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
すべて表示 表示を減らす Remark 0 This entry 5E6W reflects an alternative modeling of the structural data in r2P28SF original data ... This entry 5E6W reflects an alternative modeling of the structural data in r2P28SF original data determined by Authors: Shi, M., Foo, S.Y., Tan, S.M., Mitchell, E.P., Law, S.K.A., Lescar, J.