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3OXZ
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CRYSTAL STRUCTURE OF ABL KINASE DOMAIN BOUND WITH A DFG-OUT INHIBITOR AP24534
Descriptor:Tyrosine-protein kinase ABL1, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
Authors:Zhou, T., Huang, W.S., Wang, Y., Thomas, M., Keats, J., Xu, Q., Rivera, V., Shakespeare, W.C., Clackson, T., Dalgarno, D.C., Zhu, X.
Deposit date:2010-09-22
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance.
Chem.Biol.Drug Des., 77, 2011
3OY3
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CRYSTAL STRUCTURE OF ABL T315I MUTANT KINASE DOMAIN BOUND WITH A DFG-OUT INHIBITOR AP24589
Descriptor:Tyrosine-protein kinase ABL1, 5-[(5-{[4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(trifluoromethyl)phenyl]carbamoyl}-2-methylphenyl)ethynyl]-1-methyl-1H-imidazole-2-carboxamide
Authors:Zhou, T., Commodore, L., Huang, W.S., Wang, Y., Thomas, M., Keats, J., Xu, Q., Rivera, V., Shakespeare, W.C., Clackson, T., Dalgarno, D.C., Zhu, X.
Deposit date:2010-09-22
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance.
Chem.Biol.Drug Des., 77, 2011
4RX4
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CRYSTAL STRUCTURE OF VH1-46 GERMLINE-DERIVED CD4-BINDING SITE-DIRECTED ANTIBODY 8ANC134 IN COMPLEX WITH HIV-1 CLADE A Q842.D12 GP120
Descriptor:HIV-1 Clade A Q842.d12 gp120, 8ANC134 Heavy chain, 8ANC134 Light Chain, ...
Authors:Zhou, T., Acharya, P., Moquin, S., Kwong, P.D.
Deposit date:2014-12-08
Release date:2015-07-01
Last modified:2015-07-08
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell(Cambridge,Mass.), 161, 2015
4YDI
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CRYSTAL STRUCTURE OF BROAD AND POTENTLY NEUTRALIZING VRC01-CLASS ANTIBODY Z258-VRC27.01, ISOLATED FROM HUMAN DONOR Z258, IN COMPLEX WITH HIV-1 GP120 FROM CLADE A STRAIN Q23.17
Descriptor:Envelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY Z258-VRC27.01, LIGHT CHAIN OF ANTIBODY Z258-VRC27.01, ...
Authors:Zhou, T., Srivatsan, S., Kwong, P.D.
Deposit date:2015-02-22
Release date:2015-06-03
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (3.452 Å)
Cite:Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015
4YDJ
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY 44-VRC13.01 IN COMPLEX WITH HIV-1 CLADE AE STRAIN 93TH057 GP120
Descriptor:Envelope glycoprotein gp160,Envelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY 44-VRC13.01, LIGHT CHAIN OF ANTIBODY 44-VRC13.01, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2015-02-22
Release date:2015-06-03
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (2.308 Å)
Cite:Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015
4YDK
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY C38-VRC16.01 IN COMPLEX WITH HIV-1 CLADE AE STRAIN 93TH057 GP120
Descriptor:Envelope glycoprotein gp160,Envelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY C38-VRC16.01, LIGHT CHAIN OF ANTIBODY C38-VRC16.01, ...
Authors:Zhou, T., Moquin, S., Zheng, A., Kwong, P.D.
Deposit date:2015-02-22
Release date:2015-06-03
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (2.051 Å)
Cite:Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015
4YDL
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY C38-VRC18.02 IN COMPLEX WITH HIV-1 CLADE AE STRAIN 93TH057GP120
Descriptor:Envelope glycoprotein gp160,Envelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY C38-VRC18.02, LIGHT CHAIN OF ANTIBODY C38-VRC18.02, ...
Authors:Zhou, T., Srivatsan, S., Kwong, P.D.
Deposit date:2015-02-22
Release date:2015-06-03
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015
3KF4
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STRUCTURAL ANALYSIS OF DFG-IN AND DFG-OUT DUAL SRC-ABL INHIBITORS SHARING A COMMON VINYL PURINE TEMPLATE
Descriptor:Tyrosine-protein kinase ABL1, N-[4-(dimethylphosphoryl)phenyl]-9-[(E)-2-(5-methyl-1H-indazol-4-yl)ethenyl]-9H-purin-6-amine
Authors:Zhou, T.
Deposit date:2009-10-27
Release date:2009-12-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template.
Chem.Biol.Drug Des., 75, 2010
3KFA
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STRUCTURAL ANALYSIS OF DFG-IN AND DFG-OUT DUAL SRC-ABL INHIBITORS SHARING A COMMON VINYL PURINE TEMPLATE
Descriptor:Tyrosine-protein kinase ABL1, 3-{(E)-2-[6-(cyclopropylamino)-9H-purin-9-yl]ethenyl}-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide
Authors:Zhou, T.
Deposit date:2009-10-27
Release date:2009-12-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template.
