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3CEQ
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BU of 3ceq by Molmil
The TPR domain of Human Kinesin Light Chain 2 (hKLC2)
Descriptor: Kinesin light chain 2
Authors:Zhu, H, Shen, Y, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2008-02-29
Release date:2008-08-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The TPR domain of Human Kinesin Light Chain 2 (hKLC2)
To be Published
3EDT
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BU of 3edt by Molmil
Crystal structure of the mutated S328N hKLC2 TPR domain
Descriptor: Kinesin light chain 2, UNKNOWN ATOM OR ION
Authors:Zhu, H, Shen, Y, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2008-09-03
Release date:2009-02-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of mutated S328N TPR domain of human kinesin light chain 2
To be published
3B6V
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BU of 3b6v by Molmil
Crystal structure of the motor domain of human kinesin family member 3C in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF3C, MAGNESIUM ION, ...
Authors:Zhu, H, Tempel, W, Shen, Y, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2007-10-29
Release date:2007-11-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Motor domain of human kinesin family member 3C in complex with ADP.
To be Published
3B6U
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BU of 3b6u by Molmil
Crystal structure of the motor domain of human kinesin family member 3B in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF3B, MAGNESIUM ION, ...
Authors:Zhu, H, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2007-10-29
Release date:2007-11-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Motor domain of human kinesin family member 3B in complex with ADP.
To be Published
8FO8
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BU of 8fo8 by Molmil
Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 dimer state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, ...
Authors:Zhu, H, Sun, J.
Deposit date:2022-12-29
Release date:2024-01-03
Method:ELECTRON MICROSCOPY (3.88 Å)
Cite:Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2.
Science, 382, 2023
3NWN
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BU of 3nwn by Molmil
Crystal structure of the human KIF9 motor domain in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Kinesin-like protein KIF9, ...
Authors:Zhu, H, Tempel, W, He, H, Shen, Y, Wang, J, Brothers, G, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2010-07-09
Release date:2010-07-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the human KIF9 motor domain in complex with ADP
To be Published
2FAQ
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BU of 2faq by Molmil
Crystal Structure of Pseudomonas aeruginosa LigD polymerase domain with ATP and Manganese
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, SULFATE ION, ...
Authors:Zhu, H, Nandakumar, J, Aniukwu, J, Wang, L.K, Glickman, M.S, Lima, C.D, Shuman, S.
Deposit date:2005-12-07
Release date:2006-05-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D
Proc.Natl.Acad.Sci.USA, 103, 2006
2FAO
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BU of 2fao by Molmil
Crystal Structure of Pseudomonas aeruginosa LigD polymerase domain
Descriptor: SULFATE ION, probable ATP-dependent DNA ligase
Authors:Zhu, H, Nandakumar, J, Aniukwu, J, Wang, L.K, Glickman, M.S, Lima, C.D, Shuman, S.
Deposit date:2005-12-07
Release date:2006-05-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D
Proc.Natl.Acad.Sci.USA, 103, 2006
2FAR
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BU of 2far by Molmil
Crystal Structure of Pseudomonas aeruginosa LigD polymerase domain with dATP and Manganese
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MANGANESE (II) ION, SULFATE ION, ...
Authors:Zhu, H, Nandakumar, J, Aniukwu, J, Wang, L.K, Glickman, M.S, Lima, C.D, Shuman, S.
Deposit date:2005-12-07
Release date:2006-05-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D
Proc.Natl.Acad.Sci.USA, 103, 2006
8U8B
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BU of 8u8b by Molmil
Cryo-EM structure of LRRK2 bound to type II inhibitor rebastinib
Descriptor: 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2
Authors:Zhu, H, Sun, J.
Deposit date:2023-09-16
Release date:2024-01-31
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM.
Cell Discov, 10, 2024
8U7H
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BU of 8u7h by Molmil
Cryo-EM structure of LRRK2 bound to type I inhibitor GNE-7915
Descriptor: GUANOSINE-5'-DIPHOSPHATE, [4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoranyl-5-methoxy-phenyl]-morpholin-4-yl-methanone, non-specific serine/threonine protein kinase
Authors:Zhu, H, Sun, J.
Deposit date:2023-09-15
Release date:2024-01-31
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM.
Cell Discov, 10, 2024
8U8A
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BU of 8u8a by Molmil
Cryo-EM structure of LRRK2 bound to type II inhibitor ponatinib
Descriptor: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2
Authors:Zhu, H, Sun, J.
