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Structure paper

TitleIncreasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design.
Journal, issue, pagesScience, Vol. 334, Page 1289-1293, Year 2011
Publish dateOct 14, 2011 (structure data deposition date)
AuthorsDiskin, R. / Scheid, J.F. / Marcovecchio, P.M. / West, A.P. / Klein, F. / Gao, H. / Gnanapragasam, P.N. / Abadir, A. / Seaman, M.S. / Nussenzweig, M.C. / Bjorkman, P.J.
External linksScience / PubMed:22033520
MethodsX-ray diffraction
Resolution2.4478 - 2.6 Å
Structure data

PDB-3u7w:
Crystal structure of NIH45-46 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-3u7y:
Structure of NIH45-46 Fab in complex with gp120 of 93TH057 HIV
Method: X-RAY DIFFRACTION / Resolution: 2.4478 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-FLC:
CITRATE ANION

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
  • human immunodeficiency virus 1
KeywordsIMMUNE SYSTEM / Ig fold / Antibody / HIV gp120 / VIRAL PROTEIN/IMMUNE SYSTEM / gp120 / anti HIV / Glycosylation / VIRAL PROTEIN-IMMUNE SYSTEM complex

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