登録情報 | データベース: PDB / ID: 3u7w |
---|
タイトル | Crystal structure of NIH45-46 Fab |
---|
要素 | - Heavy chain, Ig gamma-1 chain C region
- Light chain, Ig kappa chain C region
|
---|
キーワード | IMMUNE SYSTEM / Ig fold / Antibody / HIV gp120 |
---|
機能・相同性 | 機能・相同性情報
IgD immunoglobulin complex / IgM immunoglobulin complex / IgA immunoglobulin complex / IgE immunoglobulin complex / Fc-gamma receptor I complex binding / CD22 mediated BCR regulation / complement-dependent cytotoxicity / IgG immunoglobulin complex / Fc epsilon receptor (FCERI) signaling / antibody-dependent cellular cytotoxicity ...IgD immunoglobulin complex / IgM immunoglobulin complex / IgA immunoglobulin complex / IgE immunoglobulin complex / Fc-gamma receptor I complex binding / CD22 mediated BCR regulation / complement-dependent cytotoxicity / IgG immunoglobulin complex / Fc epsilon receptor (FCERI) signaling / antibody-dependent cellular cytotoxicity / Classical antibody-mediated complement activation / Initial triggering of complement / FCGR activation / immunoglobulin mediated immune response / Role of phospholipids in phagocytosis / Role of LAT2/NTAL/LAB on calcium mobilization / Scavenging of heme from plasma / immunoglobulin complex, circulating / immunoglobulin receptor binding / FCERI mediated Ca+2 mobilization / FCGR3A-mediated IL10 synthesis / complement activation, classical pathway / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / Regulation of Complement cascade / antigen binding / Cell surface interactions at the vascular wall / FCERI mediated MAPK activation / FCGR3A-mediated phagocytosis / B cell receptor signaling pathway / Regulation of actin dynamics for phagocytic cup formation / FCERI mediated NF-kB activation / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / antibacterial humoral response / Interleukin-4 and Interleukin-13 signaling / adaptive immune response / Potential therapeutics for SARS / blood microparticle / immune response / extracellular space / extracellular exosome / extracellular region / plasma membrane類似検索 - 分子機能 : / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily ...: / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 Immunoglobulin kappa constant / Immunoglobulin heavy constant gamma 1類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.6 Å |
---|
データ登録者 | Diskin, R. / Bjorkman, P.J. |
---|
引用 | ジャーナル: Science / 年: 2011 タイトル: Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design. 著者: Diskin, R. / Scheid, J.F. / Marcovecchio, P.M. / West, A.P. / Klein, F. / Gao, H. / Gnanapragasam, P.N. / Abadir, A. / Seaman, M.S. / Nussenzweig, M.C. / Bjorkman, P.J. |
---|
履歴 | 登録 | 2011年10月14日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2011年11月16日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2011年12月21日 | Group: Database references |
---|
改定 1.2 | 2017年8月2日 | Group: Refinement description / Source and taxonomy / カテゴリ: entity_src_gen / software |
---|
改定 2.0 | 2019年12月25日 | Group: Database references / Derived calculations ...Database references / Derived calculations / Polymer sequence / Refinement description カテゴリ: entity_poly / pdbx_struct_mod_residue ...entity_poly / pdbx_struct_mod_residue / software / struct_conn / struct_ref_seq Item: _entity_poly.pdbx_seq_one_letter_code_can / _pdbx_struct_mod_residue.parent_comp_id ..._entity_poly.pdbx_seq_one_letter_code_can / _pdbx_struct_mod_residue.parent_comp_id / _software.name / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq.db_align_end |
---|
改定 2.1 | 2020年7月29日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
---|
改定 2.2 | 2023年9月13日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|