Chem.Biol.Drug Des., 75, 2010
4LSP
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-CH31 IN COMPLEX WITH HIV-1 CLADE A/E GP120 93TH057
Descriptor:HIV-1 CLADE A/E STRAIN 93TH057 GP120, HEAVY CHAIN OF ANTIBODY VRC-CH31, LIGHT CHAIN OF ANTIBODY VRC-CH31, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-09-04
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSQ
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-CH31 IN COMPLEX WITH HIV-1 CLADE A/E GP120 93TH057 WITH LOOP D AND LOOP V5 FROM CLADE A STRAIN 3415_V1_C1
Descriptor:ENVELOPE GLYCOPROTEIN GP120 WITH LOOP D AND V5 FROM STRAIN 3415_V1_C1, HEAVY CHAIN OF ANTIBODY VRC-CH31, LIGHT CHAIN OF ANTIBODY VRC-CH31 WITH N70D MUTATION, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSR
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-CH31 IN COMPLEX WITH HIV-1 CLADE A/E STRAN 93TH057 GP120 WITH LOOP D AND LOOP V5 FROM CLADE A STRAIN KER_2018_11
Descriptor:ENVELOPE GLYCOPROTEIN GP120 WITH LOOP D AND V5 FROM STRAIN ker_2018_11, HEAVY CHAIN OF ANTIBODY VRC-CH31, LIGHT CHAIN OF ANTIBODY VRC-CH31 (N70D MUTATION), ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSS
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC01 IN COMPLEX WITH HIV-1 CLADE A STRAIN KER_2018_11 GP120
Descriptor:envelope glycoprotein GP120, HEAVY CHAIN OF ANTIBODY VRC01, LIGHT CHAIN OF ANTIBODY VRC01 with N72T mutation, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LST
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC01 IN COMPLEX WITH HIV-1 CLADE C STRAIN ZM176.66 GP120
Descriptor:ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, HEAVY CHAIN OF ANTIBODY VRC01, LIGHT CHAIN OF ANTIBODY VRC01, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSU
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-PG20 IN COMPLEX WITH HIV-1 CLADE A/E 93TH057 GP120
Descriptor:HIV-1 CLADE A/E STRAIN 93TH057 GP120, HEAVY CHAIN OF ANTIBODY VRC-PG20, LIGHT CHAIN OF ANTIBODY VRC-PG20, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSV
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY 3BNC117 IN COMPLEX WITH HIV-1 CLADE C C1086 GP120
Descriptor:envelope glycoprotein GP120, HEAVY CHAIN OF ANTIBODY 3BNC117, LIGHT CHAIN OF ANTIBODY 3BNC117, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
1F48
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CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE
Descriptor:ARSENITE-TRANSLOCATING ATPASE, ANTIMONY (III) ION, MAGNESIUM ION, ...
Authors:Zhou, T., Radaev, S., Rosen, B.P., Gatti, D.L.
Deposit date:2000-06-07
Release date:2000-09-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump.
EMBO J., 19, 2000
1FWK
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CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH ADP
Descriptor:HOMOSERINE KINASE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Zhou, T., Daugherty, M., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2000-09-22
Release date:2000-12-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.
Structure Fold.Des., 8, 2000
1FWL
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CRYSTAL STRUCTURE OF HOMOSERINE KINASE
Descriptor:HOMOSERINE KINASE
Authors:Zhou, T., Daugherty, M., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2000-09-22
Release date:2000-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.
Structure Fold.Des., 8, 2000
1IHU
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CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE IN COMPLEX WITH MG-ADP-ALF3
Descriptor:ARSENICAL PUMP-DRIVING ATPASE, MAGNESIUM ION, CADMIUM ION, ...
Authors:Zhou, T., Radaev, S., Rosen, B.P., Gatti, D.L.
Deposit date:2001-04-20
Release date:2001-09-12
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation.
J.Biol.Chem., 276, 2001
1II0
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CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE
Descriptor:ARSENICAL PUMP-DRIVING ATPASE, CADMIUM ION, CHLORIDE ION, ...
Authors:Zhou, T., Radaev, S., Rosen, B.P., Gatti, D.L.
Deposit date:2001-04-20
Release date:2001-09-12
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation.
J.Biol.Chem., 276, 2001
1II9
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CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE IN COMPLEX WITH AMP-PNP
Descriptor:ARSENICAL PUMP-DRIVING ATPASE, MAGNESIUM ION, CADMIUM ION, ...
Authors:Zhou, T., Radaev, S., Gatti, D.L., Rosen, B.P.
Deposit date:2001-04-21
Release date:2001-09-12
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation.
J.Biol.Chem., 276, 2001
1KQN
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CRYSTAL STRUCTURE OF NMN/NAMN ADENYLYLTRANSFERASE COMPLEXED WITH NAD
Descriptor:NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, XENON
Authors:Zhou, T., Kurnasov, O., Tomchick, D.R., Binns, D.D., Grishin, N.V., Marquez, V.E., Osterman, A.L., Zhang, H.
Deposit date:2002-01-07
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Human Nicotinamide/Nicotonic Acid Mononucleotide Adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
J.Biol.Chem., 277, 2003
1KQO
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CRYSTAL STRUCTURE OF NMN/NAMN ADENYLYLTRANSFERASE COMPLEXED WITH DEAMIDO-NAD
Descriptor:NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE, NICOTINIC ACID ADENINE DINUCLEOTIDE
Authors:Zhou, T., Kurnasov, O., Tomchick, D.R., Binns, D.D., Grishin, N.V., Marquez, V.E., Osterman, A.L., Zhang, H.
Deposit date:2002-01-07
Release date:2003-01-07
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Hhuman of Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
J.Biol.Chem., 277, 2002
1KR2
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CRYSTAL STRUCTURE OF HUMAN NMN/NAMN ADENYLYL TRANSFERASE COMPLEXED WITH TIAZOFURIN ADENINE DINUCLEOTIDE (TAD)
Descriptor:NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE, BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE
Authors:Zhou, T., Kurnasov, O., Tomchick, D.R., Binns, D.D., Grishin, N.V., Marquez, V.E., Osterman, A.L., Zhang, H.
Deposit date:2002-01-08
Release date:2003-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of Hhuman of Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
J.Biol.Chem., 277, 2002