Deposit date:2023-09-16
Release date:2024-01-31
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM.
Cell Discov, 10, 2024
8U7L
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BU of 8u7l by Molmil
Cryo-EM structure of LRRK2 bound to type II inhibitor GZD824
Descriptor: 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2
Authors:Zhu, H, Sun, J.
Deposit date:2023-09-15
Release date:2024-01-31
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM.
Cell Discov, 10, 2024
8FO2
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BU of 8fo2 by Molmil
Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 monomer state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, ...
Authors:Zhu, H, Sun, J.
Deposit date:2022-12-29
Release date:2024-01-03
Method:ELECTRON MICROSCOPY (4.13 Å)
Cite:Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2.
Science, 382, 2023
8FO9
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BU of 8fo9 by Molmil
Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 tetramer state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, ...
Authors:Zhu, H, Sun, J.
Deposit date:2022-12-30
Release date:2024-01-03
Method:ELECTRON MICROSCOPY (3.48 Å)
Cite:Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2.
Science, 382, 2023
1R1N
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BU of 1r1n by Molmil
Tri-nuclear oxo-iron clusters in the ferric binding protein from N. gonorrhoeae
Descriptor: Ferric-iron Binding Protein, OXO-IRON CLUSTER 1, OXO-IRON CLUSTER 2, ...
Authors:Zhu, H, Alexeev, D, Hunter, D.J, Campopiano, D.J, Sadler, P.J.
Deposit date:2003-09-24
Release date:2004-03-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif.
Biochem.J., 376, 2003
2P5S
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BU of 2p5s by Molmil
RAB domain of human RASEF in complex with GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, RAS and EF-hand domain containing, UNKNOWN ATOM OR ION
Authors:Zhu, H, Wang, J, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2007-03-16
Release date:2007-03-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:RAB domain of human RASEF in complex with GDP
To be Published
2PMY
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BU of 2pmy by Molmil
EF-hand domain of human RASEF
Descriptor: CALCIUM ION, RAS and EF-hand domain-containing protein, SULFATE ION, ...
Authors:Zhu, H, Shen, Y, Wang, J, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2007-04-23
Release date:2007-05-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:EF-hand domain of human RASEF
To be Published
7MLV
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BU of 7mlv by Molmil
Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric tetramer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3D1 Fab Heavy Chain, 3D1 Fab Light Chain, ...
Authors:Zhu, H, Gouaux, E.
Deposit date:2021-04-29
Release date:2021-09-29
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Architecture and assembly mechanism of native glycine receptors.
Nature, 599, 2021
7MLU
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BU of 7mlu by Molmil
Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric pentamer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3D1 Fab Heavy Chain, 3D1 Fab Light Chain, ...
Authors:Zhu, H, Gouaux, E.
Deposit date:2021-04-29
Release date:2021-09-29
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Architecture and assembly mechanism of native glycine receptors.
Nature, 599, 2021
7MLY
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BU of 7mly by Molmil
Cryo-EM reveals partially and fully assembled native glycine receptors,heteromeric pentamer
Descriptor: 3D1 Fab Heavy Chain, 3D1 Fab Light Chain, DECANE, ...
Authors:Zhu, H, Gouaux, E.
Deposit date:2021-04-29
Release date:2021-09-29
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Architecture and assembly mechanism of native glycine receptors.
Nature, 599, 2021
8FO7
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BU of 8fo7 by Molmil
Cryo-EM structure of LRRK2 bound to type I inhibitor LRRK2-IN-1
Descriptor: 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2
Authors:Zhu, H, Sun, J.
Deposit date:2022-12-29
Release date:2024-01-17
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM.
Cell Discov, 10, 2024
7U2N
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BU of 7u2n by Molmil
A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-open state
Descriptor: Glycine receptor subunit alphaZ1, aminomethanesulfonic acid, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhu, H, Gouaux, E.
Deposit date:2022-02-24
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-open state
To Be Published
7U2M
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BU of 7u2m by Molmil
A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-desenstized state
Descriptor: Glycine receptor subunit alphaZ1, aminomethanesulfonic acid, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhu, H, Gouaux, E.
Deposit date:2022-02-24
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-desenstized state
To Be Published
7U2O
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BU of 7u2o by Molmil
A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-Expanded-open state
Descriptor: Glycine receptor subunit alphaZ1, aminomethanesulfonic acid, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhu, H, Gouaux, E.
Deposit date:2022-02-24
Release date:2023-03-01
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-Expanded-open state
To Be Published

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