8U7H

Cryo-EM structure of LRRK2 bound to type I inhibitor GNE-7915

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0005525	molecular_function	GTP binding
C	0006468	biological_process	protein phosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	22
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGDGSFGSVYrAayegee............VAVK

Chain	Residue	Details
C	LEU1885-LYS1906

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKphNVLL

Chain	Residue	Details
C	ILE1990-LEU2002

---

site_id	PS00626
Number of Residues	11
Details	RCC1_2 Regulator of chromosome condensation (RCC1) signature 2. IGTGgGHILLL

Chain	Residue	Details
C	ILE2427-LEU2437

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	259
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	44
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	46
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00758","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18230735","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	26
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00758","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"28202711","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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