Author results

5T2P
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HEPATITIS B VIRUS CORE PROTEIN Y132A MUTANT IN COMPLEX WITH SULFAMOYLBENZAMIDE (SBA_R01)
Descriptor:Core protein, 4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-~{N}-[3,4,5-tris(fluoranyl)phenyl]benzamide, ISOPROPYL ALCOHOL, ...
Authors:Zhou, Z., Xu, Z.H.
Deposit date:2016-08-24
Release date:2017-02-22
Method:X-RAY DIFFRACTION (1.693 Å)
Cite:Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms
Sci Rep, 7, 2017
5WRE
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HEPATITIS B VIRUS CORE PROTEIN Y132A MUTANT IN COMPLEX WITH HETEROARYLDIHYDROPYRIMIDINE (HAP_R01)
Descriptor:Core protein, (2S)-1-[[(4R)-4-(2-chloranyl-4-fluoranyl-phenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-4,4-bis(fluoranyl)pyrrolidine-2-carboxylic acid, ISOPROPYL ALCOHOL, ...
Authors:Zhou, Z., Xu, Z.H.
Deposit date:2016-12-01
Release date:2017-02-22
Method:X-RAY DIFFRACTION (1.946 Å)
Cite:Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms
Sci Rep, 7, 2017
5WTW
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HEPATITIS B VIRUS CORE PROTEIN Y132A MUTANT IN P 41 21 2 SPACE GROUP
Descriptor:Core protein, CHLORIDE ION
Authors:Zhou, Z., Xu, Z.H.
Deposit date:2016-12-15
Release date:2017-02-22
Method:X-RAY DIFFRACTION (2.623 Å)
Cite:Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms
Sci Rep, 7, 2017
2L5A
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STRUCTURAL BASIS FOR RECOGNITION OF CENTROMERE SPECIFIC HISTONE H3 VARIANT BY NONHISTONE SCM3
Descriptor:Histone H3-like centromeric protein CSE4, Protein SCM3, Histone H4
Authors:Zhou, Z., Feng, H., Zhou, B., Ghirlando, R., Hu, K., Zwolak, A., Jenkins, L., Xiao, H., Tjandra, N., Wu, C., Bai, Y.
Deposit date:2010-10-28
Release date:2011-03-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3.
Nature, 472, 2011
1SV2
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CRYSTAL STRUCTURE OF PEPTIDE DEFORMYLASE FROM LEPTOSPIRA INTERROGANS (LIPDF) AT PH7.5
Descriptor:Peptide deformylase, ZINC ION, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ...
Authors:Zhou, Z., Song, X., Li, Y., Gong, W.
Deposit date:2004-03-27
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift
J.Biol.Chem., 280, 2005
1SZZ
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CRYSTAL STRUCTURE OF PEPTIDE DEFORMYLASE FROM LEPTOSPIRA INTERROGANS COMPLEXED WITH INHIBITOR ACTINONIN
Descriptor:Peptide deformylase, ZINC ION, ACTINONIN
Authors:Zhou, Z., Song, X., Li, Y., Gong, W.
Deposit date:2004-04-06
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift
J.Biol.Chem., 280, 2005
1VEV
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CRYSTAL STRUCTURE OF PEPTIDE DEFORMYLASE FROM LEPTOSPIRA INTERROGANS (LIPDF) AT PH6.5
Descriptor:Peptide deformylase, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Zhou, Z., Song, X., Li, Y., Gong, W.
Deposit date:2004-04-06
Release date:2005-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift
J.Biol.Chem., 280, 2005
1VEY
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CRYSTAL STRUCTURE OF PEPTIDE DEFORMYLASE FROM LEPTOSPIRA INTERROGANS (LIPDF) AT PH7.0
Descriptor:Peptide deformylase, ZINC ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Zhou, Z., Song, X., Li, Y., Gong, W.
Deposit date:2004-04-06
Release date:2005-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift
J.Biol.Chem., 280, 2005
1VEZ
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CRYSTAL STRUCTURE OF PEPTIDE DEFORMYLASE FROM LEPTOSPIRA INTERROGANS(LIPDF) AT PH8.0
Descriptor:Peptide deformylase, ZINC ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Zhou, Z., Song, X., Li, Y., Gong, W.
Deposit date:2004-04-06
Release date:2005-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift
J.Biol.Chem., 280, 2005
1Y6H
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CRYSTAL STRUCTURE OF LIPDF
Descriptor:Peptide deformylase, ZINC ION, FORMIC ACID, ...
Authors:Zhou, Z., Song, X., Li, Y., Gong, W.
Deposit date:2004-12-06
Release date:2004-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Unique structural characteristics of peptide deformylase from pathogenic bacterium Leptospira interrogans
J.Mol.Biol., 339, 2004
2JSS
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NMR STRUCTURE OF CHAPERONE CHZ1 COMPLEXED WITH HISTONE H2A.Z-H2B
Descriptor:Chimera of Histone H2B.1 and Histone H2A.Z, Uncharacterized protein YER030W
Authors:Zhou, Z., Feng, H., Hansen, D.F., Kato, H., Luk, E., Freedberg, D.I., Kay, L.E., Wu, C., Bai, Y.
