Author results

3J6Q
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IDENTIFICATION OF THE ACTIVE SITES IN THE METHYLTRANSFERASES OF A TRANSCRIBING DSRNA VIRUS
Descriptor:Structural protein VP3, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Zhu, B., Yang, C., Liu, H., Cheng, L., Song, F., Zeng, S., Huang, X., Ji, G., Zhu, P.
Deposit date:2014-03-20
Release date:2014-10-08
Last modified:2014-10-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Identification of the active sites in the methyltransferases of a transcribing dsRNA virus.
J.Mol.Biol., 426, 2014
5SYB
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CRYSTAL STRUCTURE OF HUMAN PHF5A
Descriptor:PHD finger-like domain-containing protein 5A, ZINC ION, 1,2-ETHANEDIOL
Authors:Tsai, J.H.C., Teng, T., Zhu, P., Fekkes, P., Larsen, N.A.
Deposit date:2016-08-10
Release date:2016-09-07
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Nat Commun, 8, 2017
5X0T
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CRYSTAL STRUCTURE OF CD147 C2 DOMAIN IN COMPLEX WITH FAB OF ITS MONOCLONAL ANTIBODY 6H8
Descriptor:6H8 Fab fragment heavy chain, 6H8 Fab fragment light chain, Basigin
Authors:Lin, P., Zhang, M.-Y., Ye, S., Chen, X., Yu, X.-L., Zhang, R.-G., Zhu, P., Chen, Z.-N.
Deposit date:2017-01-23
Release date:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody
To Be Published
5X4G
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CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI-CD147 MONOCLONAL ANTIBODY 6H8
Descriptor:6H8 Fab heavy chain, 6H8 Fab light chain
Authors:Lin, P., Zhang, M.-Y., Chen, X., Ye, S., Yu, X.-L., Zhang, R.-G., Zhu, P., Chen, Z.-N.
Deposit date:2017-02-13
Release date:2018-01-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody
To Be Published
2IJ0
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STRUCTURAL BASIS OF T CELL SPECIFICITY AND ACTIVATION BY THE BACTERIAL SUPERANTIGEN TOXIC SHOCK SYNDROME TOXIN-1
Descriptor:Toxic shock syndrome toxin-1, penultimate affinity-matured variant of hVbeta 2.1, D10
Authors:Moza, B., Varma, A.K., Buonpane, R.A., Zhu, P., Herfst, C.A., Nicholson, M.J., Wilbuer, A.K., Nulifer, S., Wucherpfenning, K.W., McCormick, J.K., Kranz, D.M., Sundberg, E.J.
Deposit date:2006-09-28
Release date:2007-02-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1.
Embo J., 26, 2007
3IZ3
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CRYOEM STRUCTURE OF CYTOPLASMIC POLYHEDROSIS VIRUS
Descriptor:Structural protein VP3, Structural protein VP1, Viral structural protein 5
Authors:Cheng, L., Sun, J., Zhang, K., Mou, Z., Huang, X., Ji, G., Sun, F., Zhang, J., Zhu, P.
Deposit date:2010-09-14
Release date:2011-03-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping.
Proc.Natl.Acad.Sci.USA, 108, 2011
3J17
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STRUCTURE OF A TRANSCRIBING CYPOVIRUS BY CRYO-ELECTRON MICROSCOPY
Descriptor:Structural protein VP3, VP1, Structural protein VP5
Authors:Yang, C., Ji, G., Liu, H., Zhang, K., Liu, G., Sun, F., Zhu, P., Cheng, L.
Deposit date:2011-12-25
Release date:2012-04-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of a transcribing cypovirus.
Proc.Natl.Acad.Sci.USA, 109, 2012
3ZIF
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CRYO-EM STRUCTURES OF TWO INTERMEDIATES PROVIDE INSIGHT INTO ADENOVIRUS ASSEMBLY AND DISASSEMBLY
Descriptor:HEXON PROTEIN, PENTON PROTEIN, PIX, ...
Authors:Cheng, L., Huang, X., Li, X., Xiong, W., Sun, W., Yang, C., Zhang, K., Wang, Y., Liu, H., Ji, G., Sun, F., Zheng, C., Zhu, P.
Deposit date:2013-01-09
Release date:2014-01-22
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-Em Structures of Two Bovine Adenovirus Type 3 Intermediates
Virology, 450, 2014
4J1G
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LEANYER ORTHOBUNYAVIRUS NUCLEOPROTEIN-SSRNA COMPLEX
Descriptor:Nucleocapsid, RNA (45-MER)
Authors:Niu, F., Shaw, N., Wang, Y., Jiao, L., Ding, W., Li, X., Zhu, P., Upur, H., Ouyang, S., Cheng, G., Liu, Z.J.
Deposit date:2013-02-01
Release date:2013-04-10
Last modified:2013-06-12
Method:X-RAY DIFFRACTION (2.789 Å)
Cite:Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4J1J
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LEANYER ORTHOBUNYAVIRUS NUCLEOPROTEIN-SSDNA COMPLEX
Descriptor:Nucleocapsid, DNA (5'-D(P*AP*CP*CP*AP*AP*AP*CP*AP*AP*CP*CP*CP*AP*CP*CP*CP*A)-3')
Authors:Niu, F., Shaw, N., Wang, Y., Jiao, L., Ding, W., Li, X., Zhu, P., Upur, H., Ouyang, S., Cheng, G., Liu, Z.J.
Deposit date:2013-02-01
Release date:2013-04-10
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation.
