8U7H
Cryo-EM structure of LRRK2 bound to type I inhibitor GNE-7915
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | C | non-specific serine/threonine protein kinase | polymer | 1201 | 136843.5 | 1 | UniProt (Q17RV3) Pfam (PF08477) Pfam (PF16095) Pfam (PF00069) UniProt (by SIFTS) (Q5S007) In PDB | Homo sapiens (human) | |
| 2 | C | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 3 | C | [4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoranyl-5-methoxy-phenyl]-morpholin-4-yl-methanone | non-polymer | 443.4 | 1 | Chemie (A0T) |
Sequence modifications
C: 1327 - 2527 (UniProt: Q17RV3)
| PDB | External Database | Details |
|---|---|---|
| Arg 1732 | Met 1732 | conflict |
| Thr 2408 | Met 2408 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 136843.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 886.6 | |
| All* | Total formula weight | 137730.1 |
