登録情報 | データベース: PDB / ID: 4jlg |
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タイトル | SETD7 in complex with inhibitor (R)-PFI-2 and S-adenosyl-methionine |
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要素 | Histone-lysine N-methyltransferase SETD7 |
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / Methyltransferase / SET domain / histone modification / transcription regulation / histone lysine methyltransferase / inhibitor / S-adenosyl-L-methionine / Structural Genomics / Structural Genomics Consortium / SGC / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
heterochromatin organization / peptidyl-lysine monomethylation / peptidyl-lysine dimethylation / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / protein-lysine N-methyltransferase activity / histone H3 methyltransferase activity / histone methyltransferase activity / PKMTs methylate histone lysines / p53 binding ...heterochromatin organization / peptidyl-lysine monomethylation / peptidyl-lysine dimethylation / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / protein-lysine N-methyltransferase activity / histone H3 methyltransferase activity / histone methyltransferase activity / PKMTs methylate histone lysines / p53 binding / chromatin organization / chromosome / response to ethanol / DNA damage response / chromatin binding / nucleolus / positive regulation of DNA-templated transcription / nucleoplasm / nucleus類似検索 - 分子機能 Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain / Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain / Histone-lysine N-methyltransferase, SET / SETD7, SET domain / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / MORN motif / MORN repeat / Beta-clip-like / SET domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain ...Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain / Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain / Histone-lysine N-methyltransferase, SET / SETD7, SET domain / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / MORN motif / MORN repeat / Beta-clip-like / SET domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / Single Sheet / Beta Complex / Mainly Beta類似検索 - ドメイン・相同性 Chem-1L8 / S-ADENOSYLMETHIONINE / Histone-lysine N-methyltransferase SETD7類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.896 Å |
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データ登録者 | Dong, A. / Wu, H. / Zeng, H. / El Bakkouri, M. / Barsyte, D. / Vedadi, M. / Tatlock, J. / Owen, D. / Bunnage, M. / Bountra, C. ...Dong, A. / Wu, H. / Zeng, H. / El Bakkouri, M. / Barsyte, D. / Vedadi, M. / Tatlock, J. / Owen, D. / Bunnage, M. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. / Brown, P.J. / Structural Genomics Consortium (SGC) |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2014 タイトル: (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. 著者: Barsyte-Lovejoy, D. / Li, F. / Oudhoff, M.J. / Tatlock, J.H. / Dong, A. / Zeng, H. / Wu, H. / Freeman, S.A. / Schapira, M. / Senisterra, G.A. / Kuznetsova, E. / Marcellus, R. / Allali- ...著者: Barsyte-Lovejoy, D. / Li, F. / Oudhoff, M.J. / Tatlock, J.H. / Dong, A. / Zeng, H. / Wu, H. / Freeman, S.A. / Schapira, M. / Senisterra, G.A. / Kuznetsova, E. / Marcellus, R. / Allali-Hassani, A. / Kennedy, S. / Lambert, J.P. / Couzens, A.L. / Aman, A. / Gingras, A.C. / Al-Awar, R. / Fish, P.V. / Gerstenberger, B.S. / Roberts, L. / Benn, C.L. / Grimley, R.L. / Braam, M.J. / Rossi, F.M. / Sudol, M. / Brown, P.J. / Bunnage, M.E. / Owen, D.R. / Zaph, C. / Vedadi, M. / Arrowsmith, C.H. |
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履歴 | 登録 | 2013年3月12日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年4月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2014年4月9日 | Group: Structure summary |
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改定 1.2 | 2015年2月18日 | Group: Database references |
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改定 1.3 | 2023年9月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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