Proc.Natl.Acad.Sci.USA, 110, 2013
6O8A
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THAUMATIN NATIVE-SAD STRUCTURE DETERMINED AT 5 KEV FROM MICROCRYSTALS
Descriptor:Thaumatin-1, L(+)-TARTARIC ACID
Authors:Guo, G., Zhu, P., Fuchs, M.R., Shi, W., Andi, B., Gao, Y., Hendrickson, W.A., McSweeney, S., Liu, Q.
Deposit date:2019-03-09
Release date:2019-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Synchrotron microcrystal native-SAD phasing at a low energy
Iucrj, 2019
5ZBF
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CRYSTAL STRUCTURE OF 4-HYDROXYPHENYLPYRUVIC ACID BOUND AERE FROM MICROCYSTIS AERUGINOSA
Descriptor:Cupin domain protein, 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, FE (II) ION
Authors:Qiu, X., Zhu, W.
Deposit date:2018-02-11
Release date:2019-02-13
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and functional insights into the role of a cupin superfamily isomerase in the biosynthesis of Choi moiety of aeruginosin.
J. Struct. Biol., 205, 2019
2MKZ
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SOLUTION STRUCTURE OF A PROTEIN C-TERMINAL DOMAIN
Descriptor:Proteasomal ubiquitin receptor ADRM1
Authors:Feng, Y., Jiao, L.
Deposit date:2014-02-17
Release date:2014-12-31
Method:SOLUTION NMR
Cite:Mechanism of the Rpn13-induced activation of Uch37
Protein Cell, 5, 2014
5ZBE
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CRYSTAL STRUCTURE OF AERE FROM MICROCYSTIS AERUGINOSA
Descriptor:Cupin domain protein, FE (II) ION, TRIETHYLENE GLYCOL
Authors:Qiu, X.
Deposit date:2018-02-11
Release date:2019-02-13
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and functional insights into the role of a cupin superfamily isomerase in the biosynthesis of Choi moiety of aeruginosin.
J. Struct. Biol., 205, 2019
5ZWX
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CRYSTAL STRUCTURE OF RAPHANUS SATIVUS AGDP1 AGD12 IN COMPLEX WITH AN H3K9ME2 PEPTIDE
Descriptor:DUF724 domain-containing protein 6-like, H3(1-15)K9me2 peptide
Authors:Du, X., Du, J.
Deposit date:2018-05-17
Release date:2018-11-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin
Nat Commun, 9, 2018
5ZWZ
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA AGDP1 AGD34
Descriptor:Agenet domain-containing protein
Authors:Du, X., Du, J.
Deposit date:2018-05-17
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin
Nat Commun, 9, 2018
5VND
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CRYSTAL STRUCTURE OF FGFR1-Y563C (FGFR4 SURROGATE) COVALENTLY BOUND TO H3B-6527
Descriptor:Fibroblast growth factor receptor 1, N-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide, SULFATE ION, ...
Authors:Tsai, J.H.C., Reynolds, D., Fekkes, P., Smith, P., Larsen, N.A.
Deposit date:2017-04-30
Release date:2017-05-24
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma.
Cancer Res., 77, 2017
5EHR
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NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASE SHP2 IN COMPLEX WITH ALLOSTERIC INHIBITOR SHP099
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, PHOSPHATE ION
Authors:Stams, T., Fodor, M.
Deposit date:2015-10-28
Release date:2016-06-29
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Nature, 535, 2016
5J9Q
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CRYSTAL STRUCTURE OF THE NUA4 CORE COMPLEX
Descriptor:Histone acetyltransferase ESA1, Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, ...
Authors:Chen, Z.C., Xu, P.
Deposit date:2016-04-11
Release date:2016-10-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism
Mol.Cell, 63, 2016
5J9T
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CRYSTAL STRUCTURE OF THE NUA4 CORE COMPLEX
Descriptor:Histone acetyltransferase ESA1, Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, ...
Authors:Chen, Z.C., Xu, P.
Deposit date:2016-04-11
Release date:2016-10-26
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism
Mol.Cell, 63, 2016
5J9U
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CRYSTAL STRUCTURE OF THE NUA4 CORE COMPLEX
Descriptor:Histone acetyltransferase ESA1, Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, ...
Authors:Chen, Z.C., Xu, P.
Deposit date:2016-04-11
Release date:2016-10-26
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism
Mol.Cell, 63, 2016
5J9W
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CRYSTAL STRUCTURE OF THE NUA4 CORE COMPLEX
Descriptor:Histone acetyltransferase ESA1, Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, ...
Authors:Chen, Z.C., Xu, P.
Deposit date:2016-04-11
Release date:2016-10-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism
Mol.Cell, 63, 2016
6CHW
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ESTROGEN RECEPTOR ALPHA Y537S COVALENTLY BOUND TO ANTAGONIST H3B-5942.
Descriptor:Estrogen receptor, 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide, 1,2-ETHANEDIOL, ...
Authors:Larsen, N.A.
Deposit date:2018-02-23
Release date:2018-03-21
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer.
Cancer Discov, 8, 2018
6CHZ
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ESTROGEN RECEPTOR ALPHA Y537S BOUND TO ANTAGONIST H3B-9224.
Descriptor:Estrogen receptor, 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide, 1,2-ETHANEDIOL
Authors:Larsen, N.A.
Deposit date:2018-02-23
Release date:2018-03-21
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer.
Cancer Discov, 8, 2018
4GA7
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CRYSTAL STRUCTURE OF HUMAN SERPINB1 MUTANT
Descriptor:Leukocyte elastase inhibitor
Authors:Wang, L., Li, Q., Wu, L., Zhang, K., Tong, L., Sun, F., Fan, Z.
Deposit date:2012-07-25
Release date:2013-01-16
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of SERPINB1 as a physiological inhibitor of human granzyme H
J.Immunol., 190, 2013
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