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| Title | (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. |
|---|---|
| Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 111, Page 12853-12858, Year 2014 |
| Publish date | Mar 12, 2013 (structure data deposition date) |
 Authors | Barsyte-Lovejoy, D. / Li, F. / Oudhoff, M.J. / Tatlock, J.H. / Dong, A. / Zeng, H. / Wu, H. / Freeman, S.A. / Schapira, M. / Senisterra, G.A. ...Barsyte-Lovejoy, D. / Li, F. / Oudhoff, M.J. / Tatlock, J.H. / Dong, A. / Zeng, H. / Wu, H. / Freeman, S.A. / Schapira, M. / Senisterra, G.A. / Kuznetsova, E. / Marcellus, R. / Allali-Hassani, A. / Kennedy, S. / Lambert, J.P. / Couzens, A.L. / Aman, A. / Gingras, A.C. / Al-Awar, R. / Fish, P.V. / Gerstenberger, B.S. / Roberts, L. / Benn, C.L. / Grimley, R.L. / Braam, M.J. / Rossi, F.M. / Sudol, M. / Brown, P.J. / Bunnage, M.E. / Owen, D.R. / Zaph, C. / Vedadi, M. / Arrowsmith, C.H. |
 External links | Proc. Natl. Acad. Sci. USA / PubMed:25136132 |
| Methods | X-ray diffraction |
| Resolution | 1.896 Å |
| Structure data |  PDB-4jlg: |
| Chemicals |  ChemComp-SAM:  ChemComp-1L8:  ChemComp-UNX:  ChemComp-HOH: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Methyltransferase / SET domain / histone modification / transcription regulation / histone lysine methyltransferase / inhibitor / S-adenosyl-L-methionine / Structural Genomics / Structural Genomics Consortium / SGC / TRANSFERASE-TRANSFERASE INHIBITOR complex |
homo sapiens (human)