8U7H
Cryo-EM structure of LRRK2 bound to type I inhibitor GNE-7915
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 22 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGDGSFGSVYrAayegee............VAVK |
| Chain | Residue | Details |
| C | LEU1885-LYS1906 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKphNVLL |
| Chain | Residue | Details |
| C | ILE1990-LEU2002 |
| site_id | PS00626 |
| Number of Residues | 11 |
| Details | RCC1_2 Regulator of chromosome condensation (RCC1) signature 2. IGTGgGHILLL |
| Chain | Residue | Details |
| C | ILE2427-LEU2437 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| C | ASP1994 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00758, ECO:0000269|PubMed:18230735 |
| Chain | Residue | Details |
| C | GLY1341 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO9 |
| Chain | Residue | Details |
| C | LEU1885 | |
| C | ASP1887 | |
| C | ALA1904 | |
| C | GLU1948 | |
| C | ALA1950 | |
| C | ARG1957 | |
| C | LEU2001 | |
| C | ALA2016 | |
| C | ASP2017 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 |
| Chain | Residue | Details |
| C | GLY1888 | |
| C | VAL1893 | |
| C | SER1954 | |
| C | HIS1998 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8 |
| Chain | Residue | Details |
| C | GLY1891 | |
| C | MET1947 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| C | LYS1906 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00758 |
| Chain | Residue | Details |
| C | GLU2098 | |
| C | ASN2295 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:28202711 |
| Chain | Residue | Details |
| C | SER1444 |
