- PDB-4ajs: 3D structure of E. coli Isocitrate Dehydrogenase K100M mutant in ... -
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Basic information
Entry
Database: PDB / ID: 4ajs
Title
3D structure of E. coli Isocitrate Dehydrogenase K100M mutant in complex with isocitrate, magnesium(II), Adenosine 2',5'-biphosphate and ribosylnicotinamide-5'-phosphate
Components
ISOCITRATE DEHYDROGENASE [NADP]
Keywords
OXIDOREDUCTASE / OXIDATIVE BETA-DECARBOXYLATION
Function / homology
Function and homology information
isocitrate dehydrogenase (NADP+) / isocitrate dehydrogenase (NADP+) activity / glyoxylate cycle / guanosine tetraphosphate binding / tricarboxylic acid cycle / electron transport chain / NAD binding / response to oxidative stress / magnesium ion binding / cytosol / cytoplasm Similarity search - Function
Mass: 18.015 Da / Num. of mol.: 504 / Source method: isolated from a natural source / Formula: H2O
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Details
Nonpolymer details
RIBOSYLNICOTINAMIDE-5'-PHOSPHATE (NMN): NADP FRAGMENT FROM HYDROLYSIS ADENOSINE 2',5'-BIPHOSPHATE ...RIBOSYLNICOTINAMIDE-5'-PHOSPHATE (NMN): NADP FRAGMENT FROM HYDROLYSIS ADENOSINE 2',5'-BIPHOSPHATE (A2P): NADP FRAGMENT FROM HYDROLYSIS
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 4.5 Å3/Da / Density % sol: 72 % / Description: NONE
Crystal grow
Details: 1.85 M NH4SO4, 50 MM CITRIC ACID/NA2HPO4 BUFFER PH 5.2, 0.1 M NACL AND 0.2 M DTT.
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