Deposit date:2007-07-11
Release date:2008-05-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.
Nat.Struct.Mol.Biol., 15, 2008
2L5V
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SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF HRPN13
Descriptor:Proteasomal ubiquitin receptor ADRM1
Authors:Zhou, Z., Hu, H.
Deposit date:2010-11-08
Release date:2011-11-09
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal domain of hRpn13
To be Published
2QJU
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CRYSTAL STRUCTURE OF AN NSS HOMOLOG WITH BOUND ANTIDEPRESSANT
Descriptor:Transporter, B-OCTYLGLUCOSIDE, SODIUM ION, ...
Authors:Zhou, Z., Karpowich, N.K., Wang, D.N., New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2007-07-09
Release date:2007-08-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
Science, 317, 2007
2RPI
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THE NMR STRUCTURE OF THE SUBMILLISECOND FOLDING INTERMEDIATE OF THE THERMUS THERMOPHILUS RIBONUCLEASE H
Descriptor:Ribonuclease H
Authors:Zhou, Z., Feng, H., Bai, Y.
Deposit date:2008-05-16
Release date:2009-03-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The high-resolution NMR structure of the early folding intermediate of the Thermus thermophilus ribonuclease H
J.Mol.Biol., 384, 2008
3GWU
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LEUCINE TRANSPORTER LEUT IN COMPLEX WITH SERTRALINE
Descriptor:Transporter, LEUCINE, SODIUM ION, ...
Authors:Zhou, Z., Zhen, J., Karpowich, N.K., Law, C.J., Reith, M.E.A., Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3GWV
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LEUCINE TRANSPORTER LEUT IN COMPLEX WITH R-FLUOXETINE
Descriptor:Transporter, LEUCINE, SODIUM ION, ...
Authors:Zhou, Z., Zhen, J., Karpowich, N.K., Law, C.J., Reith, M.E.A., Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3GWW
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LEUCINE TRANSPORTER LEUT IN COMPLEX WITH S-FLUOXETINE
Descriptor:Transporter, SODIUM ION, LEUCINE, ...
Authors:Zhou, Z., Zhen, J., Karpowich, N.K., Law, C.J., Reith, M.E.A., Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
5XS2
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CDK8-CYCC IN COMPLEX WITH COMPOUND 17:3-CHLORO-4-(4-PYRIDYL)-1H-PYRROLE-2-CARBOXAMIDE
Descriptor:Cyclin-dependent kinase 8, Cyclin-C, GLYCEROL, ...
Authors:Zhou, Z., Xu, Z.
Deposit date:2017-06-12
Release date:2017-08-09
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Discovery of potent and selective CDK8 inhibitors through FBDD approach
Bioorg. Med. Chem. Lett., 27, 2017
4RE1
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CRYSTAL STRUCTURE OF HUMAN TEAD1 AND DISULFIDE-ENGINEERED YAP
Descriptor:Transcriptional enhancer factor TEF-1, Yorkie homolog, CHLORIDE ION
Authors:Xu, Z., Zhou, Z.
Deposit date:2014-09-21
Release date:2014-11-19
Last modified:2015-09-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides.
Faseb J., 29, 2015
5XQX
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HUMAN CDK8-CYCC IN COMPLEX WITH COMPOUND 4: N-METHYL-4-(4-PYRIDYL)-1H-PYRROLE-2-CARBOXAMIDE
Descriptor:Cyclin-dependent kinase 8, Cyclin-C, GLYCEROL, ...
Authors:Zhou, Z., Xu, Z.H.
Deposit date:2017-06-07
Release date:2017-08-09
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of potent and selective CDK8 inhibitors through FBDD approach
Bioorg. Med. Chem. Lett., 27, 2017
5GMZ
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HEPATITIS B VIRUS CORE PROTEIN Y132A MUTANT IN COMPLEX WITH 4-METHYL HETEROARYLDIHYDROPYRIMIDINE
Descriptor:Core protein, ISOPROPYL ALCOHOL, (2S)-4,4-difluoro-1-[[(4S)-4-(4-fluorophenyl)-5-methoxycarbonyl-4-methyl-2-(1,3-thiazol-2-yl)-1H-pyrimidin-6-yl]methyl]pyrrolidine-2-carboxylic acid, ...
Authors:Xu, Z.H., Zhou, Z.
Deposit date:2016-07-18
Release date:2016-08-10
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors
J.Med.Chem., 59, 2016
1UJ1
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO)
Descriptor:3C-like proteinase
Authors:Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
Deposit date:2003-07-25
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
1UK2
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) AT PH8.0
Descriptor:3C-LIKE PROTEINASE
Authors:Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
Deposit date:2003-08-14
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
1UK3
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) AT PH7.6
Descriptor:3C-like proteinase
Authors:Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
Deposit date:2003-08-14
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
1UK4
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) COMPLEXED WITH AN INHIBITOR
Descriptor:3C-like proteinase, 5-mer peptide of inhibitor, CHLOROACETONE
Authors:Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
Deposit date:2003-08-14
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003