登録情報 | データベース: PDB / ID: 5ylt |
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タイトル | Crystal structure of SET7/9 in complex with a cyproheptadine derivative |
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要素 | Histone-lysine N-methyltransferase SETD7 |
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / Set domain / methyltransferase / inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
heterochromatin organization / peptidyl-lysine monomethylation / peptidyl-lysine dimethylation / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / protein-lysine N-methyltransferase activity / histone H3 methyltransferase activity / histone methyltransferase activity / regulation of DNA repair / PKMTs methylate histone lysines ...heterochromatin organization / peptidyl-lysine monomethylation / peptidyl-lysine dimethylation / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / protein-lysine N-methyltransferase activity / histone H3 methyltransferase activity / histone methyltransferase activity / regulation of DNA repair / PKMTs methylate histone lysines / p53 binding / chromosome / chromatin organization / response to ethanol / DNA damage response / chromatin binding / positive regulation of DNA-templated transcription / nucleolus / nucleoplasm / nucleus類似検索 - 分子機能 Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain / Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain / Histone-lysine N-methyltransferase, SET / SETD7, SET domain / : / Histone H3 K4-specific methyltransferase SET7 N-terminal / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / MORN motif / MORN repeat / Beta-clip-like ...Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain / Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain / Histone-lysine N-methyltransferase, SET / SETD7, SET domain / : / Histone H3 K4-specific methyltransferase SET7 N-terminal / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / MORN motif / MORN repeat / Beta-clip-like / SET domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain / SET domain superfamily / SET domain profile. / SET domain / Single Sheet / Beta Complex / Mainly Beta類似検索 - ドメイン・相同性 Chem-C7N / SINEFUNGIN / Histone-lysine N-methyltransferase SETD7類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.69 Å |
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データ登録者 | Hirano, T. / Fujiwara, T. / Niwa, H. / Hirano, M. / Ohira, K. / Okazaki, Y. / Sato, S. / Umehara, T. / Maemoto, Y. / Ito, A. ...Hirano, T. / Fujiwara, T. / Niwa, H. / Hirano, M. / Ohira, K. / Okazaki, Y. / Sato, S. / Umehara, T. / Maemoto, Y. / Ito, A. / Yoshida, M. / Kagechika, H. |
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資金援助 | 日本, 4件 組織 | 認可番号 | 国 |
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The Ministry of Education, Science, Sports and Culture, Japan | 15K08019 | 日本 | The Ministry of Education, Science, Sports and Culture, Japan | 26670052 | 日本 | The Ministry of Education, Science, Sports and Culture, Japan | 24613007 | 日本 | The Ministry of Education, Science, Sports and Culture, Japan | 26221204 | 日本 |
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引用 | ジャーナル: ChemMedChem / 年: 2018 タイトル: Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine. 著者: Hirano, T. / Fujiwara, T. / Niwa, H. / Hirano, M. / Ohira, K. / Okazaki, Y. / Sato, S. / Umehara, T. / Maemoto, Y. / Ito, A. / Yoshida, M. / Kagechika, H. |
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履歴 | 登録 | 2017年10月19日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2018年6月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年9月5日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID |
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改定 1.2 | 2023年11月22日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.3 | 2024年10月16日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature |
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