登録情報 | データベース: PDB / ID: 4ai8 |
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タイトル | FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH DAMINOZIDE |
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要素 | HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR |
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キーワード | OXIDOREDUCTASE / DIOXYGENASE / METAL-BINDING / HELIX-LOOP-HELIX-BETA / DSBH / FACIAL TRIAD / TRANSCRIPTION AND EPIGENETIC REGULATION / ANKYRIN REPEAT DOMAIN / BETA-HYDROXYLATION / TRANSCRIPTION ACTIVATOR/INHIBITOR |
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機能・相同性 | 機能・相同性情報
hypoxia-inducible factor-asparagine dioxygenase / : / [protein]-asparagine 3-dioxygenase activity / peptidyl-histidine dioxygenase activity / peptidyl-aspartic acid 3-dioxygenase activity / Cellular response to hypoxia / carboxylic acid binding / positive regulation of vasculogenesis / ankyrin repeat binding / oxygen sensor activity ...hypoxia-inducible factor-asparagine dioxygenase / : / [protein]-asparagine 3-dioxygenase activity / peptidyl-histidine dioxygenase activity / peptidyl-aspartic acid 3-dioxygenase activity / Cellular response to hypoxia / carboxylic acid binding / positive regulation of vasculogenesis / ankyrin repeat binding / oxygen sensor activity / Notch binding / negative regulation of Notch signaling pathway / NF-kappaB binding / positive regulation of myoblast differentiation / ferrous iron binding / transcription corepressor activity / perinuclear region of cytoplasm / protein homodimerization activity / zinc ion binding / nucleoplasm / cytoplasm / cytosol類似検索 - 分子機能 Clavaminate synthase-like / Hypoxia-inducible factor 1-alpha inhibitor, domain II / Cupin-like domain 8 / Cupin-like domain / A domain family that is part of the cupin metalloenzyme superfamily. / Jelly Rolls / JmjC domain / JmjC domain profile. / RmlC-like jelly roll fold / Helix Hairpins ...Clavaminate synthase-like / Hypoxia-inducible factor 1-alpha inhibitor, domain II / Cupin-like domain 8 / Cupin-like domain / A domain family that is part of the cupin metalloenzyme superfamily. / Jelly Rolls / JmjC domain / JmjC domain profile. / RmlC-like jelly roll fold / Helix Hairpins / Jelly Rolls / Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性 DAMINOZIDE / Hypoxia-inducible factor 1-alpha inhibitor類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.4 Å |
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データ登録者 | King, O.N.F. / Chowdhury, R. / Rose, N.R. / McDonough, M.A. / Clifton, I.J. / Schofield, C.J. / Kawamura, A. |
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引用 | ジャーナル: J. Med. Chem. / 年: 2012 タイトル: Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. 著者: Rose, N.R. / Woon, E.C. / Tumber, A. / Walport, L.J. / Chowdhury, R. / Li, X.S. / King, O.N. / Lejeune, C. / Ng, S.S. / Krojer, T. / Chan, M.C. / Rydzik, A.M. / Hopkinson, R.J. / Che, K.H. / ...著者: Rose, N.R. / Woon, E.C. / Tumber, A. / Walport, L.J. / Chowdhury, R. / Li, X.S. / King, O.N. / Lejeune, C. / Ng, S.S. / Krojer, T. / Chan, M.C. / Rydzik, A.M. / Hopkinson, R.J. / Che, K.H. / Daniel, M. / Strain-Damerell, C. / Gileadi, C. / Kochan, G. / Leung, I.K. / Dunford, J. / Yeoh, K.K. / Ratcliffe, P.J. / Burgess-Brown, N. / von Delft, F. / Muller, S. / Marsden, B. / Brennan, P.E. / McDonough, M.A. / Oppermann, U. / Klose, R.J. / Schofield, C.J. / Kawamura, A. |
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履歴 | 登録 | 2012年2月8日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2012年10月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年1月24日 | Group: Database references / カテゴリ: citation_author / Item: _citation_author.name |
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改定 1.2 | 2018年3月7日 | Group: Database references / Source and taxonomy / Structure summary カテゴリ: audit_author / citation ...audit_author / citation / citation_author / entity_src_gen Item: _audit_author.name / _citation.journal_abbrev ..._audit_author.name / _citation.journal_abbrev / _citation.journal_id_ISSN / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation_author.name / _entity_src_gen.gene_src_common_name / _entity_src_gen.pdbx_gene_src_scientific_name / _entity_src_gen.pdbx_host_org_scientific_name / _entity_src_gen.pdbx_host_org_strain |
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改定 1.3 | 2019年1月30日 | Group: Data collection / Experimental preparation / カテゴリ: exptl_crystal_grow / Item: _exptl_crystal_grow.method |
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改定 1.4 | 2019年2月6日 | Group: Data collection / Experimental preparation / カテゴリ: exptl_crystal_grow / Item: _exptl_crystal_grow.temp |
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改定 1.5 | 2023年12月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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