8U7H

Cryo-EM structure of LRRK2 bound to type I inhibitor GNE-7915

Summary for 8U7H

• Entry DOI: 10.2210/pdb8u7h/pdb
• EMDB information: 41982
• Descriptor: non-specific serine/threonine protein kinase, GUANOSINE-5'-DIPHOSPHATE, [4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoranyl-5-methoxy-phenyl]-morpholin-4-yl-methanone (3 entities in total)
• Functional Keywords: cryo-em, parkinson's disease, kinase, lrrk2, type i inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 137730.07

Authors

Zhu, H.,Sun, J. (deposition date: 2023-09-15, release date: 2024-01-31)

• Primary citation: Zhu, H.,Hixson, P.,Ma, W.,Sun, J.; Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM.; Cell Discov, 10:10-10, 2024; PubMed: 38263358; DOI: 10.1038/s41421-023-00639-8

Experimental method

ELECTRON MICROSCOPY (3.8 Å)